Results 61 to 70 of about 3,294 (199)

Development of Multifunctional Pyrimidinylthiourea Derivatives as Potential Anti-Alzheimer Agents

, 2016
Starting from a screening-hit compound, via structure modifications and optimizations, a series of nonfused and nonassembly pyrimidinylthiourea derivatives (2–5) was designed, synthesized, and evaluated as novel multifunctional agents against Alzheimer ...
Xiaokang Li (158714), Xinyu Zheng (453019), Yan Fu (110146), Fei Mao (7777), Jian Li (41607), Zhengyu Lu (3104262), Wei Ni (286780), Huan Wang (109286), Haiyan Zhang (176919), Fulin Lian (1714375), Jin Zhu (164147), Naixia Zhang (474251)   +11 more
core   +1 more source

Branch retinal artery occlusion due to patent foramen ovale in a teenager

Experimental Physiology, EarlyView.
Abstract This report demonstrates the diagnostic evaluation and clinical management of a 16‐year‐old girl who developed branch retinal artery occlusion secondary to patent foramen ovale. The goal is to increase awareness of this rare presentation in adolescents among clinicians, with a summary of the important clinical features, multimodal imaging ...
Jie Zu, Fang Fan, Jiayao Wang, Jianmin Wang, Zhiyang Jia   +4 more
wiley   +1 more source

Effects of Paeoniflorin Derivatives on Scopolamine-Induced Amnesia Using a Passive Avoidance Task in Mice; Structure-Activity Relationship.

Biological and Pharmaceutical Bulletin, 1998
Paeoniflorin (1) and its derivatives having in common a cage-like pinane skeleton with hemiketal-acetal system, were evaluated for their effects on memory impairment induced by scopolamine in mice using a step-down type passive avoidance task. In the test session, 1 and its derivatives were intraperitoneally (i.p.) administered at doses of 0.002, 0.01,
ABDEL-HAFEZ, Atef A., MESELHY, Meselhy R., NAKAMURA, Norio, HATTORI, Masao, WATANABE, Hiroshi, MUKARAMI, Yukihisa, EL-GENDY, Mahmoud A., MAHFOUZ, Nadia M., MOHAMED, Tarek A.   +8 more
openaire   +3 more sources

Preferences of Pediatric Patients and Their Caregivers for Chemotherapy‐Induced Nausea and Vomiting Control Endpoints: A Mixed Methods Study

Pediatric Blood &Cancer, Volume 73, Issue 7, July 2026.
ABSTRACT Purpose Although not always achieved, complete chemotherapy‐induced nausea and vomiting (CINV) control is the conventional goal of CINV prophylaxis. In this two‐center, mixed‐methods study, we sought to understand the preferences of adolescent patients and family caregivers for CINV control endpoints.
Haley Newman, Tadi Hondonga, Alison Berry, Caitlin Elgarten, Jason Freedman, Katelyn Oranges, Sara McDonough, Caroline Diorio, L. Lee Dupuis   +8 more
wiley   +1 more source

Behavioral and Biochemical Effects of an Arylhydrazone Derivative of 5-Methoxyindole-2-Carboxylic Acid in a Scopolamine-Induced Model of Alzheimer’s Type Dementia in Rats

Molecules
Alzheimer’s disease (AD) has long proven to be a complex neurodegenerative disorder, with cholinergic dysfunction, oxidative stress, and neuroinflammation being just a few of its pathological features.
Polina Petkova-Kirova, Neda Anastassova, Borislav Minchev, Diamara Uzunova, Valya Grigorova, Elina Tsvetanova, Almira Georgieva, Albena Alexandrova, Miroslava Stefanova, Denitsa Yancheva, Reni Kalfin, Lyubka Tancheva   +11 more
doaj   +1 more source

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, Volume 46, Issue 4, Page 1173-1229, July 2026.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Brain-derived neurotrophic factor modulation in response to oxidative stress and corticosterone: role of scopolamine and mirtazapine

Life Sciences
Major Depressive Disorder (MDD) is a very complex disease, challenging to study and manage. The complexities of MDD require extensive research of its mechanisms to develop more effective therapeutic approaches. Crucial in the context of this disease is the role of brain-derived neurotrophic factor (BDNF) signaling pathway.This manuscript aims to ...
Correia, Ana Salomé, Torrado, Marília, Costa-Coelho, Tiago, Carvalho, Eva Daniela, Inteiro-Oliveira, Sara, Diógenes, Maria José, Pêgo, Ana Paula, Santos, Sofia Duque, Sebastião, Ana M, Vale, Nuno   +9 more
openaire   +3 more sources

BIOLOGICAL EVALUATION OF SCHIFF BASES OF NEW ISATIN DERIVATIVES FOR ANTI ALZHEIMER\u27S ACTIVITY

, 2014
Isatin can be used for synthesis of many heterocyclic compounds having diverse pharmacological activities. Several Isatin derivatives are being developed as promising drugs in the area of central nervous system diseases.
Rao. J, Venkateshwar, Mohan.P, Chandra
core  

Attenuation of neurological deficit by a novel ethanolamine derivative in rats after brain trauma

Journal of Experimental Pharmacology, 2019
Yuriy Igorevich Sysoev,1,2 Bright Chukwunwike Uzuegbunam,1 Sergey Vladimirovich Okovityi11Department of Pharmacology and Clinical Pharmacology, Saint-Petersburg State Chemical-Pharmaceutical University, St. Petersburg, Russia; 2Institute of Translational
Sysoev YI, Uzuegbunam BC, Okovityi SV
doaj  

Preclinical models for evaluating psychedelics in the treatment of major depressive disorder

British Journal of Pharmacology, Volume 183, Issue 14, Page 3970-3991, July 2026.
Psychedelic drugs have seen a resurgence in interest as a next generation of psychiatric medicines with potential as rapid‐acting antidepressants (RAADs). Despite promising early clinical trials, the mechanisms which underlie the effects of psychedelics are poorly understood.
Laith Alexander, Dasha Anderson, Luke Baxter, Matthew Claydon, James Rucker, Emma S. J. Robinson   +5 more
wiley   +1 more source