Results 41 to 50 of about 9,382,254 (295)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

SPECIFICS OF SCIENTIFIC RESEARCH WORK IN HUMANITIES

Pravo, 2008
Methodology of scientific research work represents a sort of treusary of experiences till date of scientists from various fields. The refore, many topics remained outside the scope of this paper. On the other hand, the basic issues of methodology (method
Lynne Montgomery, Zdravko Jež, Snežana Prelević   +2 more
doaj  

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Group mentoring of youth scientists to enhance the students’ research literacy

Journal of Community Service and Empowerment, 2023
The Youth Scientific Group (YSG) is an extracurricular activity that has a positive impact on students. Unfortunately, the presence of YSG in various schools, including SMAN 1 Tumpang, is still not optimal. In this high school located in Malang Regency,
Ahmad Fauzi, Lud Waluyo, Diani Fatmawati, Siti Zubaidah, Sitaresmi Weka Sukrisno, Nafisa Nur Azizah   +5 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Research on Scientific Data Security Behavior Based on Scientific Research Process

Zhishi guanli luntan, 2019
[Purpose/significance] This paper defines the concept of scientific data security behavior, and combines different stages of research activities to analyze how to ensure the safety of scientific data in the ...
Yang Yan, Ruan Jianhai
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Undergraduate Research Fellows to Present Scientific Research at Annual SURF Conference on July 28 [PDF]

, 2017
Culminating a 10-week fellowship, 19 RWU students will present diverse research on the impact of climate change on the environment and biomedical ...
Public Affairs, Roger Williams University
core   +1 more source

Good practices, innovation or scientific research in education? A conceptual reflection [PDF]

, 2020
In this work a conceptual delimitation of "good teaching practices", "educational innovation" and "educational research" is proposed, based on both the experimental design and the quality of the evidence provided by these ...
Hernández Fernández, Antonio
core