Results 31 to 40 of about 68,795 (281)
Heme Oxygenase 1 in Schwann Cells Regulates Peripheral Nerve Degeneration Against Oxidative Stress
ASN Neuro, 2019 During Wallerian degeneration, Schwann cells lose their characteristic of myelinating axons and shift into the state of developmental promyelinating cells.
Muwoong Kim +8 more
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Frontiers in Molecular Neuroscience, 2019 While it is proposed that interaction between Schwann cells and axons is key for successful nerve regeneration, the behavior of Schwann cells migrating into a nerve gap following a transection injury and how migrating Schwann cells interact with ...
Bing Chen +3 more
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Mice lacking protease nexin-1 show delayed structural and functional recovery after sciatic nerve crush [PDF]
, 2007 Multiple molecular mechanisms influence nerve regeneration. Because serine proteases were shown to affect peripheral nerve regeneration, we performed nerve crush experiments to study synapse reinnervation in adult mice lacking the serpin protease nexin-1
Atanasoski, Suzana +7 more
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Frontiers in Cellular Neuroscience, 2021 Embryonic Dissociated Dorsal Root Ganglia (DRG) cultures are often used to investigate the role of novel molecular pathways or drugs in Schwann cell development and myelination.
Venkat Krishnan Sundaram +7 more
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TNFα promotes oral cancer growth, pain, and Schwann cell activation
Scientific Reports, 2021 Oral cancer is very painful and impairs a patient’s ability to eat, talk, and drink. Mediators secreted from oral cancer can excite and sensitize sensory neurons inducing pain.
Elizabeth Salvo +6 more
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Lithium promotes proliferation and suppresses migration of Schwann cells
Neural Regeneration Research, 2020 Schwann cell proliferation, migration and remyelination of regenerating axons contribute to regeneration after peripheral nervous system injury. Lithium promotes remyelination by Schwann cells and improves peripheral nerve regeneration.
Xiao-Kun Gu +3 more
doaj +1 more source
Inhibition of Schwann Cell Pyroptosis Promotes Nerve Regeneration in Peripheral Nerve Injury in Rats
Mediators of Inflammation, 2023 Background. Peripheral nerve injury (PNI) is one of the most debilitating injuries, but therapies for PNI are still far from satisfactory. Pyroptosis, a recently identified form of cell death, has been demonstrated to participate in different diseases ...
Jiayi Wang +9 more
doaj +1 more source
Autophagy is involved in the reduction of myelinating Schwann cell cytoplasm during myelin maturation of the peripheral nerve. [PDF]
PLoS ONE, 2015 Peripheral nerve myelination involves dynamic changes in Schwann cell morphology and membrane structure. Recent studies have demonstrated that autophagy regulates organelle biogenesis and plasma membrane dynamics.
So Young Jang +7 more
doaj +1 more source
, 2012 The radical response of peripheral nerves to injury (Wallerian degeneration) is the cornerstone of nerve repair. We show that activation of the transcription factor c-Jun in Schwann cells is a global regulator of Wallerian degeneration.
Jenkins, Billy +35 more
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The septin cytoskeleton is associated with distinct myelin structures of the central and peripheral nervous system [PDF]
, 2008 Rapid conduction of nerve impulses in the nervous system of higher vertebrates is made possible by ensheathment of nerve fibers by the specialized plasma membrane structure myelin. Consequently, failure of myelination or damage to the myelin sheath leads
Buser, Andres
core +1 more source