Results 41 to 50 of about 4,856,383 (280)

Clinical research and sampling in the scientific: Research work [PDF]

Sestrinska reč, 2015
The survey is used to verify existing knowledge, to extend or discover a previously unknown knowledge, with the aim to come to the knowledge in the most efficient manner.
Peličić Damir, Radunović Danilo, Dobrović Dragica, Bokan Darijo   +3 more
doaj  

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

SPECIFICS OF SCIENTIFIC RESEARCH WORK IN HUMANITIES

Pravo, 2008
Methodology of scientific research work represents a sort of treusary of experiences till date of scientists from various fields. The refore, many topics remained outside the scope of this paper. On the other hand, the basic issues of methodology (method
Lynne Montgomery, Zdravko Jež, Snežana Prelević   +2 more
doaj  

Group mentoring of youth scientists to enhance the students’ research literacy

Journal of Community Service and Empowerment, 2023
The Youth Scientific Group (YSG) is an extracurricular activity that has a positive impact on students. Unfortunately, the presence of YSG in various schools, including SMAN 1 Tumpang, is still not optimal. In this high school located in Malang Regency,
Ahmad Fauzi, Lud Waluyo, Diani Fatmawati, Siti Zubaidah, Sitaresmi Weka Sukrisno, Nafisa Nur Azizah   +5 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

The Epistemic Integrity of Scientific Research [PDF]

Science and Engineering Ethics, 2012
We live in a world in which scientific expertise and its epistemic authority become more important. On the other hand, the financial interests in research, which could potentially corrupt science, are increasing. Due to these two tendencies, a concern for the integrity of scientific research becomes increasingly vital.
De Winter, Jan, Kosolosky, Laszlo
openaire   +3 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Phenocam - Red Green Blue (RGB) Composite Image Mean Values from Abisko Scientific Research Station

Phenocamera RGB composite averaged daily from quality-filtered photos from 10 a.m. to 2 p.m. Abisko Scientific Research Station (2024). Phenocam - Red Green Blue (RGB) Composite Image Mean Values from Abisko Scientific Research Station, 2023-04-01–2023 ...
Abisko Scientific Research Station
core   +2 more sources