Interactions of sclerostin with FGF23, soluble klotho and vitamin D in renal transplantation. [PDF]
PLoS ONE, 2017 Relationships of Sclerostin, a bone anti-anabolic protein, with biomarkers of mineral bone disorders in chronic kidney disease are still unsettled, in particular in kidney transplant (KTR).
Lida Tartaglione +7 more
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Sclerostin regulation: a promising therapy for periodontitis by modulating alveolar bone
Chinese Medical Journal, 2020 . Periodontitis is one of the most prevalent epidemics affecting human health and life recently, and exploration of the pathogenesis and treatment of periodontitis has been valued by scholars.
Tian-Jiao Li +5 more
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Serum sclerostin levels are positively related to bone mineral density in peritoneal dialysis patients: a cross-sectional study [PDF]
BMC Nephrology, 2019 Background Sclerostin, an antagonist of the Wingless-type mouse mammary tumor virus integration site (Wnt) pathway that regulates bone metabolism, is a potential contributor of chronic kidney disease (CKD)–mineral and bone disorder (MBD), which has ...
Te-Hui Kuo +7 more
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Decreased Sclerostin Secretion in Humans and Mice With Nonalcoholic Fatty Liver Disease [PDF]
Frontiers in Endocrinology, 2021 ObjectivesGrowing evidence argues for a relationship between liver and bone metabolisms. Sclerostin is a secreted glycoprotein and could antagonize osteoblast-mediated bone formation.
Fangli Zhou +7 more
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Role of sclerostin in mastocytosis bone disease [PDF]
Scientific ReportsMastocytosis is a heterogeneous group of disorders, characterized by accumulation of clonal mast cells which can infiltrate several organs, most often spine (70%). The pathogenesis of mastocytosis bone disease is poorly understood.
Aneta Szudy-Szczyrek +18 more
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Association Between Sclerostin and Sarcopenia-Related Functional Decline in Older Women [PDF]
DiagnosticsBackground: Sclerostin, an osteocyte-derived glycoprotein, plays a key role in bone metabolism by inhibiting the Wnt/β-catenin signaling pathway. While it is a recognized therapeutic target in osteoporosis, its relationship with sarcopenia remains ...
Dong Gyu Lee, Jong Ho Lee, Eunjung Kong
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Association of total and bioactive serum sclerostin levels with bone metabolism in type 2 diabetes mellitus [PDF]
Journal of Clinical & Translational EndocrinologyBackground: Sclerostin has been associated with decreased bone turnover in patients with type 2 diabetes mellitus (T2DM). The relationship with bone turnover markers (BTMs) and bone mineral density (BMD) remains unclear.
Cyril Traechslin +7 more
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Impact of elevated sclerostin levels on bone resorption: unravelling structural changes and mineral metabolism disruption [PDF]
Bone & Joint ResearchAims: The physiological function of sclerostin remains unknown. Sclerostin is synthesized by osteocytes and operates by inhibiting the Wnt/β-catenin pathway. Similarly, it is well established that low levels of sclerostin lead to enhanced bone formation
María Encarnacion Rodríguez-Ortiz +12 more
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Kidney & Blood Pressure Research, 2021 Introduction: Sclerostin could enhance renal excretion of calcium (Ca) and phosphate (P). The association between sclerostin and magnesium (Mg) has not yet discovered.
Ching-Fang Wu +7 more
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B4GALNT3 regulates glycosylation of sclerostin and bone massResearch in context
EBioMedicine, 2023 Summary: Background: Global sclerostin inhibition reduces fracture risk efficiently but has been associated with cardiovascular side effects. The strongest genetic signal for circulating sclerostin is in the B4GALNT3 gene region, but the causal gene is ...
Sofia Movérare-Skrtic +15 more
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