Results 61 to 70 of about 627,170 (198)

Knocking Out Two Polyphenol Oxidase Genes Significantly Improves Recombinant Protein Purification in Nicotiana benthamiana

Plant Biotechnology Journal, EarlyView.
ABSTRACT Efficient purification remains a key technical challenge affecting the recovery efficiency of recombinant proteins in plant‐based systems. Complex metabolites, particularly polyphenols, often cause recombinant protein aggregation during purification.
Hai‐Ping Diao, Hui‐Xin Meng, Xue‐Jiao Xu, Zeng‐Lin Zhang, Jian‐Feng Zhang, Yong‐Feng Guo, Inhwan Hwang, Shi‐Jian Song   +7 more
wiley   +1 more source

BIOLOGICAL EVALUATION OF SCHIFF BASES OF NEW ISATIN DERIVATIVES FOR ANTI ALZHEIMER\u27S ACTIVITY [PDF]

, 2014
Isatin can be used for synthesis of many heterocyclic compounds having diverse pharmacological activities. Several Isatin derivatives are being developed as promising drugs in the area of central nervous system diseases.
Rao. J, Venkateshwar, Mohan.P, Chandra
core   +1 more source

Tonoplast‐Localized ABCC Transporters Enhance Heterologous Production of the Antidiabetic Montbretin A and Its Analogues in Nicotiana benthamiana

Plant Biotechnology Journal, EarlyView.
ABSTRACT The plant‐derived specialized metabolite montbretin A (MbA) is under development as an improved treatment for Type 2 diabetes, a worldwide epidemic. MbA is an acylated flavonol glycoside so far only found in small amounts in montbretia (Crocosmia × crocosmiiflora) corms.
Charlotte Hijmans, Filipe Cabrita Cruz, Lars H. Kruse, Joerg Bohlmann, Sandra Irmisch   +4 more
wiley   +1 more source

Effects of Paeoniflorin Derivatives on Scopolamine-Induced Amnesia Using a Passive Avoidance Task in Mice; Structure-Activity Relationship.

Biological and Pharmaceutical Bulletin, 1998
Paeoniflorin (1) and its derivatives having in common a cage-like pinane skeleton with hemiketal-acetal system, were evaluated for their effects on memory impairment induced by scopolamine in mice using a step-down type passive avoidance task. In the test session, 1 and its derivatives were intraperitoneally (i.p.) administered at doses of 0.002, 0.01,
ABDEL-HAFEZ, Atef A., MESELHY, Meselhy R., NAKAMURA, Norio, HATTORI, Masao, WATANABE, Hiroshi, MUKARAMI, Yukihisa, EL-GENDY, Mahmoud A., MAHFOUZ, Nadia M., MOHAMED, Tarek A.   +8 more
openaire   +3 more sources

Effects of Vitexin on Scopolamine-Induced Memory Impairment in Rats [PDF]

, 2013
Various synthetic derivatives of natural flavonoids are known to have neuroactive properties. The present study aimed to investigate the effects of vitexin (5, 7, 4-trihydroxyflavone-8-glucoside), a flavonoid found in such plants as tartary buckwheat ...
Shafiee, Mahsa, Sheikhi, Mehdi, Abbasi, Esmail, Nassiri-Asl, Marjan   +3 more
core  

Wind Derivatives: Modeling and Pricing [PDF]

, 2013
Wind is considered to be a free, renewable and environmentally friendly source of energy. However, wind farms are exposed to excessive weather risk since the power production depends on the wind speed, the wind direction and the wind duration.
Zapranis, Achilleas, Alexandridis, Antonis   +1 more
core   +1 more source

Time to Confirmed Completion of Bowel Preparation as a Preprocedural Indicator of Colonoscope Insertion Difficulty: A Prospective Observational Study

DEN Open, Volume 7, Issue 1, April 2027.
ABSTRACT Background and Aims Runway time, defined as the interval between completion of polyethylene glycol ingestion and the start of colonoscopy, has been studied as a determinant of bowel cleansing quality. However, whether the bowel preparation course itself is associated with colonoscope insertion difficulty remains unclear.
Kazuki Horiuchi, Yusuke Ishibashi, Hiroki Ueda   +2 more
wiley   +1 more source

Behavioral and Biochemical Effects of an Arylhydrazone Derivative of 5-Methoxyindole-2-Carboxylic Acid in a Scopolamine-Induced Model of Alzheimer’s Type Dementia in Rats

Molecules
Alzheimer’s disease (AD) has long proven to be a complex neurodegenerative disorder, with cholinergic dysfunction, oxidative stress, and neuroinflammation being just a few of its pathological features.
Polina Petkova-Kirova, Neda Anastassova, Borislav Minchev, Diamara Uzunova, Valya Grigorova, Elina Tsvetanova, Almira Georgieva, Albena Alexandrova, Miroslava Stefanova, Denitsa Yancheva, Reni Kalfin, Lyubka Tancheva   +11 more
doaj   +1 more source

Feasibility and Safety Profile of Non‐anesthesiologist‐administered Propofol During Colorectal Endoscopic Submucosal Dissection: A Single‐center Study of 454 Procedures

DEN Open, Volume 7, Issue 1, April 2027.
ABSTRACT Objectives Studies of non‐anesthesiologist‐administered propofol (NAAP) during colorectal endoscopic submucosal dissection (ESD) are scarce, particularly in the elderly. We evaluated its feasibility across a broad age range and identified factors associated with sedation‐related adverse events.
Yumi Kishi, Mayo Tanabe, Naoyuki Uragami, Daijiro Shiomi, Mai Fukuda, Miho Kurahashi, Toshiki Hanzawa, Michimasa Yamaguchi, Mikio Muraoka, Hatsuka Nakamura, Rei Miyake, Yukiko Okada, Yoichi Toyoda, Akiko Toshimori, Takayoshi Ito, Noboru Yokoyama, Haruhiro Inoue   +16 more
wiley   +1 more source

Brain-derived neurotrophic factor modulation in response to oxidative stress and corticosterone: role of scopolamine and mirtazapine

Life Sciences
Major Depressive Disorder (MDD) is a very complex disease, challenging to study and manage. The complexities of MDD require extensive research of its mechanisms to develop more effective therapeutic approaches. Crucial in the context of this disease is the role of brain-derived neurotrophic factor (BDNF) signaling pathway.This manuscript aims to ...
Correia, Ana Salomé, Torrado, Marília, Costa-Coelho, Tiago, Carvalho, Eva Daniela, Inteiro-Oliveira, Sara, Diógenes, Maria José, Pêgo, Ana Paula, Santos, Sofia Duque, Sebastião, Ana M, Vale, Nuno   +9 more
openaire   +3 more sources