Results 81 to 90 of about 3,294 (199)
Abstract Objective The pathogenesis of epilepsy is closely associated with neuronal synaptic plasticity. MicroRNAs (miRNAs) can regulate various biological processes by binding to specific sequences on target genes. This study employs bioinformatics, molecular dynamics, and experimental approaches to investigate the mechanism by which MiR‐30a‐5p treats
Zhenlin Yang +4 more
wiley +1 more source
Scopolamine is a well-known cholinergic antagonist that causes amnesia in human and animal models. Scopolamine-induced amnesia in rodent models has been widely used to understand the molecular, biochemical, behavioral changes, and to delineate therapeutic targets of memory impairment. Although this has been linked to the decrease in central cholinergic
Arpita Konar +6 more
openaire +4 more sources
Thermosalient materials, or more colloquially called jumping crystals, are a class of materials that exhibit mechanical motion as a response to the thermal stimulus.
Klaser, Teodoro
core
ABSTRACT This study rigorously assessed the impact of folic acid‐fortified whole wheat products on mitigating mild liver injury caused by prolonged excessive folic acid consumption, improving folic acid bioavailability, and enhancing spatial cognitive functions in mice over a 48‐day intervention period.
Yan Qi +3 more
wiley +1 more source
Status Epilepticus Alters the Function of Brain‐Derived Extracellular Vesicles
ABSTRACT Epilepsy is a neurological disorder characterised by recurrent spontaneous seizures. Approximately 30% of patients are unable to achieve adequate seizure control with available medications, highlighting the need to better understand disease mechanisms and develop improved treatments.
Samantha L. Reed +6 more
wiley +1 more source
This review synthesizes EEG findings from 28 VIMS studies across four inducing scenarios (abstract cues, virtual videos, vehicle driving, and game scenes) and two display types (HMD and monitor). While Delta/Theta enhancement consistently reflects sensory conflict, Alpha activity shows context dependency: predominantly increasing during passive viewing
Yanru Bai +5 more
wiley +1 more source
Asymmetric Synthesis of 1,3-Amino Alcohols and Tropinone Derivatives From Enantiopure Sulfinimines
Heterocycles that contain nitrogen, such as piperidine, pyrrolidine and tropane, are widespread as natural product alkaloids and serve as templates for many bioactive drugs and drug candidates.
Gaspari, Paul
core +1 more source
Abstract Objectives We aimed at identifying magnetic resonance enterography (MRE) predictors of surgical intervention and anti‐tumor necrosis factor alpha (TNF‐α) initiation in a paediatric cohort of patients newly diagnosed with isolated ileocaecal (L1) Crohn's disease (CD).
Saverio Pochesci +8 more
wiley +1 more source
The mechanism of pharmacological activity of D2AAK1 and its derivatives
D2AAK1, discovered by our group, has emerged as a promising candidate for the treatment of neurodegenerative diseases due to its cytoprotective, antioxidant, and procognitive properties. This study aimed to further elucidate the mechanisms underlying the
Kaczor, Agnieszka
core +1 more source
Alzheimer’s disease (AD) is characterized by progressive neurodegeneration and impaired cognitive functions. Fascaplysin is a β-carboline alkaloid isolated from marine sponge Fascaplysinopsis bergquist in 1988.
Haixing Wang (2457058) +17 more
core +1 more source

