PLoS ONE, 2020 It is known that Wnt/β-catenin signaling induces endochondral ossification and plays a significant role in the pathophysiology of osteoarthritis (OA). Sclerostin is a potent inhibitor of the Wnt/β-catenin signaling pathway.
Kazuma Miyatake +4 more
doaj +1 more source
Genetic evidence that SOST inhibits WNT signaling in the limb [PDF]
, 1987 SOST is a negative regulator of bone formation, and mutations in human SOST are responsible for sclerosteosis. In addition to high bone mass, sclerosteosis patients occasionally display hand defects, suggesting that SOST may function embryonically.
Collette, Nicole M. +4 more
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The Effect Of Light Compressive And Tensile Orthodontics Forces On Sclerostin And Periostin Expressions In Human Periodontal Ligament Cells: An Invitro Study [PDF]
, 2022 Nastaran Sharifi +4 more
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Role of bone-anabolic agents in the treatment of breast cancer bone metastases [PDF]
, 2014 Skeletal metastases are an incurable complication afflicting the majority of patients who die from advanced breast cancer. They are most often osteolytic, characterized by net bone destruction and suppressed new bone formation. Life expectancy from first
Chirgwin, John M., Suvannasankha, Attaya
core +1 more source
Aplidin (plitidepsin) is a novel anti-myeloma agent with potent anti-resorptive activity mediated by direct effects on osteoclasts [PDF]
, 2019 Despite recent progress in its treatment, Multiple Myeloma (MM) remains incurable and its associated bone disease persists even after complete remission.
Atkinson, Emily G. +7 more
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BMC Nephrology, 2018 Background Previous clinical studies found inconsistent relationship between circulating sclerostin levels and treatment outcome in patients undergoing maintenance hemodialysis (MHD).
Aiqun Chen +6 more
doaj +1 more source
Reversal of loss of bone mass in old mice treated with mefloquine [PDF]
, 2018 Aging is accompanied by imbalanced bone remodeling, elevated osteocyte apoptosis, and decreased bone mass and mechanical properties; and improved pharmacologic approaches to counteract bone deterioration with aging are needed.
Allen, Matthew R. +8 more
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Serum Osteocalcin, Sclerostin and Lipocalin-2 Levels in Adolescent Boys with Obesity over a 12-Week Sprint Interval Training [PDF]
, 2023 Marit Salus +8 more
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Osteocyte isolation and culture methods. [PDF]
, 2016 The aim of this paper is to present several popular methods for in vitro culture of osteocytes and osteocyte cell lines. Osteocytes are located extremely suitably within the calcified bone matrix to sense mechanical signals, and are equipped with a ...
Bakker, A.D. +5 more
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The role of sclerostin in knee osteoarthritis and its relation to disease progression
The Egyptian Journal of Internal Medicine, 2019 Background Osteoarthritis (OA) is a common joint disease especially in aging population and is characterized by progressive degeneration of articular cartilage, osteophyte formation, and subsequent joint space narrowing.
Amina B Eldin +2 more
doaj +1 more source