Results 31 to 40 of about 25,148 (309)
Interactions of sclerostin with FGF23, soluble klotho and vitamin D in renal transplantation [PDF]
, 2017 Relationships of Sclerostin, a bone anti-anabolic protein, with biomarkers of mineral bone disorders in chronic kidney disease are still unsettled, in particular in kidney transplant (KTR).
Farcomeni, Alessio +7 more
core +15 more sources
Sclerostin and Vascular Pathophysiology [PDF]
International Journal of Molecular Sciences, 2020 There is cumulating evidence for a contribution of Wnt signaling pathways in multiple processes involved in atherosclerosis and vascular aging. Wnt signaling plays a role in endothelial dysfunction, in the proliferation and migration of vascular smooth muscle cells (VSMCs) and intimal thickening.
Catalano A. +3 more
openaire +3 more sources
Nature Communications, 2022 Sclerostin negatively regulates bone formation by antagonizing Wnt signalling. An antibody targeting sclerostin for the treatment of postmenopausal osteoporosis was approved by the U.S.
Yuanyuan Yu +24 more
semanticscholar +1 more source
Kidney & Blood Pressure Research, 2021 Introduction: Sclerostin could enhance renal excretion of calcium (Ca) and phosphate (P). The association between sclerostin and magnesium (Mg) has not yet discovered.
Ching-Fang Wu +7 more
doaj +1 more source
Novel insights on the effect of sclerostin on bone and other organs.
Journal of Endocrinology, 2023 As a key regulator of bone homeostasis, sclerostin has garnered a lot of interest over the last two decades. Although sclerostin is primarily expressed by osteocytes and is well known for its role in bone formation and remodelling, it is also expressed ...
Timothy Dreyer +3 more
semanticscholar +1 more source
Sclerostin promotes human dental pulp cells senescence [PDF]
PeerJ, 2018 Background Senescence-related impairment of proliferation and differentiation limits the use of dental pulp cells for tissue regeneration. Deletion of sclerostin improves the dentinogenesis regeneration, while its role in dental pulp senescence is ...
Yanjing Ou +3 more
doaj +2 more sources
Cardiovascular Safety of Anti-Sclerostin Therapy in Chronic Kidney Disease
Metabolites, 2021 The significance of sclerostin for bone and cardiovascular health in patients with chronic kidney disease (CKD) is complex and incompletely understood. Experimental evidence suggests that anti-sclerostin therapy shows diminished efficacy on bone in the ...
Daniel Cejka
doaj +1 more source
Does oxidative status affect serum sclerostin levels in patients with type 2 diabetes mellitus? [PDF]
Folia Medica, 2023 Introduction: Sclerostin is a glycoprotein known as a negative regulator of bone formation, predominantly expressed by mature osteocytes.
Ilhan Sabancilar +4 more
doaj +3 more sources
Sclerostin is upregulated in the early stage of chondrogenic differentiation, but not required in endochondral ossification in vitro. [PDF]
PLoS ONE, 2018 Sclerostin is a potent inhibitor of the canonical Wnt signaling pathway. Wnt signaling pathways have multiple roles in the regulation of cartilage development, growth, and maintenance.
Yasuteru Yamaguchi +4 more
doaj +1 more source
Sclerostin blockade promotes bone metastases of Wntâresponsive breast cancer cells
Cancer Science, 2023 The secreted protein sclerostin is primarily produced by osteocytes and suppresses osteoblast differentiation and function by inhibiting the canonical Wnt signaling pathway.
T. Hiraga +4 more
semanticscholar +1 more source