Results 21 to 30 of about 291,183 (179)

New Myrtenal–Adamantane Conjugates Alleviate Alzheimer’s-Type Dementia in Rat Model

Molecules, 2022
Alzheimer’s disease (AD) is a neurodegenerative disease associated with memory impairment and other central nervous system (CNS) symptoms. Two myrtenal–adamantane conjugates (MACs) showed excellent CNS potential against Alzheimer’s models.
Stela Dragomanova, Maria Lazarova, Aldar Munkuev, Evgeniy Suslov, Konstantin Volcho, Nariman Salakhutdinov, Amina Bibi, Jóhannes Reynisson, Elina Tzvetanova, Albena Alexandrova, Almira Georgieva, Diamara Uzunova, Miroslava Stefanova, Reni Kalfin, Lyubka Tancheva   +14 more
doaj   +1 more source

Discovery of benzamide-hydroxypyridinone hybrids as potent multi-targeting agents for the treatment of Alzheimer's disease

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
A novel class of benzamide-hydroxypyridinone (HPO) derivatives were innovatively designed, synthesised, and biologically evaluated as potential multitargeting candidates for the treatment of Alzheimer's disease (AD) through pharmacophores-merged ...
Xiaoying Jiang, Jianan Guo, Changjun Zhang, Jinping Gu, Tao Zhou, Renren Bai, Yuanyuan Xie   +6 more
doaj   +1 more source

Anxiolytic, Promnesic, Anti-Acetylcholinesterase and Antioxidant Effects of Cotinine and 6-Hydroxy-L-Nicotine in Scopolamine-Induced Zebrafish (Danio rerio) Model of Alzheimer’s Disease

Antioxidants, 2021
Cotinine (COT) and 6-hydroxy-L-nicotine (6HLN) are two nicotinic derivatives that possess cognitive-improving abilities and antioxidant properties in different rodent models of Alzheimer’s disease (AD), eluding the side-effects of nicotine (NIC), the ...
Razvan Stefan Boiangiu, Marius Mihasan, Dragos Lucian Gorgan, Bogdan Alexandru Stache, Lucian Hritcu   +4 more
doaj   +1 more source

Fractal derivatives, fractional derivatives and $q$-deformed calculus [PDF]

Entropy 2023, 25(7), 1008, 2023
This work presents an analysis of fractional derivatives and fractal derivatives, discussing their differences and similarities. The fractal derivative is closely connected to Haussdorff's concepts of fractional dimension geometry. The paper distinguishes between the derivative of a function on a fractal domain and the derivative of a fractal function,
arxiv   +1 more source

Characterization and Exploration of the Neuroprotective Potential of Oat-Protein-Derived Peptides in PC12 Cells and Scopolamine-Treated Zebrafish

Nutrients, 2023
Neurodegenerative disorders pose a substantial risk to human health, and oxidative stress, cholinergic dysfunction, and inflammation are the major contributors. The purpose of this study was to explore the neuroprotective effects of oat protein hydrolysate (OPH) and identify peptides with neuroprotective potential.
Hamad Rafique, Xinzhong Hu, Tian Ren, Rui Dong, Rana Muhammad Aadil, Liang Zou, Mian Kamran Sharif, Lu Li   +7 more
openaire   +2 more sources

Activity-Dependent Brain-Derived Neurotrophic Factor Release Is Required for the Rapid Antidepressant Actions of Scopolamine [PDF]

Biological Psychiatry, 2018
Brain-derived neurotrophic factor (BDNF) plays a key role in the pathophysiology and treatment of depression. Recent clinical studies demonstrate that scopolamine, a nonselective muscarinic acetylcholine receptor antagonist, produces rapid antidepressant effects in patients with depression.
Sriparna Ghosal, Matthew J. Girgenti, Ashley E. Lepack, Eunyoung Bang, Wenzhu Yue, Ronald S. Duman, Brendan D. Hare   +6 more
openaire   +3 more sources

Development of naringenin-O-alkylamine derivatives as multifunctional agents for the treatment of Alzheimer’s disease

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
In this study, a series of naringenin-O-alkylamine derivatives were designed and obtained by introducing an alkylamine fragment into the naringenin skeleton.
Jing Yang, Yi Zhou, Yujuan Ban, Jing Mi, Ying He, Xinjuan Li, Zhengwei Liu, Keren Wang, Gaofeng Zhu, Wenmin Liu, Zhenghuai Tan, Zhipei Sang   +11 more
doaj   +1 more source

Supra and subgingival application of antiseptics or antibiotics during periodontal therapy

Periodontology 2000, EarlyView., 2023
Abstract Periodontal diseases (gingivitis and periodontitis) are characterized by inflammatory processes which arise as a result of disruption of the balance in the oral ecosystem. According to the current S3 level clinical practice guidelines, therapy of patients with periodontitis involves a stepwise approach that includes the control of the patient ...
Elena Figuero, Jorge Serrano, Nicole Birgit Arweiler, Thorsten Mathias Auschill, Ali Gürkan, Gülnur Emingil   +5 more
wiley   +1 more source

Design, synthesis, in vitro and in vivo evaluation of benzylpiperidine-linked 1,3-dimethylbenzimidazolinones as cholinesterase inhibitors against Alzheimer’s disease

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
Cholinesterase inhibitor plays an important role in the treatment of patients with Alzheimer’s disease (AD). Herein, we report the medicinal chemistry efforts leading to a new series of 1,3-dimethylbenzimidazolinone derivatives.
Jun Mo, Tingkai Chen, Hongyu Yang, Yan Guo, Qi Li, Yuting Qiao, Hongzhi Lin, Feng Feng, Wenyuan Liu, Yao Chen, Zongliang Liu, Haopeng Sun   +11 more
doaj   +1 more source

No Nonlocality. No Fractional Derivative [PDF]

Communications in Nonlinear Science and Numerical Simulation. 2018. Vol.62. P.157-163, 2018
The paper discusses the characteristic properties of fractional derivatives of non-integer order. It is known that derivatives of integer orders are determined by properties of differentiable functions only in an infinitely small neighborhood of the considered point.
arxiv   +1 more source