Results 71 to 80 of about 17,592 (189)

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, Volume 46, Issue 4, Page 1173-1229, July 2026.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Behavioral and Biochemical Effects of an Arylhydrazone Derivative of 5-Methoxyindole-2-Carboxylic Acid in a Scopolamine-Induced Model of Alzheimer’s Type Dementia in Rats

Molecules
Alzheimer’s disease (AD) has long proven to be a complex neurodegenerative disorder, with cholinergic dysfunction, oxidative stress, and neuroinflammation being just a few of its pathological features.
Polina Petkova-Kirova, Neda Anastassova, Borislav Minchev, Diamara Uzunova, Valya Grigorova, Elina Tsvetanova, Almira Georgieva, Albena Alexandrova, Miroslava Stefanova, Denitsa Yancheva, Reni Kalfin, Lyubka Tancheva   +11 more
doaj   +1 more source

Clinical pharmacology and prescribing education: An updated medical school curriculum from the British Pharmacological Society

British Journal of Clinical Pharmacology, Volume 92, Issue 6, Page 1787-1808, June 2026.
Aims Prescribing is a complex, essential skill that doctors must acquire to practice medicine safely and effectively. The British Pharmacological Society has historically provided a core curriculum to guide clinical pharmacology and prescribing education in UK medical schools.
Dagan O. Lonsdale, Clare Guilding, Jennifer Koenig, Michael Okorie, Reecha Sofat, Simon Maxwell   +5 more
wiley   +1 more source

Determining the Antioxidant Properties of Chamomile and Investigating the ‎Effects of Chamomile Ethanol Extract on Motor Coordination Disorders in Rats ‎

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2015
BACKGROUND AND OBJECTIVE: Alzheimer’s, a progressive disorder causing the memory and other crucial functions of the brain to deteriorate, is mainly responsible for Dementia (brain deterioration).
Z Rabiei, Z Alibabaei, M Rafieian-kopaei
doaj  

Anti‐Obesity Pharmacotherapy and Emerging Multimodal Interventions for Obstructive Sleep Apnea

Chronic Diseases and Translational Medicine, Volume 12, Issue 2, Page 100-112, June 2026.
Cellular and molecular mechanisms of obesity‐related obstructive sleep apnea (OSA). ADMA: asymmetric dimethyrarginine, NLRP3: nucleotide‐binding domain, leucine‐rich repeat family, Pyrin domain containing 3, TLR: toll‐like receptors, IL‐1β: interleukin‐1β, IL‐6: interleukin‐6; LPS: lipopolysacharide, ROS: reactive oxygen species, TNF‐α.
Anish Preshy, Cornelius J. Fernandez, Mohammad Hamid Nedai, Joseph M. Pappachan   +3 more
wiley   +1 more source

The Effect of Transdermal Scopolamine for the Prevention of Postoperative Nausea and Vomiting

Frontiers in Pharmacology, 2014
Postoperative nausea and vomiting is one of the most common and undesirable complaints recorded in as many as 70%-80% of high-risk surgical patients. The current prophylactic therapy recommendations for PONV management stated in the Society of Ambulatory
Maria A. Antor, Alberto A Uribe, Nataly eErminy, Joseph G. Werner, Keith A. Candiotti, Joseph V. Pergolizzi, Sergio Daniel Bergese, Sergio Daniel Bergese   +7 more
doaj   +1 more source

Standardized Pipeline for Metabolism and Cognition in GO‐DS21 Mouse Model: Investigating Down Syndrome Comorbidities

Current Protocols, Volume 6, Issue 6, June 2026.
Abstract Down syndrome (DS) is the most prevalent form of intellectual disability (ID) globally, with an incidence rate of approximately 1 in 1000 births, affecting over 5 million individuals worldwide. DS is characterized by a genetic profile that predisposes individuals to a range of medical and cognitive conditions, including ID and obesity, which ...
Mohammed Selloum, Patricia da Silva‐Buttkus, Fabrice Riet, Nathalia R. V. Dragano, Lillian Garrett, Hugues Jacobs, Sabine M. Hölter, Nicolas Torquet, Birgit Rathkolb, Loic Lindner, Valerie Gailus‐Durner, Guillaume Pavlovic, Li Chan, Johannes Beckers, Benoit Petit Demoulière, Helmut Fuchs, Elodie Ey, Tania Sorg, Martin Hrabe de Angelis, Yann Herault, the GO‐DS21 Consortium   +20 more
wiley   +1 more source

Vitamin E can compensate the density of M1 receptors in the hippocampus of scopolamine-treated rats

Folia Neuropathologica, 2018
M1 muscarinic receptor plays a fundamental role in memory and is closely associated with Alzheimer’s disease (AD); it has long been assumed as a therapeutic goal. By activating of the cholinergic receptor vitamin E helps with memory retention.
Ali Sayyahi, Mehrdad Jahanshahi, Hossein Amini, Hamid Sepehri   +3 more
doaj   +1 more source

Bibliometric Analysis of Cubebenes and Related Sesquiterpenes: Natural Occurrence, Biosynthesis, Pharmacological Activities, and In‐Silico‐Based Future Therapeutic Potential

eFood, Volume 7, Issue 3, June 2026.
Cubebene‐related sesquiterpenes, found across diverse biological sources, exhibit promising pharmacological activities, including anti‐inflammatory, neuroprotective, and anticancer effects. This review highlights their molecular diversity, ADME profiles, and predicted multitarget interactions, underscoring their therapeutic relevance and potential in ...
Khadija Boualam, Ahmet B. Ortaakarsu, Sohaib Khatib, Mohamed A. Farag, Mansour Sobeh   +4 more
wiley   +1 more source

The neuroprotective effects of Ocimum gratissimum-supplemented diet on scopolamine-induced memory impairment in mice model of Alzheimer’s Disease

Phytomedicine Plus
Background: Cognitive decline is a hallmark of Alzheimer's disease, a progressive neurodegenerative illness primarily caused by the buildup of amyloid plaque, which is brought on by oxidative stress and neuroinflammation.
Damilare Alabi Akanbi, Patrick Olanrewaju Ogboriga, Ismaheel Akinwale Adeniyi, Akintunde Muthoir Lawal, Michael Ayomikun Olusola, Precious Ayomiposi Oluyemi, Samuel Adetunji Onasanwo   +6 more
doaj   +1 more source