Results 171 to 180 of about 1,353,799 (209)
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Validated capillary electrophoresis method for the determination of atropine and scopolamine derivatives in pharmaceutical formulations

Journal of Pharmaceutical and Biomedical Analysis, 1998
The simultaneous determination of atropine and scopolamine derivatives, which have similar structures, was investigated by using capillary zone electrophoresis. The effects of buffer pH, buffer concentration and hydroxypropyl-beta-cyclodextrin concentration on migration time and resolution of the investigated compounds were systematically studied.
Cherkaoui, Samir   +3 more
openaire   +4 more sources

Evaluation of the Memory Enhancement Effects of Aminopyrimidine Derivatives Using the Scopolamine Model of Dementia in Mice

Neurotoxicity Research
Aminopyrimidine compounds have been gaining traction in the field of drug discovery in recent years due to their emergence as multi-targeted molecules. This makes them perfect candidates as agents for cognitive improvement, as cognitive decline is a multifaceted condition.
Behnaz, Landi   +6 more
openaire   +3 more sources

Design and development of 1,3,4-oxadiazole derivatives as potential inhibitors of acetylcholinesterase to ameliorate scopolamine-induced cognitive dysfunctions

Bioorganic Chemistry, 2019
The novel hybrids bearing 4-aminopyridine (4-AP) tethered with substituted 1,3,4-oxadiazole nucleus were designed, synthesized, and evaluated for their potential AChE inhibitory property along with significant antioxidant potential. The inhibitory potential (IC50) of synthesized analogs was evaluated against human cholinesterases (hAChE and hBChE ...
Puja, Mishra   +8 more
openaire   +3 more sources

Colorimetric Determination of Atropine, Homatropine, Scopolamine, and Their Derivatives by the Ferric Hydroxamate Method

Journal of Pharmaceutical Sciences, 1970
The purpose of this study was to develop a procedure for the quantitative analysis of the salts of the solanaceous alkaloids in the presence of their hydrolysis products. The salts taken were atropine sulfate, homatropine hydrobromide, homatropine methyl-bromide, scopolamine hydrobromide, and scopolamine methyl-bromide. The ferric hydroxamate procedure
J A, Feldman, B J, Robb
openaire   +3 more sources

Antispasmodics. VIII. Scopolamine Derivatives

Journal of the American Chemical Society, 1956
Robert Bruce Moffett   +1 more
openaire   +2 more sources

Elucidating the oxidation mechanism of scopolamine derivatives via electrochemistry, UV–Vis, and NMR

Journal of Electroanalytical Chemistry
Cristian Vera   +7 more
openaire   +2 more sources

Neuroprotective Effect of Thiazolidine-2,4-dione Derivatives on Memory Deficits and Neuropathological Symptoms of Dementia on a Scopolamine-Induced Alzheimer's Model in Adult Male Wistar Rats.

ACS Chemical Neuroscience, 2023
Alzheimer's disease (AD) is a neurodegenerative disorder associated with a decline in memory deficits and neuropathological diagnosis with loss of cholinergic neurons in the brains of older adults.
Maryam Taheri   +3 more
semanticscholar   +1 more source

Water-soluble derivative of propolis mitigates scopolamine-induced learning and memory impairment in mice

Pharmacology Biochemistry and Behavior, 2008
The water-soluble derivative of propolis (WSDP) was prepared from fresh Chinese propolis. Its major constituents were identified by high performance liquid chromatography (HPLC) analysis. It has been reported that propolis possessed a broad spectrum of biological activities but including few studies on learning and memory by now.
Juan, Chen   +5 more
openaire   +2 more sources

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