Results 191 to 200 of about 51,731 (281)

Intricate Regulation of Sphingolipid Biosynthesis: An In‐Depth Look Into ORMDL‐Mediated Regulation of Serine Palmitoyltransferase

open access: yesBioEssays, Volume 47, Issue 9, September 2025.
Multiple enzymes play a crucial role in regulating the biosynthesis of de novo sphingolipids. This regulation starts with the rate‐limiting enzyme, serine palmitoyltransferase (SPT), which catalyzes the first step of the pathway. Disruptions in this regulatory process can lead to serious diseases.
Usha Mahawar, Binks Wattenberg
wiley   +1 more source

Heteromultimeric Delayed-Rectifier K+Channels in Schwann Cells: Developmental Expression and Role in Cell Proliferation [PDF]

open access: hybrid, 1998
Alex Sobko   +6 more
openalex   +1 more source

Oligodendrogenesis in Evolution, Development and Adulthood

open access: yesGlia, Volume 73, Issue 9, Page 1770-1783, September 2025.
Main Points Oligodendrocytes and myelin took shape in jawed vertebrates During development, OPCs are originated from NSCs and then undergo differentiation into mature oligodendrocytes that supply myelin. OPCs persist in the adult CNS and continue to produce oligodendrocytes and myelin.
Hao Hu   +3 more
wiley   +1 more source

Polarization of myelinating Schwann cell surface membranes: role of microtubules and the trans-Golgi network [PDF]

open access: hybrid, 1995
BD Trapp   +5 more
openalex   +1 more source

Chondrodystrophic Dogs as a Preclinical Large Animal Model of Discogenic Back Pain

open access: yesJOR SPINE, Volume 8, Issue 3, September 2025.
This study aims to validate an underutilized canine preclinical model of discogenic back pain model by deep phenotyping several structural and pain associated outcomes with novel findings in the areas of RNA sequencing and whole patch clamp of canine dorsal root ganglion neurons.
Mary K. Heimann   +18 more
wiley   +1 more source

A Conceptual Review of Naturally Occurring Toxins and Venoms as Peptide Blockers to Combat Chronic Low Back Pain

open access: yesJOR SPINE, Volume 8, Issue 3, September 2025.
This review explores the therapeutic potential of naturally occurring venom‐derived peptides, particularly from reptiles and insects, as novel calcium channel blockers for managing chronic low back pain caused by intervertebral disc degeneration.
James Melrose   +4 more
wiley   +1 more source

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