Results 11 to 20 of about 20,344 (273)
Anti-Sclerostin antibody inhibits internalization of Sclerostin and Sclerostin-mediated antagonism of Wnt/LRP6 signaling. [PDF]
PLoS ONE, 2013 Sclerosteosis is a rare high bone mass disease that is caused by inactivating mutations in the SOST gene. Its gene product, Sclerostin, is a key negative regulator of bone formation and might therefore serve as a target for the anabolic treatment of ...
Maarten van Dinther +10 more
doaj +6 more sources
How accurate is your sclerostin measurement?:Comparison between three commercially available sclerostin ELISA kits [PDF]
Calcified Tissue International, 2016 Sclerostin, bone formation antagonist is in the spotlight as a potential biomarker for diseases presenting with associated bone disorders such as chronic kidney disease (CDK-MBD). Accurate measurement of sclerostin is therefore important.
Fisher, Emily +6 more
core +5 more sources
Advanced Science, EarlyView.Sclerostin loop2‐ApoER2 interaction in macrophages is required by sclerostin to suppress NF‐κB nuclear translocation and phosphorylation, to promote macrophage conversion into anti‐inflammatory subtypes in atherosclerotic aortas, as well as to prevent atherosclerosis and aortic aneurysm development in ApoE−/− mice. Abstract Therapeutic antibody against
Luyao Wang +27 more
wiley +2 more sources
Sclerostin and Vascular Pathophysiology [PDF]
International Journal of Molecular Sciences, 2020 There is cumulating evidence for a contribution of Wnt signaling pathways in multiple processes involved in atherosclerosis and vascular aging. Wnt signaling plays a role in endothelial dysfunction, in the proliferation and migration of vascular smooth muscle cells (VSMCs) and intimal thickening.
Catalano A. +3 more
openaire +3 more sources
Endocrine Functions of Bone Are Suppressed by Orally Administered Glucose Regardless of Bodyweight. [PDF]
Clin Endocrinol (Oxf)ABSTRACT Objective Bone is a target for diabetic complications, but the impact of metabolic changes on bone metabolism is less understood. Bones participate in energy metabolism by via secreted osteokines. Glucose ingestion reduces bone resorption, but the effects on osteokines remain unknown. Further, it is not known whether the response is altered in
Jalava N +4 more
europepmc +2 more sources
Sclerostin promotes human dental pulp cells senescence [PDF]
PeerJ, 2018 Background Senescence-related impairment of proliferation and differentiation limits the use of dental pulp cells for tissue regeneration. Deletion of sclerostin improves the dentinogenesis regeneration, while its role in dental pulp senescence is ...
Yanjing Ou +3 more
doaj +2 more sources
Does oxidative status affect serum sclerostin levels in patients with type 2 diabetes mellitus? [PDF]
Folia Medica, 2023 Introduction: Sclerostin is a glycoprotein known as a negative regulator of bone formation, predominantly expressed by mature osteocytes.
Ilhan Sabancilar +4 more
doaj +3 more sources
Cardiovascular Safety of Anti-Sclerostin Therapy in Chronic Kidney Disease
Metabolites, 2021 The significance of sclerostin for bone and cardiovascular health in patients with chronic kidney disease (CKD) is complex and incompletely understood. Experimental evidence suggests that anti-sclerostin therapy shows diminished efficacy on bone in the ...
Daniel Cejka
doaj +1 more source
Sclerostin is upregulated in the early stage of chondrogenic differentiation, but not required in endochondral ossification in vitro. [PDF]
PLoS ONE, 2018 Sclerostin is a potent inhibitor of the canonical Wnt signaling pathway. Wnt signaling pathways have multiple roles in the regulation of cartilage development, growth, and maintenance.
Yasuteru Yamaguchi +4 more
doaj +1 more source
eLife, 2021 The downregulation of sclerostin in osteocytes mediates bone formation in response to mechanical cues and parathyroid hormone (PTH). To date, the regulation of sclerostin has been attributed exclusively to the transcriptional downregulation of the Sost ...
Nicole R Gould +11 more
doaj +1 more source