Results 41 to 50 of about 17,647 (177)
Dualsteric and dual‐acting modulation of muscarinic receptors by antagonist KH‐5
British Journal of Pharmacology, EarlyView.Abstract Background and purpose Muscarinic acetylcholine receptors are key therapeutic targets, and ligands engaging both orthosteric and allosteric sites may offer improved selectivity and efficacy. Here, we investigated whether the muscarinic antagonist KH‐5 acts as a dualsteric antagonist and defined its mode of interaction with muscarinic receptors.
Alena Janoušková‐Randáková +3 more
wiley +1 more source
Muscarinic agonists for schizophrenia: Bridging preclinical evidence and clinical enthusiasm
British Journal of Pharmacology, EarlyView.Abstract Antipsychotic drugs targeting dopamine receptors have been used to treat schizophrenia for decades, primarily alleviating positive symptoms such as hallucinations and delusions. However, they provide limited benefit for cognitive and negative symptoms—major contributors to poor outcomes—and are frequently associated with significant side ...
Brian J. Morris, Judith A. Pratt
wiley +1 more source
Internal Medicine Journal, EarlyView.Abstract Background Palliative care patients experience complex symptoms requiring varied pharmacological management. Medication choice depends on the underlying aetiology of symptoms, guideline recommendations, clinician preference and medication availability.
Jack Power +10 more
wiley +1 more source
Is sleep affected after microgravity and hypergravity exposure? A pilot study
Journal of Sleep Research, Volume 34, Issue 2, April 2025.Summary Sleep is known to be affected in space travel and in residents of the international space station. But little is known about the direct effects of gravity changes on sleep, if other factors, such as sleep conditions, are kept constant. Here, as a first exploration, we investigated sleep before and after exposure to short bouts of microgravity ...
Barbara Le Roy +9 more
wiley +1 more source
Cholinergic control of visual categorisation in macaques
Frontiers in Behavioral Neuroscience, 2011 Acetylcholine (ACh) is a neurotransmitter acting via muscarinic and nicotinic receptors that is implicated in several cognitive functions and impairments, such as Alzheimer’s disease. It is believed to especially affect the acquisition of new information,
Nikolaos C. Aggelopoulos +5 more
doaj +1 more source
Plant Biotechnology Journal, EarlyView.ABSTRACT Efficient purification remains a key technical challenge affecting the recovery efficiency of recombinant proteins in plant‐based systems. Complex metabolites, particularly polyphenols, often cause recombinant protein aggregation during purification.
Hai‐Ping Diao +7 more
wiley +1 more source
Zagazig Journal of Pharmaceutical Sciences, 2013 Most of the current evidence for the impact of piracetam on memory consolidation originates from animal and human studies. However, the exact mechanism that underlies memory improvement is yet to be determined.
Ibrahim Alhaider
doaj +1 more source
مجله دانشگاه علوم پزشکی گرگان, 2020 Background and Objective: Alzheimer is the most common form of dementia in elderly persons. Oxidative stress is one of the main pathological factors in Alzheimer’s disease.
Hamidreza Sameni +5 more
doaj
Ameliorating the effect of Zingiber officinale (ginger) hydroethanolic extract on scopolamine-induced memory impairment in adult male rats [PDF]
Advanced Herbal Medicine, 2016 Background and aims: The spice Zingiber officinale or ginger possesses antioxidant and neuroprotective effects. In this study we hypothesized that treatment with hydroethanolic extract of ginger (50, 100 and 200 mg/kg, p.o) would have an effect on the ...
Abdolkarim Hosseini +3 more
doaj
Química Nova, 2014 A simple procedure is described for the determination of scopolamine by square-wave voltammetry using a cathodically pretreated boron-doped diamond electrode. Cyclic voltammetry studies indicate that the oxidation of scopolamine is irreversible at a peak
Simone Birkheur Santos +5 more
doaj +1 more source