Results 41 to 50 of about 1,353,799 (209)

Enhanced Cognitive Effects of Demethoxycurcumin, a Natural Derivative of Curcumin on Scopolamine-Induced Memory Impairment in Mice [PDF]

Molecules, 2016
In the present study, we examined the ameliorating effects of demethoxycurcumin (DMC) on memory impairment induced by scopolamine using passive avoidance and Morris water maze tests in mice. Moreover, to determine the neurobiological effects underlying the ameliorating effects of the DMC, choline acetyltransferase (ChAT) immunoreactivity was evaluated ...
Dong Wook Lim, Hyun Jung Son, Min Young Um, In-Ho Kim, Daeseok Han, Suengmok Cho, Chang-Ho Lee   +6 more
openaire   +3 more sources

Analysis of scopolamine and its related substances by means of high-performance liquid chromatography

Acta Chromatographica, 2022
The retention behaviour of scopolamine (hyoscine) and its related compounds (norhyoscine, atropine, homatropine, and noratropine) was investigated on the silica-based HPLC stationary phase.
D. Obradović, Ivana Pešić, M. Čarapić, S. Lazović, D. Agbaba   +4 more
semanticscholar   +1 more source

Preparation of 4-Flexible Amino-2-Arylethenyl-Quinoline Derivatives as Multi-Target Agents for the Treatment of Alzheimer’s Disease

Molecules, 2018
Alzheimer’s disease (AD) is a complex and multifactorial neurodegenerative disorder of aged people. The development of multitarget-directed ligands (MTDLs) to act as multifunctional agents to treat this disease is the mainstream of current research.
Xiao-Qin Wang, Chu-Ping Zhao, Long-Cheng Zhong, De-Ling Zhu, De-Hao Mai, Mei-Gui Liang, Ming-Hua He   +6 more
doaj   +1 more source

Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden [PDF]

, 2010
Background It has traditionally been thought that the pathological accumulation of tau in Alzheimer's disease and other tauopathies facilitates neurodegeneration, which in turn leads to cognitive impairment.
A de Calignon, AD Mosnaim, Amelia G Johnson, B Reisberg, B Zhang, CA Dickey, CA Dickey, Chad A Dickey, Clara Kraft, Edwin J Weeber, EM Sigurdsson, Erin E Congdon, F van Bebber, HM Hassan, I Walter-Sack, J Lewis, Jason E Gestwicki, Jeffrey R Jones, John C O'Leary, John Koren, Jose F Abisambra, K Santacruz, Karen E Duff, Laura J Blair, M Necula, M Oz, Melinda Peters, MJ West, ML Smith, MP Mazanetz, Paul Marinec, Qingyou Li, RS Doody, S Deiana, S Taniguchi, TL Spires-Jones, TM Visarius, UK Jinwal, Umesh K Jinwal   +38 more
core   +6 more sources

Effect of Sanguisorba minor on scopolamine-induced memory loss in rat: involvement of oxidative stress and acetylcholinesterase

Metabolic brain disease, 2021
Sanguisorba minor (S. minor) has neuroprotective and antioxidant activities. However, its potential benefits in ameliorating learning and memory functions have been explored in no studies up to now.
Z. Hosseini, Fatemeh Mansouritorghabeh, Faezeh Sadat Hosseini Kakhki, M. Hosseini, H. Rakhshandeh, A. Hosseini, Maede Hasanpour, M. Iranshahi, Arezoo Rajabian   +8 more
semanticscholar   +1 more source

The site of emetic action of veratrum derivatives. [PDF]

, 1951
Thesis (M.A.)--Boston ...
Swiss, Edward D
core   +1 more source

Nitric Oxide-Dependent Mechanisms Underlying MK-801- or Scopolamine-Induced Memory Dysfunction in Animals: Mechanistic Studies

International Journal of Molecular Sciences, 2021
MK-801, an NMDA receptor antagonist, and scopolamine, a cholinergic receptor blocker, are widely used as tool compounds to induce learning and memory deficits in animal models to study schizophrenia or Alzheimer-type dementia (AD), respectively.
P. Cieślik, Anna Siekierzycka, A. Radulska, Agata Płoska, G. Burnat, P. Brański, L. Kalinowski, J. Wierońska   +7 more
semanticscholar   +1 more source

Ketamine: NMDA receptors and beyond [PDF]

, 2016
Human studies examining the effects of the dissociative anesthetic ketamine as a model for psychosis and as a rapidly acting antidepressant have spurred great interest in understanding ketamine's actions at molecular, cellular, and network levels ...
Izumi, Yukitoshi, Mennerick, Steven, Zorumski, Charles F   +2 more
core   +2 more sources

Clinical pharmacology and prescribing education: An updated medical school curriculum from the British Pharmacological Society

British Journal of Clinical Pharmacology, EarlyView.
Aims Prescribing is a complex, essential skill that doctors must acquire to practice medicine safely and effectively. The British Pharmacological Society has historically provided a core curriculum to guide clinical pharmacology and prescribing education in UK medical schools.
Dagan O. Lonsdale, Clare Guilding, Jennifer Koenig, Michael Okorie, Reecha Sofat, Simon Maxwell   +5 more
wiley   +1 more source

Molecular pharmacology of rosmarinic and salvianolic acids: Potential seeds for Alzheimer’s and vascular dementia drugs. [PDF]

, 2018
Both caffeic acid and 3,4-dihydroxyphenyllactic acid (danshensu) are synthesized through two distinct routs of the shikimic acid biosynthesis pathway. In many plants, especially the rosemary and sage family of Lamiaceae, these two compounds are joined ...
Bose, Chen, Gu, Haas, Habtemariam, Habtemariam, Habtemariam, Jha, Juan-Badaturugea, Moosavi, Riemens, Scarpati, Solomon Habtemariam, Tang, Wang, Zhu   +15 more
core   +2 more sources