Results 111 to 120 of about 25,148 (309)
BMC Cardiovascular Disorders, 2022 Background Bone-related proteins (such as sclerostin and osteoprotegerin [OPG]) are involved in the development of atherosclerosis. However, the relationship between bone-related proteins and acute myocardial infarction (AMI) has not been extensively ...
X. Shui +7 more
semanticscholar +1 more source
Romosozumab for the treatment of osteoporosis
Osteoporosis and Sarcopenia, 2018 Romosozumab, a specific inhibitor of sclerostin, is a unique approach to therapy for postmenopausal osteoporosis and related disorders. The elucidation of sclerostin deficiency as the molecular defect of syndromes of high bone mass with normal quality ...
Michael R. McClung
doaj +1 more source
Role of key players in paradigm shifts of prostate cancer bone metastasis [PDF]
, 2018 Prostate cancer is one of the most common human cancers and bone metastasis is a frequent finding in the natural history of several types of cancers. The molecular mechanisms that makes prostate cancer metastasize to bone have recently been identified, and
Beg, OA +6 more
core +2 more sources
Inflammatory and Immunological Basis of Periodontal Diseases
Journal of Periodontal Research, EarlyView.The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima +3 more
wiley +1 more source
Cureus, 2022 Background Type 2 diabetes (T2D) is increasing day by day and creating a huge financial and social burden on the Indian population. Insulin resistance results in hyperglycemia, a condition that eventually causes prediabetes and Type 2 diabetes.
P. Singh +4 more
semanticscholar +1 more source
Crosstalk between MLO-Y4 osteocytes and C2C12 muscle cells is mediated by the Wnt/β-catenin pathway [PDF]
, 2017 We examined the effects of osteocyte secreted factors on myogenesis and muscle function. MLO-Y4 osteocyte-like cell conditioned media (CM) (10%) increased ex vivo soleus muscle contractile force by ∼25%. MLO-Y4 and primary osteocyte CM (1-10%) stimulated
Bonewald, Lynda F. +10 more
core +1 more source
The Role of Wnt Signaling in Age‐Related Alveolar Bone Loss and Regeneration
Journal of Periodontal Research, EarlyView.The graphical abstract summarizes key signaling pathways involved in bone formation and resorption associated with Wnt signaling across young and aged long bone and jaw tissues. Levels of evidence are indicated as robust, moderate, or emerging, reflecting the current experimental support in each context.
Hsiao H. Sung +12 more
wiley +1 more source
Physiological Reports, 2022 Sclerostin is a Wnt/β‐catenin antagonist, mainly secreted by osteocytes, and most known for its role in reducing bone formation. Studies in rodents suggest sclerostin can also regulate adipose tissue mass and metabolism, representing bone–adipose tissue ...
N. Kurgan +8 more
semanticscholar +1 more source
Serum markers of bone fragility in type-2 diabetes mellitus [PDF]
, 2019 Patients with type-2 diabetes mellitus (T2DM) have normal or increased bone mineral density (BMD) but despite that, they are characterized by an increased hip and vertebral fracture risk that involves the alteration of bone quality and not the reduction ...
Dănciulescu Miulescu, Rucsandra +5 more
core +1 more source
Osteocytes and Their Messengers as Targets for the Treatment of Multiple Myeloma [PDF]
, 2017 Osteocytes, the most abundant cells in the bone, orchestrate the function of osteoblasts and osteocytes to control physiological bone homeostasis. Accumulating evidence demonstrates that alteration of osteocyte function underlies the pathophysiology of ...
Delgado-Calle, Jesus
core +2 more sources