Results 71 to 80 of about 3,294 (199)

Redirecting Alzheimer's disease therapeutics: Multitarget drugs and complementary non‐pharmacological strategies

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder driven by intersecting pathological processes. Persistent attrition in AD drug‐development pipelines highlights the limited clinical impact of single‐target therapies and has increased interest in multi‐target approaches acting on shared biological hubs.
Humberto Martínez‐Orozco, Jesús Andrade‐Guerrero, Nelly Jovana Pastén‐Castrejón, Chryslaine Rodríguez‐Tanty, Sofía Y Diaz‐Miranda   +4 more
wiley   +1 more source

Additional file 1 of The memory ameliorating effects of novel N-benzyl pyridine-2-one derivatives on scopolamine-induced cognitive deficits in mice

Additional file 1: Graphical abstract. Figure S1. Comparing compounds 28 and 28a-e to the groups of mice given scopolamine, the compounds showed different effects on swim speed (a), escape latency (b), platform crossing time (c), and TSTQ (d). Values are
Mohan Gupta (13194486), Sumitra Nain (18139882), Tulika Anthwal (17913709), Swati Pant (17913703), Monika Chauhan (4780251)   +4 more
core   +1 more source

Metabolomics analysis of differential metabolites in the fruit pulp of‘Tubtim Siam Red Ruby Pummelo'(Citrus grandis)

Guoshu xuebao
【Objective】Tubtim Siam Red Ruby Pummelo originated from a Thailand's southern city, and fruit flesh was ruby-like, so it got the name for granted. It is currently one of the major cultivars of excellent pummelo in southern China. It is mainly eaten fresh,
LIU Chenglang, YANG Fan, ZHOU Xianyan, GAO Junyan, ZHAO Dongxing, GU Jinlou, WANG Shaohua, GUO Lina, BI Guanglin, ZHAO Aiqiu, YUE Jianqiang, DONG Meichao   +11 more
doaj   +1 more source

Clinical pharmacology and prescribing education: An updated medical school curriculum from the British Pharmacological Society

British Journal of Clinical Pharmacology, Volume 92, Issue 6, Page 1787-1808, June 2026.
Aims Prescribing is a complex, essential skill that doctors must acquire to practice medicine safely and effectively. The British Pharmacological Society has historically provided a core curriculum to guide clinical pharmacology and prescribing education in UK medical schools.
Dagan O. Lonsdale, Clare Guilding, Jennifer Koenig, Michael Okorie, Reecha Sofat, Simon Maxwell   +5 more
wiley   +1 more source

Korean Red Ginseng Attenuates Dysfunctions and Modulates Inflammatory and Neuroplasticity Markers in the Harmaline‐Induced Model of Essential Tremor

Brain and Behavior, Volume 16, Issue 6, June 2026.
Korean red Ginseng significantly reduces tremor severity, improves motor coordination, and ameliorates anxiety and cognitive deficits in a mouse model of essential tremor through suppression of neuroinflammatory markers and normalization of neuroplasticity genes in the cerebellum.
Monavareh Soti, Mehran Ilaghi, Leila Bagherzadeh, Fatemeh Shahsavari, Kristi A. Kohlmeier, Zeynab Pirmoradi, Mohammad Shabani   +6 more
wiley   +1 more source

Ameliorative Effects of Azaindolizinone Derivative ZSET845 on Scopolamine-Induced Deficits in Passive Avoidance and Radial-Arm Maze Learning in the Rat

Japanese Journal of Pharmacology, 2001
Effects of ZSET845 (3,3-dibenzylimidazo[1,2-a]pyridin-2-(3H)-one), a newly synthesized cognitive enhancer, and donepezil and tacrine on the scopolamine-induced cognitive deficits in rats were examined in passive avoidance and radial-arm maze tasks. ZSET845 (0.01 mg/kg) showed a greater ameliorative effect than donepezil (0.1 mg/kg) or tacrine (1 mg/kg)
Yamaguchi, Yoshimasa, Higashi, Masaya, Matsuno, Toshiyuki, Kawashima, Seiichiro   +3 more
openaire   +3 more sources

Anti‐Obesity Pharmacotherapy and Emerging Multimodal Interventions for Obstructive Sleep Apnea

Chronic Diseases and Translational Medicine, Volume 12, Issue 2, Page 100-112, June 2026.
Cellular and molecular mechanisms of obesity‐related obstructive sleep apnea (OSA). ADMA: asymmetric dimethyrarginine, NLRP3: nucleotide‐binding domain, leucine‐rich repeat family, Pyrin domain containing 3, TLR: toll‐like receptors, IL‐1β: interleukin‐1β, IL‐6: interleukin‐6; LPS: lipopolysacharide, ROS: reactive oxygen species, TNF‐α.
Anish Preshy, Cornelius J. Fernandez, Mohammad Hamid Nedai, Joseph M. Pappachan   +3 more
wiley   +1 more source

Standardized Pipeline for Metabolism and Cognition in GO‐DS21 Mouse Model: Investigating Down Syndrome Comorbidities

Current Protocols, Volume 6, Issue 6, June 2026.
Abstract Down syndrome (DS) is the most prevalent form of intellectual disability (ID) globally, with an incidence rate of approximately 1 in 1000 births, affecting over 5 million individuals worldwide. DS is characterized by a genetic profile that predisposes individuals to a range of medical and cognitive conditions, including ID and obesity, which ...
Mohammed Selloum, Patricia da Silva‐Buttkus, Fabrice Riet, Nathalia R. V. Dragano, Lillian Garrett, Hugues Jacobs, Sabine M. Hölter, Nicolas Torquet, Birgit Rathkolb, Loic Lindner, Valerie Gailus‐Durner, Guillaume Pavlovic, Li Chan, Johannes Beckers, Benoit Petit Demoulière, Helmut Fuchs, Elodie Ey, Tania Sorg, Martin Hrabe de Angelis, Yann Herault, the GO‐DS21 Consortium   +20 more
wiley   +1 more source

Molecular mechanism study on the contribution of open-fire flue-curing technology to tobacco leaf aroma

Chemical and Biological Technologies in Agriculture
This study compared the effects of open-fire flue-curing and conventional curing methods on the aroma and chemical composition of K326 tobacco leaves, aiming to reveal the molecular mechanisms of aroma formation during open-fire flue-curing.
Kaiyuan Gu, Jialiang Li, Lu Zhao, Jiaen Su, Xu Wei, Xianglu Liu, Binbin Hu, Yonglei Jiang, Yi Chen   +8 more
doaj   +1 more source

Bibliometric Analysis of Cubebenes and Related Sesquiterpenes: Natural Occurrence, Biosynthesis, Pharmacological Activities, and In‐Silico‐Based Future Therapeutic Potential

eFood, Volume 7, Issue 3, June 2026.
Cubebene‐related sesquiterpenes, found across diverse biological sources, exhibit promising pharmacological activities, including anti‐inflammatory, neuroprotective, and anticancer effects. This review highlights their molecular diversity, ADME profiles, and predicted multitarget interactions, underscoring their therapeutic relevance and potential in ...
Khadija Boualam, Ahmet B. Ortaakarsu, Sohaib Khatib, Mohamed A. Farag, Mansour Sobeh   +4 more
wiley   +1 more source