Results 11 to 20 of about 291,183 (179)

Antiamnesic Effects of Novel Phthalimide Derivatives in Scopolamine-Induced Memory Impairment in Mice: A Useful Therapy for Alzheimer’s Disease [PDF]

ACS Omega, 2023
Phthalimides have diverse bioactivities and are attractive molecules for drug discovery and development. Here, we explored new synthesized phthalimide derivatives (compounds 1-3) in improving memory impairment associated with Alzheimer's disease (AD), using in vitro and ex vivo acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibition ...
Nasiara Karim, Inbisat Khan, Imran Khan, Sobia Ahsan Halim, Asaad Khalid, Ashraf N. Abdalla, Najeeb Ur Rehman, Ajmal Khan, Ahmed Al‐Harrasi   +8 more
openalex   +3 more sources

Enhanced Cognitive Effects of Demethoxycurcumin, a Natural Derivative of Curcumin on Scopolamine-Induced Memory Impairment in Mice [PDF]

Molecules, 2016
In the present study, we examined the ameliorating effects of demethoxycurcumin (DMC) on memory impairment induced by scopolamine using passive avoidance and Morris water maze tests in mice. Moreover, to determine the neurobiological effects underlying the ameliorating effects of the DMC, choline acetyltransferase (ChAT) immunoreactivity was evaluated ...
Dong Hui Lim, Hyun Ho Son, Min Young Um, In Ho Kim, Daeseok Han, Suengmok Cho, Changho Lee   +6 more
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Synthesis and evaluation of enzyme inhibitory potential of some derivatives of scopolamine

Turkish Journal of Chemistry, 2012
Durre Shahwar, Muhammad Asam Raza, TANIA KHAN   +2 more
openalex   +3 more sources

Effects of Paeoniflorin Derivatives on Scopolamine-Induced Amnesia Using a Passive Avoidance Task in Mice; Structure-Activity Relationship.

Biological and Pharmaceutical Bulletin, 1998
Paeoniflorin (1) and its derivatives having in common a cage-like pinane skeleton with hemiketal-acetal system, were evaluated for their effects on memory impairment induced by scopolamine in mice using a step-down type passive avoidance task. In the test session, 1 and its derivatives were intraperitoneally (i.p.) administered at doses of 0.002, 0.01,
A. A. ABDEL‐HAFEZ, Meselhy R. Meselhy, Norio Nakamura, Masao HATTORI, Hiroshi Watanabe, Yukihisa MUKARAMI, M. A. EL‐GENDY, Nadia M. Mahfouz, Tarek A. Mohamed   +8 more
openalex   +5 more sources

Ameliorative Effects of Azaindolizinone Derivative ZSET845 on Scopolamine-Induced Deficits in Passive Avoidance and Radial-Arm Maze Learning in the Rat

Japanese Journal of Pharmacology, 2001
Effects of ZSET845 (3,3-dibenzylimidazo[1,2-a]pyridin-2-(3H)-one), a newly synthesized cognitive enhancer, and donepezil and tacrine on the scopolamine-induced cognitive deficits in rats were examined in passive avoidance and radial-arm maze tasks. ZSET845 (0.01 mg/kg) showed a greater ameliorative effect than donepezil (0.1 mg/kg) or tacrine (1 mg/kg)
Yoshimasa Yamaguchi, Masaya Higashi, Toshiyuki Matsuno, Seiichiro Kawashima   +3 more
openalex   +5 more sources

Thermal (In)stability of Atropine and Scopolamine in the GC-MS Inlet

Toxics, 2021
The intoxication due to unintentional or intentional ingestion of plant material containing tropane alkaloids is quite frequent. GC-MS method is still widely used for the identification of these toxicologically important substances in human specimen ...
Gordana Koželj, Helena Prosen
doaj   +1 more source

Neuroprotective Effect of Yucca schidigera Roezl ex Ortgies Bark Phenolic Fractions, Yuccaol B and Gloriosaol A on Scopolamine-Induced Memory Deficits in Zebrafish

Molecules, 2022
Y. schidigera contains a number of unusual polyphenols, derivatives of resveratrol and naringenin, called spiro-flavostilbenoids, which have potent in vitro anti-inflammatory, antioxidant, and moderate cholinesterase inhibitory activities. To date, these
Łukasz Pecio, Solomiia Kozachok, Ion Brinza, Razvan Stefan Boiangiu, Lucian Hritcu, Cornelia Mircea, Ana Flavia Burlec, Oana Cioanca, Monica Hancianu, Olga Wronikowska-Denysiuk, Krystyna Skalicka-Woźniak, Wiesław Oleszek   +11 more
doaj   +1 more source

Investigation of Antistress and Antidepressant Activities of Synthetic Curcumin Analogues: Behavioral and Biomarker Approach

Biomedicines, 2022
Depression is a serious psychiatric disorder that affects millions of individuals all over the world, thus demanding special attention from researchers in order to investigate its effective remedies.
Haya Hussain, Shujaat Ahmad, Syed Wadood Ali Shah, Abid Ullah, Mazen Almehmadi, Osama Abdulaziz, Mamdouh Allahyani, Ahad Amer Alsaiari, Mustafa Halawi, Edrous Alamer   +9 more
doaj   +1 more source

Discovery of Novel Tryptanthrin Derivatives with Benzenesulfonamide Substituents as Multi-Target-Directed Ligands for the Treatment of Alzheimer’s Disease

Pharmaceuticals, 2023
Based on the multi-target-directed ligands (MTDLs) approach, two series of tryptanthrin derivatives with benzenesulfonamide substituents were evaluated as multifunctional agents for the treatment of Alzheimer’s disease (AD).
Guoxing Wang, Jiyu Du, Jie Ma, Peipei Liu, Siqi Xing, Jucheng Xia, Shuanghong Dong, Zeng Li   +7 more
doaj   +1 more source

Oral Administration of Egg- and Soy-Derived Lysophosphatidylcholine Mitigated Acetylcholine Depletion in the Brain of Scopolamine-Treated Rats

Nutrients, 2023
Enzyme-modified lecithin that contains lysophosphatidylcholine (LPC) is generally recognized as safe. However, its potential as a functional ingredient has been less investigated than other choline (Ch)-containing compounds, such as glycerophosphocholine (GPC).
Ryohei Tanaka-Kanegae, Hiroyuki Kimura, Koichiro Hamada   +2 more
openaire   +2 more sources