Results 81 to 90 of about 6,509 (213)

Psychedelic‐assisted treatment for substance use disorder: A narrative systematic review

Addiction, EarlyView.
Abstract Background and aims This is the first systematic review of the extant literature on all major psychedelic‐assisted treatment for alcohol use disorder (AUD), tobacco use disorder (TUD) and other substance use disorders (SUD). We aimed to summarise the evidence for efficacy of psychedelic‐assisted treatment for AUD, TUD, and SUD; to evaluate its
Theodore Piper, Francesca Small, Sam Brown, Michael Kelleher, Luke Mitcheson, James Rucker, Allan H. Young, John Marsden   +7 more
wiley   +1 more source

Attenuation of neurological deficit by a novel ethanolamine derivative in rats after brain trauma

Journal of Experimental Pharmacology, 2019
Yuriy Igorevich Sysoev,1,2 Bright Chukwunwike Uzuegbunam,1 Sergey Vladimirovich Okovityi11Department of Pharmacology and Clinical Pharmacology, Saint-Petersburg State Chemical-Pharmaceutical University, St. Petersburg, Russia; 2Institute of Translational
Sysoev YI, Uzuegbunam BC, Okovityi SV
doaj  

Iridoids and other Mmnoterpenes in the Alzheimer’s Brain: Recent development and future prospects [PDF]

, 2018
Iridoids are a class of monoterpenoid compounds constructed from 10-carbon skeleton of isoprene building units. These compounds in their aglycones and glycosylated forms exist in nature to contribute to mechanisms related to plant defenses and diverse ...
Habtemariam, Habtemariam, Habtemariam, Juan-Badaturugea, Liu, Llusià, Solomon Habtemariam, Vekrellis, Wagner, Wang, Wang, Zhong   +11 more
core   +2 more sources

Preclinical models for evaluating psychedelics in the treatment of major depressive disorder

British Journal of Pharmacology, EarlyView.
Psychedelic drugs have seen a resurgence in interest as a next generation of psychiatric medicines with potential as rapid‐acting antidepressants (RAADs). Despite promising early clinical trials, the mechanisms which underlie the effects of psychedelics are poorly understood.
Laith Alexander, Dasha Anderson, Luke Baxter, Matthew Claydon, James Rucker, Emma S. J. Robinson   +5 more
wiley   +1 more source

Metabolomics analysis of differential metabolites in the fruit pulp of‘Tubtim Siam Red Ruby Pummelo'(Citrus grandis)

Guoshu xuebao
【Objective】Tubtim Siam Red Ruby Pummelo originated from a Thailand's southern city, and fruit flesh was ruby-like, so it got the name for granted. It is currently one of the major cultivars of excellent pummelo in southern China. It is mainly eaten fresh,
LIU Chenglang, YANG Fan, ZHOU Xianyan, GAO Junyan, ZHAO Dongxing, GU Jinlou, WANG Shaohua, GUO Lina, BI Guanglin, ZHAO Aiqiu, YUE Jianqiang, DONG Meichao   +11 more
doaj   +1 more source

Oral Health Care Services, Barriers and Enablers to Maintaining Good Oral Health in Motor Neurone Disease: A Scoping Review

Community Dentistry and Oral Epidemiology, EarlyView.
ABSTRACT Objectives The objective of this scoping review was to map existing literature on oral health and related care in individuals with Motor Neurone Disease (MND). Specifically, the review aimed to identify barriers and facilitators to maintaining oral hygiene, summarise available clinical guidelines and patient‐facing resources, and examine how ...
Mariam A. Khokhar, Lucy A. O'Malley, Anne‐Marie Glenny, Xiaohui Chen   +3 more
wiley   +1 more source

Pharmacological manipulation of L-carnitine transport into L6 cells with stable overexpression of human OCTN2 [PDF]

, 2018
.: The high-affinity Na+-dependent carnitine transporter OCTN2 (SLC22A5) has a high renal expression and reabsorbs most filtered carnitine. To gain more insight into substrate specificity of OCTN2, we overexpressed hOCTN2 in L6 cells and characterized ...
Brooks, H., Bur, D., Krähenbühl, S., Landmann, L., Stieger, B., Todesco, L., Török, M.   +6 more
core  

Neurotoxicity [PDF]

, 2014
Neurotoxicity refers to the direct or indirect effect of chemicals that disrupt the nervous system of humans or animals. Numerous chemicals can produce neurotoxic diseases in humans, and many more are used as experimental tools to disturb or damage the ...
Brust, Creeley, Feldman, Grandjean, Herken, Panzica, Parent, Pessah, Rice, Román, Spencer, Spencer, Tu, Vinken, Yasui, Zawia   +15 more
core   +2 more sources

Impact of Computer‐Aided Detection on Endoscopist's Gaze‐Shift Distance During Colonoscopy: a Randomized Controlled Trial (With Video)

Journal of Gastroenterology and Hepatology, EarlyView.
CADe assistance did not significantly change the gaze‐shift distance overall, but it reduced gaze‐shift distance among CADe‐experienced endoscopists. CADe may be associated with reduced eye strain, depending on the endoscopist's CADe experience. ABSTRACT Background and Aim Computer‐aided detection (CADe) facilitates colorectal lesion detection, but it ...
Shun Ito, Fumiaki Ishibashi, Kosuke Okusa, Kentaro Mochida, Takao Tonishi, Eri Ozaki, Sho Suzuki   +6 more
wiley   +1 more source

Anticholinergic Medication Burden Scales: A Systematic Review

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT Background Anticholinergic burden refers to the cumulative anticholinergic effect of all medications taken by an individual. Anticholinergic burden scales help identify patients at risk of anticholinergic adverse effects and guide prescribing. However, substantial variation exists between scales, with no gold standard identified.
Orla Vennard, Carrie Stewart, Mansi Tolia, Roy L. Soiza, Phyo K. Myint   +4 more
wiley   +1 more source