Results 141 to 150 of about 291,183 (179)

A novel chalcone derivative as Nrf2 activator attenuates learning and memory impairment in a scopolamine-induced mouse model

European Journal of Medicinal Chemistry, 2019
Alzheimer's disease is a common neurodegenerative disease characterized by progressive degeneration and neuronal cell death, resulting in neural network dysfunction. As the underlying mechanisms, oxidative damage and neuroinflammation have been reported to contribute to the onset and deterioration of Alzheimer's disease.
Hyeon Jeong Kim, Bo Ko Jang, Jong‐Hyun Park, Jin‐Sung Choi, Sun Jun Park, Seong Rim Byeon, Ae Nim Pae, Yong Sup Lee, Eunji Cheong, Ki Duk Park   +9 more
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The novel dehydroepiandrosterone (DHEA) derivative BNN27 counteracts delay-dependent and scopolamine-induced recognition memory deficits in rats

Neurobiology of Learning and Memory, 2017
Experimental evidence indicates that the neurosteroids dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulphate (DHEAS) are involved in cognition. BNN27 is a novel 17C spiroepoxy-DHEA derivative, which devoid of steroidogenic activity. The neuroprotective effects of BNN27 have been recently reported.
Nikolaos Pitsikas, Achille Gravanis
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Somaclonal Variation of Scopolamine Content in Protoplast-Derived Cell Culture Clones ofHyoscyamus muticus

Planta Medica, 1986
We have established clonal cell cultures derived from protoplasts of haploid and diploid Hyoscyamus muticus L. var. Gatersleben (Solanaceae) plants. The scopolamine content of plants and the clones was determined by sensitive enzyme- and radioimmunoassay. Variation in scopolamine content was significant among whole plants.
André Strauss, Kirsi-Marja Oksman-Caldentey   +1 more
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Neuroprotective effects of novel pyrrolidine-2-one derivatives on scopolamine-induced cognitive impairment in mice: Behavioral and biochemical analysis

Pharmacology Biochemistry and Behavior, 2023
Alzheimer's disease (AD) is a long-term neurodegenerative condition that impairs cognitive abilities. In brain acetylcholine deficit and oxidative stress may be considered the key pathogenic causes for AD, even though the basic etiology is still unknown.
Swati Pant, Mohan L. Gupta, Tulika Anthwal, Monika Chauhan, Sumitra Nain   +4 more
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Design and development of 1,3,4-oxadiazole derivatives as potential inhibitors of acetylcholinesterase to ameliorate scopolamine-induced cognitive dysfunctions

Bioorganic Chemistry, 2019
The novel hybrids bearing 4-aminopyridine (4-AP) tethered with substituted 1,3,4-oxadiazole nucleus were designed, synthesized, and evaluated for their potential AChE inhibitory property along with significant antioxidant potential. The inhibitory potential (IC50) of synthesized analogs was evaluated against human cholinesterases (hAChE and hBChE ...
Puja Mishra, Ankit Seth, Sushant K. Shrivastava, Prabhash Nath Tripathi, Piyoosh Sharma, Avanish Tripathi, Pavan Srivastava, Sukesh Kumar Gupta, Sairam Krishnamurthy   +8 more
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Sea Cucumber-Derived Peptide Attenuates Scopolamine-Induced Cognitive Impairment by Preventing Hippocampal Cholinergic Dysfunction and Neuronal Cell Death

Journal of Agricultural and Food Chemistry, 2022
The incidence of neurodegenerative diseases related to cognitive decline and memory loss is on the rise as the global elderly population increases. In this study, we evaluated the effect of the sea cucumber-derived peptide Phe-Tyr-Asp-Trp-Pro-Lys (FYDWPK) on scopolamine-induced neurotoxicity in an animal model.
Yue Zhao, Zhiqiang Lu, Xiaomeng Xu, Na Sun, Songyi Lin   +4 more
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[The effect of quaternary derivatives of scopolamine (cimetropium bromide) on intestinal motility].

Bollettino chimico farmaceutico, 1986
A. Sagrada, Achille Schiavone, Luigi Cervo, Antonio Giachetti   +3 more
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In Vitro and In Vivo Investigations of Chromone Derivatives as Potential Multitarget-Directed Ligands: Cognitive Amelioration Utilizing a Scopolamine-Induced Zebrafish Model

ACS Chemical Neuroscience
Alzheimer's disease is a complex neurological disorder linked with multiple pathological hallmarks. The interrelation of therapeutic targets assists in the enhancement of cognitive decline through interference with overall neuronal transmission. We have synthesized and screened various chromone derivatives as potential multitarget-directed ligands for ...
Naveen Kumar, Kailash Jangid, Vishal Kumar, Ravi Prakash Yadav, Jayapriya Mishra, Shubham Upadhayay, Vinay Kumar, Bharti Devi, Vijay Kumar, Ashish Ranjan Dwivedi, Puneet Kumar, Somesh Baranwal, Jasvinder Singh Bhatti, Vinod Kumar   +13 more
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Substituted Aminobenzothiazole Derivatives of Tacrine: Synthesis and Study on Learning and Memory Impairment in Scopolamine-Induced Model of Amnesia in Rat

Mini-Reviews in Medicinal Chemistry, 2018
Background:Currently, there is no conclusive cure for Alzheimer’s disease (AD) and existing treatments mainly offer symptomatic relief. Dysfunction of the cholinergic system plays an important role in the pathogenesis of AD. Tacrine (1, 2, 3, 4-tetrahydroacridin-9-amine, III) was the first approved agent for the palliative therapy of AD but its use is ...
Abbas Ahmadi, Mehrdad Roghani, S Keshavarz Noori, Babak Nahri-Niknafs   +3 more
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Bone Marrow-Derived Endothelial Progenitor Cells Protect Against Scopolamine-Induced Alzheimer-Like Pathological Aberrations

Molecular Neurobiology, 2014
Vascular endothelial dysfunction plays a key role in the pathogenesis of Alzheimer's disease (AD). Patients with AD have displayed decreased circulating endothelial progenitor cells (EPCs) which repair and maintain the endothelial function. Transplantation of EPCs has emerged as a promising approach for the management of cerebrovascular diseases ...
Safar, Marwa M., Arab, Hany H., Rizk, Sherine M., El-Maraghy, Shohda A.   +3 more
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