Results 201 to 210 of about 7,401 (261)

Restores Aβ Clearance by Overcoming PCSK9–LRP1 Dysregulation and TRIB3‐Mediated Autophagy Blockade in Alzheimer's Disease

Advanced Science, EarlyView.
PCSK9 upregulation in cerebrovascular endothelial cells and microglia destabilizes the Aβ transporter LRP1, while TRIB3‐associated autophagy blockade further limits intracellular Aβ degradation. A RAP‐modified tea‐polyphenol nanoparticle co‐delivers siPCSK9 and siTRIB3 to restore LRP1‐mediated Aβ efflux and autophagy‐dependent degradation, reducing Aβ ...
Jie Miao, Jing Wang, Yankun Li, Haipei Zhang, Yanli Zhang, Qingnian Li, Bo Xiao, Wenhu Zhou, Junhong Guo   +8 more
wiley   +1 more source

Evaluating Socratic inquiry, reflection and argumentation as strategies for critical thinking. [PDF]

Curationis
Malape GT, Makhene A, Mutava E.
europepmc   +1 more source

Collective moderation of hate, toxicity, and extremity in online discussions. [PDF]

PNAS Nexus
Lasser J, Herderich A, Garland J, Aroyehun ST, Garcia D, Galesic M.   +5 more
europepmc   +1 more source

Critical Thinking and Epistemic Sophistication in Science Education. [PDF]

J Intell
Tamayo Alzate OE.
europepmc   +1 more source

The research program subjective theories: A methodological concept for a wide range of applications. [PDF]

GMS J Med Educ
Gadewoltz PN.
europepmc   +1 more source

Trust and doubt coexist: an empirical study on the acceptance mechanism of transgenic technology among Chinese youth. [PDF]

GM Crops Food
Qu C, Pang Y, Wu Z.
europepmc   +1 more source

Capturing Argument in Agent-Based Models. [PDF]

Topoi (Dordr)
Assaad L, Fuchs R, Phillips K, Schöppl K, Hahn U.   +4 more
europepmc   +1 more source

Network psychometrics in practice: A practical framework for designing empirical studies that utilize a psychological network approach. [PDF]

Behav Res Methods
Chambon M, Dalege J, Elberse JE, van Harreveld F.   +3 more
europepmc   +1 more source