Results 161 to 170 of about 1,353,799 (209)

Therapeutic Options in Alzheimer's Disease: From Classic Acetylcholinesterase Inhibitors to Multi-Target Drugs with Pleiotropic Activity. [PDF]

Life (Basel)
Cacabelos R, Martínez-Iglesias O, Cacabelos N, Carrera I, Corzo L, Naidoo V.   +5 more
europepmc   +1 more source

Reprogramming Hairy Root Cultures: A Synthetic Biology Framework for Precision Metabolite Biosynthesis. [PDF]

Plants (Basel)
Liu C, Ahmad N, Tao Y, Hussain H, Chang Y, Umar AW, Liu X.   +6 more
europepmc   +1 more source

Bioactive Profiling and Anti-Hyperglycemic Potential of <i>Berberis nummularia</i> Bunge: Role of Polyphenols and α-Amylase Inhibition. [PDF]

Foods
Abudureheman B, Chen L, Zhang J, Zhu S, Wang J, Huang J, Xie C, Pan H, Ye X.   +8 more
europepmc   +1 more source

Gallic Acid, 3-Hydroxytyrosol, and Quercetin Modulate Cholinesterase Activity in Drosophila melanogaster. [PDF]

Int J Mol Sci
Ucar Akyurek T, Senol Deniz FS, Erdogan Orhan I, Gozuboyuk M, Erdemli GI, Emecen G.   +5 more
europepmc   +1 more source

Positive AMPA and Kainate Receptor Modulators and Their Therapeutic Potential in CNS Diseases: A Comprehensive Review. [PDF]

Int J Mol Sci
Vialko A, Chałupnik P, Szymańska E.
europepmc   +1 more source

Neuroprotective Effects of Cilomilast and Chlorogenic Acid Against Scopolamine-Induced Memory Deficits via Modulation of the cAMP/PKA-CREB-BDNF Pathway. [PDF]

Int J Mol Sci
Mosalam EM, Atya SM, Mesbah NM, Allam S, Mehanna ET.   +4 more
europepmc   +1 more source

Correction: Prescribing Cascades with Recommendations to Prevent or Reverse Them: A Systematic Review. [PDF]

Drugs Aging
Adrien O, Mohammad AK, Hugtenburg JG, McCarthy LM, Priester-Vink S, Visscher R, van den Bemt PMLA, Denig P, Karapinar-Carkıt F.   +8 more
europepmc   +1 more source

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Effects of New Galantamine Derivatives in a Scopolamine Model of Dementia in Mice

Journal of Alzheimer's Disease, 2021
Alzheimer’s disease (AD), a progressive neurodegenerative disorder characterized by memory loss and cognitive functions decline, is a leading cause for dementia and currently ranked as the sixth foremost cause of death. As of present, treatment of AD is symptomatic without convincing therapeutic benefits and new, effective, therapeutic agents are ...
Maria, Lazarova, Lyubka, Tancheva, Albena, Alexandrova, Elina, Tsvetanova, Almira, Georgieva, Miroslava, Stefanova, Daniela, Tsekova, Lyubomir, Vezenkov, Reni, Kalfin, Diamara, Uzunova, Polina, Petkova-Kirova   +10 more
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Neuroprotective effects of novel pyrrolidine-2-one derivatives on scopolamine-induced cognitive impairment in mice: Behavioral and biochemical analysis

Pharmacology Biochemistry and Behavior, 2023
Alzheimer's disease (AD) is a long-term neurodegenerative condition that impairs cognitive abilities. In brain acetylcholine deficit and oxidative stress may be considered the key pathogenic causes for AD, even though the basic etiology is still unknown.
Swati, Pant, Mohan, Gupta, Tulika, Anthwal, Monika, Chauhan, Sumitra, Nain   +4 more
openaire   +3 more sources

Ameliorative effects of amide derivatives of 1,3,4-thiadiazoles on scopolamine induced cognitive dysfunction

European Journal of Medicinal Chemistry, 2016
The present study reports the effect of amide derivatives of 1,3,4-thiadizoles on scopolamine induced deficit cholinergic neurotransmission and oxidative stress serving as promising leads for the therapeutics of cognitive dysfunction. Fourteen compounds (2c-8d) have been synthesised and evaluated against behavioural alterations using step down passive ...
Akanksha Kulshreshtha, Poonam Piplani
openaire   +3 more sources