Results 171 to 180 of about 7,401 (261)

Reversing Macrophage Immunometabolic Dysfunction in Prolonged Infections Via a Glutaminolysis‐Fueled Restoration‐Based Hierarchically Selective Therapeutic System

Advanced Science, EarlyView.
A hierarchically selective immunotherapeutic nanoplatform, mGls@HEV‐MTP, selectively restores macrophage immunocompetence through GLS1‐mediated restoration of glutaminolysis‐fueled anaplerosis. Concurrently, it renders Staphylococcus aureus (S. aureus) more readily recognizable to the metabolically reprogrammed macrophages, thereby facilitating ...
Weinan Yang, Zihao An, Honglu Cai, Congsun Li, Jiaxuan Zou, Wushi Cui, Wentao Chen, Tao Zhang, Shicheng Wang, Zizhan Su, Jian Xiao, Tao Sun, Bin Hu, Min Cheng, Zhongru Gou, Jianbin Xu, An Liu, Haobo Wu   +17 more
wiley   +1 more source

When academic leaders disconnect from social media in Finland: Situational rationality, silent resistance. [PDF]

Public Underst Sci
Ripatti-Torniainen L, Talvitie-Lamberg K.   +1 more
europepmc   +1 more source

TECTB Variants Reveal Tectorial Membrane Vulnerability in Dominant Non‐Syndromic Hearing Loss

Advanced Science, EarlyView.
TECTB is a non‐collagenous protein of the tectorial membrane – an extracellular matrix of the cochlea. This study identifies dominant missense variants in TECTB linked to human hereditary deafness in two unrelated families. Genetically engineered mice homozygous for one of the variants are profoundly deaf, whereas heterozygous mice have normal hearing ...
Evan B. Hale, Barbara Vona, Richard J. Goodyear, Richard T. Osgood, Jun Shen, Sami S. Amr, Karen Mojica, Michaela A. H. Hofrichter, Jörg Schröder, Sophie Flandin, Paul Gratias, Ricardo Vera‐Monroy, Katherine Callahan, Kerry L. Gudlewski, Rolen Quadros, Masato Ohtsuka, JoAnn McGee, Edward J. Walsh, Cynthia C. Morton, Thomas Haaf, Channabasavaiah Gurumurthy, James E. Saunders, Guy P. Richardson, Artur A. Indzhykulian   +23 more
wiley   +1 more source

Collaboration scripts in computer-supported collaborative learning: a systematic review from 2011 to 2024. [PDF]

Front Psychol
Jiao F, Bian J, Zhang R, Zhou T.
europepmc   +1 more source

Highly‐Time‐Resolved Measurements of Tryptophan's Distribution and Homeostatic Regulation in Live, Intact Animals

Advanced Science, EarlyView.
Using a novel, aptamer‐based biosensor, here we have performed 20‐s‐resolved, in situ measurements of plasma‐free tryptophan in the jugular veins of live rats (blue). This unprecedented time‐resolution provides insights into the regulation of tryptophan metabolism in live, intact animals.
Yuyang Wu, Chelsea N. Brown, Zeki Duman, Rose Mery Bakestani, Carl M. Kirkpatrick, Joao Hespanha, Tod Kippin, Kevin W. Plaxco   +7 more
wiley   +1 more source

Reframing Harm and Evidence: Advocacy Coalitions and the Transformation of Finnish Alcohol Policy. [PDF]

Nordisk Alkohol Nark
Westermarck J, Katainen A, Hellman M, Warpenius K.   +3 more
europepmc   +1 more source

Pressure‐Tuned Superconducting Dome and Persistent Charge‐Density‐Wave Order in NdSeTe2

Advanced Science, EarlyView.
NdSeTe2 exhibits an unusual pressure‐tuned phase diagram in which charge‐density‐wave order does not disappear at optimal superconductivity. Instead, Raman spectroscopy reveals a transformation from long‐range to short‐range correlations that remain invisible to resistivity and persist across the entire superconducting dome.
Shuyang Wang, Chao An, Jiaqi Chen, Lili Zhang, Yonghui Zhou, Xuliang Chen, Zhaorong Yang   +6 more
wiley   +1 more source

Replication and replicability as epistemic opportunity for the humanities: reflections on a Rembrandt attribution case study. [PDF]

Humanit Soc Sci Commun
Rulkens CCS, Peels R, Stols-Witlox M, Bouter L.   +3 more
europepmc   +1 more source

Supramolecular Zinc–Polyphenol Coordination Assemblies Mitigate Colonic Inflammation by Regulating Mucosal Barrier and Microbiome

Advanced Science, EarlyView.
A carrier‐free zinc‐coordinated polyphenol nanoplatform (ZnCA NPs) is designed as an “all‐in‐one” therapeutic strategy for intestinal inflammation. The ZnCA NPs exhibit enhanced colonic accumulation and broad‐spectrum reactive oxygen and nitrogen species scavenging.
Qiwen Xie, Mai Ye, Xuexia Liu, Jing Wang, Ying Chen, Lu Tan, Jinheng Fu, Xiaochang Huang   +7 more
wiley   +1 more source