Results 101 to 110 of about 34,687 (233)

Bibliometric Analysis of Cubebenes and Related Sesquiterpenes: Natural Occurrence, Biosynthesis, Pharmacological Activities, and In‐Silico‐Based Future Therapeutic Potential

eFood, Volume 7, Issue 3, June 2026.
Cubebene‐related sesquiterpenes, found across diverse biological sources, exhibit promising pharmacological activities, including anti‐inflammatory, neuroprotective, and anticancer effects. This review highlights their molecular diversity, ADME profiles, and predicted multitarget interactions, underscoring their therapeutic relevance and potential in ...
Khadija Boualam, Ahmet B. Ortaakarsu, Sohaib Khatib, Mohamed A. Farag, Mansour Sobeh   +4 more
wiley   +1 more source

SIRT1 Prevents Ferroptosis in Corneal Epithelial Cells by Enhancing HIF1α Protein Stability in Dry Eye Disease

Advanced Science, Volume 13, Issue 26, 8 May 2026.
Hyperosmotic stress drives ferroptosis in corneal epithelium via SIRT1 downregulation. This work demonstrates that SIRT1 activation stabilizes HIF1α, which transcriptionally upregulates GPX4 to inhibit lipid peroxidation and cell death. The identified SIRT1/HIF1α/GPX4 axis reveals a novel defense mechanism and potential therapy for dry eye disease ...
Lili Lian, Zhenmin Le, Xuanqiao Ye, Zimo Wang, Jiuxiao Li, Chenyu Dong, Yetao Shen, Jiazheng Li, Yueping Ren, Xiaoyin Ma, Wei Chen, Qinxiang Zheng   +11 more
wiley   +1 more source

Preventive Effect of Gallic Acid‐Loaded Carrageenan Nanoparticles Against Cerebral Ischemia/Reperfusion Injury in Rat: Modulation of Oxidative Pathway

Food Science &Nutrition, Volume 14, Issue 5, May 2026.
Oral pretreatment with GA‐CG NPs provided remarkable neuroprotection in a rat model of cerebral ischemia/reperfusion. GA‐CG NPs improved cognition and attenuated depressive‐like behaviors, infarct volume, MDA content, as well as increased dopamine and antioxidant status (SOD, CAT, GPx, GSH) compared with free gallic acid.
Akbar Hajizadeh Moghaddam, Parisa Jahani Bahnamiri, Sedigheh Khanjani Jelodar, Zohre Fendereski Jaz, Parisa Nasiriansari, Vahid Hasantabar   +5 more
wiley   +1 more source

Transdermal and Powdered Scopolamine-Induced Anisocoria: A Report of Two Cases

Case Reports in Ophthalmology
Introduction: In this case report, we present 2 cases of sudden-onset anisocoria caused by accidental exposure to scopolamine in 2 young female patients. Case Presentation: Two patients presented with unilateral anisocoria.
Leyan Li, Lili Lian, Rong Zhou
doaj   +1 more source

The effect of drugs in altering susceptibility to motion sickness in aerobatics and the slow rotation room [PDF]

Drugs altering susceptibility to motion sickness in aerobatics and slow rotation ...
Cawrse, A. C., Deane, F. R., Graybiel, A., Wood, C. D.   +3 more
core   +1 more source

2025 Consensus Clinical Management Guidelines for Niemann‐Pick Disease Type C

Journal of Inherited Metabolic Disease, Volume 49, Issue 3, May 2026.
ABSTRACT In 2018, the International Niemann‐Pick Disease Alliance (INPDA) and the International Niemann‐Pick Disease Registry (INPDR) developed and published comprehensive clinical management guidelines to support inclusive and standardized care pathways in Niemann‐Pick disease type C (NPC)—an ultra‐rare, autosomal recessive, neurovisceral lysosomal ...
Tarekegn Hiwot, Forbes D. Porter, Tatiana Bremova‐Ertl, Uma Ramaswami, Caroline Hastings, Bénédicte Héron, Justin Hopkin, Joella Melville, Hernan Amartino, Mireia del Toro, Federica Deodato, Fatih Ezgü, Paul Gissen, James B. Gibson, Can Ficicioglu, Roberto Giugliani, Orna Staretz‐Chacham, Frances Platt, Nathalie Guffon, Kristina Julich, Nikola Kresojević, Anna Lehman, Yann Nadjar, Susanne A. Schneider, Simon Jones, Eugen Mengel, Michel Tchan, Mark Walterfang, Ozlem Goker‐Alpan, Charlotte Dawson, Sandra Cowie, Toni Mathieson, Elizabeth Berry‐Kravis, Marc C. Patterson   +33 more
wiley   +1 more source

Exploring Linalool‐Based Phytotherapy for Excitatory/Inhibitory Imbalance in Alzheimer's Disease: A Review of Lavender and Cannabis Therapeutic Effects on Sleep, Seizures, and Cognition

Phytotherapy Research, Volume 40, Issue 5, Page 2604-2631, May 2026.
Schematic overview of the proposed neuromodulatory actions of linalool in Alzheimer's disease. Through multi‐target effects on oxidative stress, amyloid aggregation, GABAergic and glutamatergic signaling, linalool may restore excitatory/inhibitory balance.
Ilaria Piccialli, Giovanni Roviello, Giorgia Magliocca, Emilia Esposito, Anna Pannaccione   +4 more
wiley   +1 more source

TAK-071, a muscarinic M1 receptor positive allosteric modulator, attenuates scopolamine-induced quantitative electroencephalogram power spectral changes in cynomolgus monkeys.

PLoS ONE, 2019
Activation of the muscarinic M1 receptor is a promising approach to improve cognitive deficits associated with cholinergic dysfunction in Alzheimer's disease, dementia with Lewy bodies, and schizophrenia.
Emi Kurimoto, Masato Nakashima, Haruhide Kimura, Motohisa Suzuki   +3 more
doaj   +1 more source

Xanthatin‐13‐(Pyrrolidine‐2‐Carboxylic Acid), a Sesquiterpene Lactone Isolated From Burdock Leaf, Attenuated Aβ25‐35 Toxicity and Memory Deficits in a Pharmacological Mouse Model of Alzheimer's Disease

Phytotherapy Research, Volume 40, Issue 5, Page 2824-2843, May 2026.
ABSTRACT Alzheimer's disease (AD) is a severe form of dementia, which occurrence increases with age and lifestyle conditions. It is characterized by amyloid protein accumulation forming senile plaques, hyperphosphorylated tau protein forming neurofibrillary tangles, neuroinflammation, and oxidative stress, leading to synapse loss and cell death ...
Charlyne Barry‐Simonnet, Lucie Crouzier, Tristan Moujellil‐Legagneur, Hamza Chaieb‐Errass, Yanis A. Idres, Karine Ferrare, Marc Rolland, Guillaume Cazals, Patrick Poucheret, Tangui Maurice, Didier Tousch   +10 more
wiley   +1 more source

Ethanolic extract of Actinidia chinensis var. delicious fruit ameliorates scopolamine-induced cognitive impairment in rats

Pharmacological Research - Modern Chinese Medicine
Aim: The present study was to assess the anti-amnesic effect of Actinidia chinensis var deliciosa in a rat model of scopolamine-induced amnesia. Method: 36 rats were divided into 6 groups and assigned name to each group i.e. Group 1 rats (normal control)
Shireen Ansari, Sushmita Uniyal, Ayushi Khali, Rishabh Gaur, Karabi Kalita   +4 more
doaj   +1 more source