Results 71 to 80 of about 4,856,383 (280)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Polémicas e Modelos para uma Sociologia de Intervenção

open access: yesCadernos de Estudos Africanos, 2003
The sociology of intervention has always defined its central challenge as the utopian search for the key to social change, and using this theoretical reflection, to test methods of reducing uncertainty. This has now produced a long history of theoretical,
Isabel Guerra
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

A Novel Rubric for Rating the Quality of Retraction Notices

open access: yesPublications, 2014
When a scientific article is found to be either fraudulent or erroneous, one course of action available to both the authors and the publisher is to retract said article. Unfortunately, not all retraction notices properly inform the reader of the problems
Emma Bilbrey   +2 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

open access: yesMolecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce   +11 more
wiley   +1 more source

Phenocam - Green and Red Chromatic Coordinates time series from Abisko Scientific Research Station, Mast 4.5m Phenocam 01

open access: yes, 2022
Spectral indices from different ecosystems within the SITES Spectral network, collected by phenocameras on towers. Records are averaged daily from phenocam composites of photos from 10 a.m. to 2 p.m. within specific regions of interest (ROI).
Abisko Scientific Research Station
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Place of scientific research journals in the student research committees

open access: yesپژوهان, 2013
Place of scientific research journals in the student research ...
Hazhir Seifpanahi-sha’bani   +2 more
doaj  

Study of the comprehension of the scientific method by members of a university health research laboratory

open access: yesBrazilian Journal of Medical and Biological Research, 2012
In Brazil, scientific research is carried out mainly at universities, where professors coordinate research projects with the active participation of undergraduate and graduate students. However, there is no formal program for the teaching/learning of the
A.C. Burlamaque-Neto   +6 more
doaj   +2 more sources

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