Results 11 to 20 of about 59,666 (198)

SOX10 transactivates S100B to suppress Schwann cell proliferation and to promote myelination. [PDF]

PLoS ONE, 2014
Schwann cells are an important cell source for regenerative therapy for neural disorders. We investigated the role of the transcription factor sex determining region Y (SRY)-box 10 (SOX10) in the proliferation and myelination of Schwann cells.
Sayaka Fujiwara, Shinya Hoshikawa, Takaaki Ueno, Makoto Hirata, Taku Saito, Toshiyuki Ikeda, Hiroshi Kawaguchi, Kozo Nakamura, Sakae Tanaka, Toru Ogata   +9 more
doaj   +1 more source

SPIONs mediated magnetic actuation promotes nerve regeneration by inducing and maintaining repair-supportive phenotypes in Schwann cells

Journal of Nanobiotechnology, 2022
Background Schwann cells, the glial cells in the peripheral nervous system, are highly plastic. In response to nerve injury, Schwann cells are reprogrammed to a series of specialized repair-promoting phenotypes, known as repair Schwann cells, which play ...
Ting Liu, Yang Wang, Laijin Lu, Yi Liu
doaj   +1 more source

Contribution of Schwann Cells to Remyelination in a Naturally Occurring Canine Model of CNS Neuroinflammation. [PDF]

PLoS ONE, 2015
Gliogenesis under pathophysiological conditions is of particular clinical relevance since it may provide evidence for regeneration promoting cells recruitable for therapeutic purposes.
Kristel Kegler, Ingo Spitzbarth, Ilka Imbschweiler, Konstantin Wewetzer, Wolfgang Baumgärtner, Frauke Seehusen   +5 more
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Schwann cells regulate tumor cells and cancer-associated fibroblasts in the pancreatic ductal adenocarcinoma microenvironment

Nature Communications, 2023
Neuropathy is a feature more frequently observed in pancreatic ductal adenocarcinoma (PDAC) than other tumors. Schwann cells, the most prevalent cell type in peripheral nerves, migrate toward tumor cells and associate with poor prognosis in PDAC.
Meilin Xue, Youwei Zhu, Yongsheng Jiang, Lijie Han, Minmin Shi, Rui Su, Liwen Wang, Cheng Xiong, Chaofu Wang, Ting Wang, Shijie Deng, Dong Wu, Yizhi Cao, Lei Dong, Fan Bai, Shulin Zhao, Xiaxing Deng, Chenghong Peng, Hongwei Li, Jianjun Chen, Baiyong Shen, Lingxi Jiang, Hao Chen   +22 more
doaj   +1 more source

Long non-coding RNA NONMMUG014387 promotes Schwann cell proliferation after peripheral nerve injury

Neural Regeneration Research, 2017
Schwann cells play a critical role in peripheral nerve regeneration through dedifferentiation and proliferation. In a previous study, we performed microarray analysis of the sciatic nerve after injury.
Bin Pan, Zhong-ju Shi, Jia-yin Yan, Jia-he Li, Shi-qing Feng   +4 more
doaj   +1 more source

Influence of cold-stimulated adipocyte supernatant on the expression of adhesion-related molecules in Schwann cell line

Biochemistry and Biophysics Reports, 2023
Bell's palsy is the most common form of facial nerve palsy. This study aimed to explore the pathogenesis of Bell's palsy by investigating the effect of cold-stimulated adipocyte supernatant on adhesion molecule expression in Schwann cell line.
Tiefeng Zhang, Yaxin Gan, Yulan Bai, Weijiang Hao, Ziqi Zeng, Feng Wu, Xianqi Li   +6 more
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Heme Oxygenase 1 in Schwann Cells Regulates Peripheral Nerve Degeneration Against Oxidative Stress

ASN Neuro, 2019
During Wallerian degeneration, Schwann cells lose their characteristic of myelinating axons and shift into the state of developmental promyelinating cells.
Muwoong Kim, Hyosun Kim, Dogyeong Kim, Dokyoung Kim, Youngbuhm Huh, Chan Park, Hyung-Joo Chung, Junyang Jung, Na Young Jeong   +8 more
doaj   +1 more source

Analysis of Schwann Cell Migration and Axon Regeneration Following Nerve Injury in the Sciatic Nerve Bridge

Frontiers in Molecular Neuroscience, 2019
While it is proposed that interaction between Schwann cells and axons is key for successful nerve regeneration, the behavior of Schwann cells migrating into a nerve gap following a transection injury and how migrating Schwann cells interact with ...
Bing Chen, Quan Chen, David B. Parkinson, Xin-peng Dun   +3 more
doaj   +1 more source

Ablation of Dicer from murine Schwann cells increases their proliferation while blocking myelination. [PDF]

PLoS ONE, 2010
The myelin sheaths that surround the thick axons of the peripheral nervous system are produced by the highly specialized Schwann cells. Differentiation of Schwann cells and myelination occur in discrete steps.
Juliane Bremer, Tracy O'Connor, Cinzia Tiberi, Hubert Rehrauer, Joachim Weis, Adriano Aguzzi   +5 more
doaj   +1 more source

Mouse Schwann cells activate MHC class I and II restricted T-cell responses, but require external peptide processing for MHC class II presentation

Neurobiology of Disease, 2010
Schwann cells are the myelinating glia cells of the peripheral nervous system (PNS). In inflammatory neuropathies like the Guillain-Barré syndrome (GBS) Schwann cells become target of an autoimmune response, but may also modulate local inflammation. Here,
Gerd Meyer zu Hörste, Holger Heidenreich, Anne K. Mausberg, Helmar C. Lehmann, Anneloor L.M.A. ten Asbroek, José T. Saavedra, Frank Baas, Hans-Peter Hartung, Heinz Wiendl, Bernd C. Kieseier   +9 more
doaj   +1 more source