Results 51 to 60 of about 9,382,254 (295)

Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion

Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana, Mariana Maschietto, Daniela Paz Leal, Ricardo de Santos de Oliveira, Mayara Ferreira Euzébio, Antonio Carlos dos Santos, Luciano Neder, Carlos Alberto Scrideli, Elvis Terci Valera   +8 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Effect of research culture on university scientific output: evidence from a structural model in southern Peru

Frontiers in Education
The objective of the study was to analyze the predictive relationship between research culture and scientific output at the National University of Moquegua (UNAM), Peru, during the year 2023. The research is basic in nature, with a quantitative approach,
Jorge Jinchuña Huallpa, Luis Enrique Fernandez Sosa, Javier Pedro Flores Arocutipa, Julio Cesar Lujan Minaya, Maribel Alejandrina Rodriguez Yucra   +4 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Aggregating Scientific Judgment in Scientific Research [PDF]

, 2011
The endeavor to apply the theory of judgment aggregation (TJA) to scientific practice has two main motivating factors. First, this application proceeds from the hope that this new theory could provide a new perspective on well-known problems of the ...
Kunstler, Raphael
core   +2 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Scientific Research

, 2020
Study About Children analysis using computer ...
openaire   +2 more sources

Status of research in the field of engineering in Iran; With a focus on mechanical engineering

آموزش مهندسی ایران, 2019
In this article, the status of research in Iran has been evaluated with a focus on the field of engineering and especially mechanical engineering. To achieve this goal, the quantity and quality of research have been studied and compared with developed ...
Majid Saffar Avval , Mohammad Reza Eslami, Navid Zehtabiyan-Rezaie , Mohammad Hossein Nahavandian   +3 more
doaj   +1 more source

SEAD Virtual Archive: Building a Federation of Institutional Repositories for Long Term Data Preservation [PDF]

, 2012
Major research universities are grappling with their response to the deluge of scientific data emerging through research by their faculty. Many are looking to their libraries and the institutional repository as a solution.
Chandrasekar, Kavitha, Hedstrom, Margaret L., Konkiel, Stacy, Kouper, Inna, Kumar, Praveen, McDonald, Robert H., Myers, Jim, Plale, Beth   +7 more
core   +3 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source