Results 11 to 20 of about 1,353,799 (209)

The memory ameliorating effects of novel N-benzyl pyridine-2-one derivatives on scopolamine-induced cognitive deficits in mice [PDF]

Laboratory Animal Research
Background Alzheimer's disease (AD), the most common form of progressive dementia in the elderly, is a chronic neurological disorder that decreases cognitive ability.
Swati Pant, Mohan Gupta, Tulika Anthwal, Monika Chauhan, Sumitra Nain   +4 more
doaj   +5 more sources

Succinamide Derivatives Ameliorate Neuroinflammation and Oxidative Stress in Scopolamine-Induced Neurodegeneration [PDF]

Biomolecules, 2020
Oxidative stress-mediated neuroinflammatory events are the hallmark of neurodegenerative diseases. The current study aimed to synthesize a series of novel succinamide derivatives and to further investigate the neuroprotective potential of these compounds
Sumbal Iqbal, Fawad Ali Shah, Komal Naeem, Humaira Nadeem, Sadia Sarwar, Zaman Ashraf, Muhammad Imran, Tariq Khan, Tayyaba Anwar, Shupeng Li   +9 more
doaj   +4 more sources

Effect of sulfonamide derivatives of phenylglycine on scopolamine‐induced amnesia in rats

Ibrain, 2023
Alzheimer's disease is a neurodegenerative disease responsible for dementia and other neuropsychiatric symptoms. In the present study, compounds 30 and 33, developed earlier in our laboratory as selective butyrylcholinesterase inhibitors, were tested ...
Ankit Ganeshpurkar, Ravi Singh, Pratigya Tripathi, Qadir Alam, Sairam Krishnamurthy, Ashok Kumar, Sushil K. Singh   +6 more
doaj   +4 more sources

Vanillin derivatives as antiamnesic agents in scopolamine-induced memory impairment in mice

Heliyon
Amnesia is a major health problem prevalent in almost every part of the world specifically in old age peoples. Vanillin analogues have played an important role in the field medicines.
Qamar Gul, Nasiara Karim, Mohammad Shoaib, Muhammad Zahoor, Mehboob Ur Rahman, Hayat Bilal, Riaz Ullah, Amal Alotaibi   +7 more
doaj   +4 more sources

A Novel Probiotic Limosilactobacillus fermentum IOB802 and Its Postbiotic Alleviate Cognitive Impairment Induced by Scopolamine in Mice [PDF]

Foods
Cognitive impairment is acknowledged as an early stage between normal aging and Alzheimer’s disease, emphasizing the need for prompt intervention. There is growing evidence that the gut–brain axis plays a role in regulating cognitive function, indicating
Yuxuan Song, Wenjing Pan, Linlin Meng, Hengyu Wu, Boyang Li, Xuemei Han, Tianmin Fu, Wu Liang, Sa Zhou, Wenjian Ma   +9 more
doaj   +3 more sources

Flavonoid Derivatives as Potential Cholinesterase Inhibitors in Scopolamine-Induced Amnesic Mice: An In Vitro, In Vivo and Integrated Computational Approach

Brain Sciences, 2022
Flavonoids are one of the most exciting types of phenolic compounds with a wide range of bioactive benefits. A series of flavone derivatives (F1–F5) were previously synthesized from substituted O-hydroxy acetophenone and substituted chloro-benzaldehydes.
Fakhria A. Al-Joufi, Syed Wadood Ali Shah, Mohammad Shoaib, Mehreen Ghias, Shafiullah, Atif Ali Khan Khalil, Syed Babar Jamal, Syed Muhammad Hassan Shah, Muhammad Zahoor   +8 more
doaj   +4 more sources

The Ameliorating Effect of Phenylsulfonamide Derivatives on Scopolamine-Induced Memory Impairment in Mice via Inhibition of mPGES-1 [PDF]

Proceedings, 2019
Our previous research showed that a novel series of phenylsulfonyl hydrazide derivatives reduced LPS-induced PGE2 levels in RAW 264.7 macrophage cells via an inhibition of mPGES-1 enzyme. As a continuous work, new phenylsulfonamide derivatives (5a-5k) as
Ki Deok Ryu, Yoon Hyoung Moon, Do Hyeong Ko, Kyung-Tae Lee, Jae Yeol Lee   +4 more
doaj   +3 more sources

Bioorganic Chemistry, Toxinology, and Pharmaceutical Uses of Datura Metabolites and Derivatives [PDF]

Toxins
Datura species have been recognized for their potent pharmacological properties, producing a diverse array of tropane and non-tropane alkaloids with significant clinical and toxicological relevance.
Amin Mahmood Thawabteh, Saleh Sulaiman, Ilaf Omar Alabed, Laura Scrano, Donia Karaman, Rafik Karaman, Sabino A. Bufo   +6 more
doaj   +3 more sources

Neuroprotective Effect of Yucca schidigera Roezl ex Ortgies Bark Phenolic Fractions, Yuccaol B and Gloriosaol A on Scopolamine-Induced Memory Deficits in Zebrafish

Molecules, 2022
Y. schidigera contains a number of unusual polyphenols, derivatives of resveratrol and naringenin, called spiro-flavostilbenoids, which have potent in vitro anti-inflammatory, antioxidant, and moderate cholinesterase inhibitory activities. To date, these
Łukasz Pecio, Solomiia Kozachok, Ion Brinza, Razvan Stefan Boiangiu, Lucian Hritcu, Cornelia Mircea, Ana Flavia Burlec, Oana Cioanca, Monica Hancianu, Olga Wronikowska-Denysiuk, Krystyna Skalicka-Woźniak, Wiesław Oleszek   +11 more
doaj   +2 more sources

Anxiolytic, Promnesic, Anti-Acetylcholinesterase and Antioxidant Effects of Cotinine and 6-Hydroxy-L-Nicotine in Scopolamine-Induced Zebrafish (Danio rerio) Model of Alzheimer’s Disease

Antioxidants, 2021
Cotinine (COT) and 6-hydroxy-L-nicotine (6HLN) are two nicotinic derivatives that possess cognitive-improving abilities and antioxidant properties in different rodent models of Alzheimer’s disease (AD), eluding the side-effects of nicotine (NIC), the ...
Razvan Stefan Boiangiu, Marius Mihasan, Dragos Lucian Gorgan, Bogdan Alexandru Stache, Lucian Hritcu   +4 more
doaj   +2 more sources