Results 61 to 70 of about 5,296,721 (231)

Expanding Genetic Code to Generate Human Brain Organoids with Both Vasculature and Microglia‐Like Cells

Advanced Science, EarlyView.
Using genetic code expansion, we engineered vascularized human cerebral organoids (vhCOs) with microglia‐like cells and blood‐brain barrier features. vhCOs recapitulate neurovascular interactions, regional identities, and neuronal subtypes resembling the fetal brain.
Haishuang Lin, Yaqing Wang, Hu Du, Yuxin Qin, Haoyu Zhang, Peng Wang, Lin Wei, Jianhua Qin   +7 more
wiley   +1 more source

The structural and functional integrity of peripheral nerves depends on the glial-derived signal desert hedgehog [PDF]

, 2006
We show that desert hedgehog ( dhh), a signaling molecule expressed by Schwann cells, is essential for the structural and functional integrity of the peripheral nerve.
Umehara, F, Meier, C, Turmaine, M, Jessen, KR, Sharghi-Namini, S, Sahni, V, Mirsky, R   +6 more
core  

Macrophage Dab1 Links Early Hypoxia to Adaptive Angiogenesis to Drive Peripheral Nerve Repair

Advanced Science, EarlyView.
Schematic diagram illustrating the Dab1‐linked hypoxia signaling pathway that accelerates angiogenesis and consequent nerve regeneration. Following PNI, a hypoxic microenvironment develops. Hypoxia induces macrophage Dab1 phosphorylation, resulting in NHE‐1 upregulation, HIF‐1α stabilization, and VEGF‐A expression. This cascade promotes angiogenesis in
Xiongyao Zhou, Fan Zhang, Jiangbo Wang, Huiyuan Wang, Zongqiang Wang, Qianqian Wang, Chuikai Meng, Jialu Sun, Han Wang, Weiye Li, Ziyi Zhao, Le Qi, Xiaosong Gu, Shusen Cui, Rangjuan Cao   +14 more
wiley   +1 more source

Precision Nanomedicine for Traumatic Neural Injury: Functional Paradigms and Translational Frameworks

Advanced Science, EarlyView.
This review presents a pathology‐driven framework unifying nanomedicine across TBI, SCI, and PNI. Epidemiological evidence and comparative single‐cell transcriptomic reanalysis define shared pathological modules, injury‐specific effectors, and therapeutic bottlenecks. Six functional paradigms connect nanomaterial structure and biological fate to injury‐
Mouyuan Sun, Shuangyang Li, Zhixu He, Jingyi Xie, Yaxian Luo, Xuankai Fan, Jingyu Zhang, Luying Qin, Lianjie Peng, Tao Qiu, Tian Zhang, Huiming Wang, Mengfei Yu   +12 more
wiley   +1 more source

Macrophage-Induced Blood Vessels Guide Schwann Cell-Mediated Regeneration of Peripheral Nerves [PDF]

, 2015
The peripheral nervous system has remarkable regenerative capacities in that it can repair a fully cut nerve. This requires Schwann cells to migrate collectively to guide regrowing axons across a ‘bridge’ of new tissue, which forms to reconnect a severed
Mackenzie, FE, Lloyd, AC, Hoving, JJ, Garcia Calavia, N, Quereda, Victor, Cattin, A-L, McLaughlin, M, Cattin, AL, Napoli, I, Enver, T, Quereda, V, Parrinello, S, Napoli, Ilaria, Ruhrberg, C, Guo, Yanping, Jamecna, D, Burden, JJ, Hoving, JJA, Rosenberg, LH, Ruhrberg, Christiana, Parrinello, Simona, Jamecna, Denisa, Guo, Y, Van Emmenis, L, McLaughlin, Maeve, Enver, Tariq, Calavia, NG, Cattin, Anne-Laure, Van Emmenis, Lucie, Burden, Jemima J., Rosenberg, Laura H., Mackenzie, Francesca E., Garcia Calavia, Noelia, Hoving, Julian J.A., Lloyd, Alison C.   +34 more
core   +1 more source

Atlas‐Guided CD55‐Enriched Neutrophil Extracellular Vesicles for Complement–Macrophage Modulation in Diabetic Wounds

Advanced Science, EarlyView.
ABSTRACT Diabetic wounds are characterized by persistent inflammation and impaired immune resolution, yet the therapeutic translation of single‐cell atlases into rational immunomodulatory strategies remains limited. Here, integration of diabetic‐wound single‐cell transcriptomic datasets identifies a neutrophil subpopulation enriched in cluster of ...
Tairong Cui, Jieying Li, Jibing He, Jia Wang, Yun Qian, Yilin Jin, Liuqing Yang, Zaijin Tao, Ziyun Li, Zhengsheng Chen, Wenjing Wang, Xin Ma, Jinglei Wu   +12 more
wiley   +1 more source

Schwann Cell Precursors from Human Pluripotent Stem Cells as a Potential Therapeutic Target for Myelin Repair

Stem Cell Reports, 2017
Schwann cells play a crucial role in successful nerve repair and regeneration by supporting both axonal growth and myelination. However, the sources of human Schwann cells are limited both for studies of Schwann cell development and biology and for the ...
Han-Seop Kim, Jungwoon Lee, Da Yong Lee, Young-Dae Kim, Jae Yun Kim, Hyung Jin Lim, Sungmin Lim, Yee Sook Cho   +7 more
doaj   +1 more source

A transgenic mouse with PMP-22 directed GFP expression - a model for schwann cell behaviour [PDF]

, 2001
In the peripheral nervous system the myelin sheath is produced by the spiral wrappings of the Schwann cell (SC) membrane around the axon. This provides insulation and increases the velocity of impulse propagation. The structure of myelin is maintained by
Wright, Angela Morag
core  

Aspects of cell growth control illustrated by the Schwann cell

, 2012
The control of cell biogenesis remains poorly understood, despite being critical for the development and maintenance of all organisms. Studies in vitro and in vivo using the Schwann cell, the glial cell of the peripheral nervous system, have provided ...
Alison C. Lloyd, Sinead A. Roberts
core   +1 more source

Single‐Nucleus RNA Sequencing Identifies CREM as a Brake on Myofiber Hypertrophy in Chickens

Advanced Science, EarlyView.
Single‐nucleus RNA sequencing on 91 144 nuclei from postnatal chicken pectoralis major between fast‐growing broilers (FG) and slow‐growing layers (SG) identifies the transcriptional factor CREM as a novel brake of myofiber hypertrophy. Mechanistically, functional validation experiments confirm that CREM activates the promoter of JUN and CREM deletion ...
Shuang Gu, Xiyu Zhao, Zheyi Jiang, Chaoliang Wen, Chaoyi Wang, Qiulian Wang, Qiang Huang, Fangren Lan, Shenghui Wu, Junying Li, Congjiao Sun, Huadong Yin, Ning Yang   +12 more
wiley   +1 more source