Results 91 to 100 of about 6,509 (213)

Brain-derived neurotrophic factor modulation in response to oxidative stress and corticosterone: role of scopolamine and mirtazapine

Life Sciences
Major Depressive Disorder (MDD) is a very complex disease, challenging to study and manage. The complexities of MDD require extensive research of its mechanisms to develop more effective therapeutic approaches. Crucial in the context of this disease is the role of brain-derived neurotrophic factor (BDNF) signaling pathway.This manuscript aims to ...
Correia, Ana Salomé, Torrado, Marília, Costa-Coelho, Tiago, Carvalho, Eva Daniela, Inteiro-Oliveira, Sara, Diógenes, Maria José, Pêgo, Ana Paula, Santos, Sofia Duque, Sebastião, Ana M, Vale, Nuno   +9 more
openaire   +3 more sources

Recent trends in analytical methods to determine new psychoactive substances in hair [PDF]

, 2017
New Psychoactive Substances (NPS) belong to several chemical classes, including phenethylamines, piperazines, synthetic cathinones and synthetic cannabinoids.
García Algar, Oscar, KYRIAKOU, CHRYSTALLA, MARINELLI, Enrico, Pellegrini, Manuela, ZAAMI, Simona   +4 more
core   +1 more source

Association Between Cholinesterase Inhibitor‐Overactive Bladder Antimuscarinic Prescribing Cascade and Risk of Delirium and Falls Among Individuals Living With Dementia

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT Background Prescribing cascades occur when cholinesterase inhibitor (ChEI)‐induced urinary incontinence is misinterpreted as a new condition, leading to overactive bladder (OAB) antimuscarinic initiation. We evaluated whether the ChEI‐OAB antimuscarinic prescribing cascade was associated with delirium or falls compared with mirabegron in older
Sarah Beth Tucker, Bryan L. Love, Chijioke M. Okeke, Erin D. Zwick, Chengwen Teng, Jingkai Wei, Ibraheem M. Karaye, Saud Alsahali, Krithika Rajagopalan, Ismaeel Yunusa   +9 more
wiley   +1 more source

Molecular mechanism study on the contribution of open-fire flue-curing technology to tobacco leaf aroma

Chemical and Biological Technologies in Agriculture
This study compared the effects of open-fire flue-curing and conventional curing methods on the aroma and chemical composition of K326 tobacco leaves, aiming to reveal the molecular mechanisms of aroma formation during open-fire flue-curing.
Kaiyuan Gu, Jialiang Li, Lu Zhao, Jiaen Su, Xu Wei, Xianglu Liu, Binbin Hu, Yonglei Jiang, Yi Chen   +8 more
doaj   +1 more source

Is sleep affected after microgravity and hypergravity exposure? A pilot study

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Sleep is known to be affected in space travel and in residents of the international space station. But little is known about the direct effects of gravity changes on sleep, if other factors, such as sleep conditions, are kept constant. Here, as a first exploration, we investigated sleep before and after exposure to short bouts of microgravity ...
Barbara Le Roy, Aurore Jouvencel, Anika Friedl‐Werner, Ludmila Renel, Youcef Cherchali, Raouf Osseiran, Ernesto Sanz‐Arigita, Jean‐René Cazalets, Etienne Guillaud, Ellemarije Altena   +9 more
wiley   +1 more source

Stereochemical studies on protonated bridgehead amines. ^1H NMR determination of cis and trans B-C ring-fused structures for salts of hexahydropyrrolo [2,1-a] isoquinolines and related C ring homologs. Capture of unstable ring-fused structures in the solid state [PDF]

, 1989
Acid-addition salts of tricyclic isoquinolines 2a/b, 3a/b, 4a-4c, 5, 6a/b, 7, 8a/b, 9a/b, and 17a/b were studied by high-field ^1H NMR in CDCl_3 solution.
Inners, Ruth R., Maryanoff, Bruce E., Mayo, Stephen L., McComsey, David F., Mutter, Martin S., Olofson, R. A., Wooden, Gary P.   +6 more
core  

Knocking Out Two Polyphenol Oxidase Genes Significantly Improves Recombinant Protein Purification in Nicotiana benthamiana

Plant Biotechnology Journal, EarlyView.
ABSTRACT Efficient purification remains a key technical challenge affecting the recovery efficiency of recombinant proteins in plant‐based systems. Complex metabolites, particularly polyphenols, often cause recombinant protein aggregation during purification.
Hai‐Ping Diao, Hui‐Xin Meng, Xue‐Jiao Xu, Zeng‐Lin Zhang, Jian‐Feng Zhang, Yong‐Feng Guo, Inhwan Hwang, Shi‐Jian Song   +7 more
wiley   +1 more source

Branch retinal artery occlusion due to patent foramen ovale in a teenager

Experimental Physiology, EarlyView.
Abstract This report demonstrates the diagnostic evaluation and clinical management of a 16‐year‐old girl who developed branch retinal artery occlusion secondary to patent foramen ovale. The goal is to increase awareness of this rare presentation in adolescents among clinicians, with a summary of the important clinical features, multimodal imaging ...
Jie Zu, Fang Fan, Jiayao Wang, Jianmin Wang, Zhiyang Jia   +4 more
wiley   +1 more source

Bibliometric Analysis of Cubebenes and Related Sesquiterpenes: Natural Occurrence, Biosynthesis, Pharmacological Activities, and In‐Silico‐Based Future Therapeutic Potential

eFood, Volume 7, Issue 3, June 2026.
Cubebene‐related sesquiterpenes, found across diverse biological sources, exhibit promising pharmacological activities, including anti‐inflammatory, neuroprotective, and anticancer effects. This review highlights their molecular diversity, ADME profiles, and predicted multitarget interactions, underscoring their therapeutic relevance and potential in ...
Khadija Boualam, Ahmet B. Ortaakarsu, Sohaib Khatib, Mohamed A. Farag, Mansour Sobeh   +4 more
wiley   +1 more source

Preventive Effect of Gallic Acid‐Loaded Carrageenan Nanoparticles Against Cerebral Ischemia/Reperfusion Injury in Rat: Modulation of Oxidative Pathway

Food Science &Nutrition, Volume 14, Issue 5, May 2026.
Oral pretreatment with GA‐CG NPs provided remarkable neuroprotection in a rat model of cerebral ischemia/reperfusion. GA‐CG NPs improved cognition and attenuated depressive‐like behaviors, infarct volume, MDA content, as well as increased dopamine and antioxidant status (SOD, CAT, GPx, GSH) compared with free gallic acid.
Akbar Hajizadeh Moghaddam, Parisa Jahani Bahnamiri, Sedigheh Khanjani Jelodar, Zohre Fendereski Jaz, Parisa Nasiriansari, Vahid Hasantabar   +5 more
wiley   +1 more source