Results 61 to 70 of about 34,687 (233)

Effect of crocin on histological changes of hippocampus and memory impairment induced by scopolamine in male rats

مجله دانشگاه علوم پزشکی گرگان, 2020
Background and Objective: Alzheimer is the most common form of dementia in elderly persons. Oxidative stress is one of the main pathological factors in Alzheimer’s disease.
Hamidreza Sameni, Afsaneh Talebian, Abbas Ali Vafaei, Sam Zarbakhsh, Zahra Yaghoubi, Mohammadreza Aldaghi   +5 more
doaj  

Antidepressant and anxiolytic activity of Lavandula officinalis aerial parts hydroalcoholic extract in scopolamine-treated rats

Pharmaceutical Biology, 2017
Context: Anxiety and depression are common in Alzheimer’s disease (AD). Despite some evidence, it is difficult to confirm Lavandula officinalis Chaix ex Vill (Lamiaceae) as an anxiolytic and antidepressant drug. Objective: The effects of L.
Batool Rahmati, Zahra Kiasalari, Mehrdad Roghani, Mohsen Khalili, Fariba Ansari   +4 more
doaj   +1 more source

Nacre extract prevents scopolamine-induced memory deficits in rodents

Asian Pacific Journal of Tropical Medicine, 2018
Objective: To investigate whether the extract from the nacreous layer of pearl oysters (nacre extract) improves impairments in memory caused by scopolamine administration in rodents. Methods: Nacre extract was prepared from the inner shell layer of pearl
Tatsuya Fuji, Tatsurou Inoue, Yasushi Hasegawa   +2 more
doaj   +1 more source

Molecular descriptor driven QSPR modeling of Papp, TEER and Efflux Ratio from Caco‐2 cells using machine learning for various phytochemicals

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND The present study aimed to develop and validate quantitative structure–property relationship (QSPR) models for predicting permeability related bioavailability indicators including apparent permeability (Papp), trans‐epithelial electrical resistance (TEER) and efflux ratio (ER) based on molecular descriptors (n = 5003) of 83 ...
Jin‐Woo Kim, Rixing Cong, Jin‐Soo Park, Keunwan Park, Kyungsu Kang, Soon‐Mi Shim   +5 more
wiley   +1 more source

Ameliorating the effect of Zingiber officinale (ginger) hydroethanolic extract on scopolamine-induced memory impairment in adult male rats [PDF]

Advanced Herbal Medicine, 2016
Background and aims: The spice Zingiber officinale or ginger possesses antioxidant and neuroprotective effects. In this study we hypothesized that treatment with hydroethanolic extract of ginger (50, 100 and 200 mg/kg, p.o) would have an effect on the ...
Abdolkarim Hosseini, Ali Gomar, Naser Mirazi, Mojtaba Gomar   +3 more
doaj  

Neuroprotection of N-benzylcinnamide on scopolamine-induced cholinergic dysfunction in human SH-SY5Y neuroblastoma cells

Neural Regeneration Research, 2017
Alzheimer's disease, a progressive neurodegenerative disease, affects learning and memory resulting from cholinergic dysfunction. Scopolamine has been employed to induce Alzheimer's disease-like pathology in vivo and in vitro through alteration of ...
Nicha Puangmalai, Wipawan Thangnipon, Rungtip Soi-ampornkul, Nirut Suwanna, Patoomratana Tuchinda, Saksit Nobsathian   +5 more
doaj   +1 more source

A systematic review of performance-enhancing pharmacologicals and biotechnologies in the Army [PDF]

, 2018
INTRODUCTION: In 2015, the Australian Army commissioned a systematic review to assess the evidence on effectiveness and safety of pharmacological and biotechnological products for cognitive enhancement specifically in Army personnel.METHODS: Searches for
Ayson, Mark, Hunter, K E, Ko, Henry, Scott, A M, Willson, M L   +4 more
core   +1 more source

Exocrine Gland Dysfunction in Parkinson's Disease: Pathophysiology, Clinical Manifestations, and Therapeutic Perspectives—A Narrative Review

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Non‐motor symptoms, especially autonomic dysfunction, are major contributors to disability and decreased quality of life in Parkinson's disease (PD). Despite being common and having a wide range of clinical facets, exocrine gland dysfunction is still not well recognized and managed.
Renato P. Munhoz, Marina Farah, Laura Silveira‐Moriyama   +2 more
wiley   +1 more source

Single prazosin infusion in prelimbic cortex Fosters extinction of amphetamine-induced conditioned place preference [PDF]

, 2017
Exposure to drug-associated cues to induce extinction is a useful strategy to contrast cue-induced drug seeking. Norepinephrine (NE) transmission in medial prefrontal cortex has a role in the acquisition and extinction of conditioned place preference ...
Alessandro Rava, Emanuele C. Latagliata, Giulia Chiacchierini, Luisa Lo Iacono, Luisa Lo Iacono, Marco Sancandi, Stefano Puglisi-Allegra, Stefano Puglisi-Allegra, Valeria Oliva   +8 more
core   +4 more sources

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source