Results 81 to 90 of about 627,170 (198)

Immunomodulatory Properties of Withania somnifera: Regulation of Innate Immune Cells and Clinical Implications

Phytotherapy Research, Volume 40, Issue 10, Page 5951-5972, October 2026.
ABSTRACT Withania somnifera (L.) Dunal (WS), commonly known as Ashwagandha, is a prominent medicinal herb in Ayurveda, with extensive therapeutic potential attributed to its diverse phytochemical profile. This review critically examines the immunomodulatory properties of WS, focusing on innate immune cell populations, including neutrophils, eosinophils,
Rana Yukta, Sonalika Gupta, Gagandeep Kaur, Partha Sarathi Mondal, Milirani Das, Anagha Ranade, Alok Kumar Srivastava, Sachin Kumar, Manoj Kumar Barthwal, Madhu Dikshit   +9 more
wiley   +1 more source

Credit derivatives: an overview [PDF]

Arising from financial institutions' need to hedge and diversify credit risk, credit derivatives have now become a major investment tool. Almost all credit derivatives take the form of the credit default swap, which transfers default risk from one party ...
David Mengle
core  

Driving Drugs Deeper: Force‐Driven Microneedle Systems for Active Therapy and Their Road Towards Clinical Implementation

Small, Volume 22, Issue 55, 1 October 2026.
Force‐driven microneedles are presented as active therapeutic microdevices that overcome the diffusion limits of conventional patches. By integrating gas generation, magnetic actuation, cavitation, or iontophoresis, these systems drive payloads deeper into tissue, enabling faster, more controlled delivery and highlighting key design principles and ...
Majed Amini, Phoebe Li, Hamed Shahsavan, Mahla Poudineh   +3 more
wiley   +1 more source

Dualsteric and dual‐acting modulation of muscarinic receptors by antagonist KH‐5

British Journal of Pharmacology, Volume 183, Issue 19, Page 5769-5790, October 2026.
Abstract Background and purpose Muscarinic acetylcholine receptors are key therapeutic targets, and ligands engaging both orthosteric and allosteric sites may offer improved selectivity and efficacy. Here, we investigated whether the muscarinic antagonist KH‐5 acts as a dualsteric antagonist and defined its mode of interaction with muscarinic receptors.
Alena Janoušková‐Randáková, Eva Dolejší, Nikolai Chetverikov, Jan Jakubík   +3 more
wiley   +1 more source

Derivatives at Agricultural Banks [PDF]

Using data between 1995 and 2010, we find that agricultural banks are benefiting from the derivatives activities by reducing total risk without hurting their profit.
Hartarska, Valentina M., Shen, Xuan
core  

Muscarinic agonists for schizophrenia: Bridging preclinical evidence and clinical enthusiasm

British Journal of Pharmacology, Volume 183, Issue 19, Page 5701-5731, October 2026.
Abstract Antipsychotic drugs targeting dopamine receptors have been used to treat schizophrenia for decades, primarily alleviating positive symptoms such as hallucinations and delusions. However, they provide limited benefit for cognitive and negative symptoms—major contributors to poor outcomes—and are frequently associated with significant side ...
Brian J. Morris, Judith A. Pratt
wiley   +1 more source

Protective Role of Ashwagandha Leaf Extract and Its Component Withanone on Scopolamine-Induced Changes in the Brain and Brain-Derived Cells

PLoS ONE, 2011
Scopolamine is a well-known cholinergic antagonist that causes amnesia in human and animal models. Scopolamine-induced amnesia in rodent models has been widely used to understand the molecular, biochemical, behavioral changes, and to delineate therapeutic targets of memory impairment. Although this has been linked to the decrease in central cholinergic
Arpita Konar, Navjot Shah, Rumani Singh, Nishant Saxena, Sunil C Kaul, Renu Wadhwa, Mahendra K Thakur   +6 more
openaire   +4 more sources

Molecular mechanism study on the contribution of open-fire flue-curing technology to tobacco leaf aroma

Chemical and Biological Technologies in Agriculture
This study compared the effects of open-fire flue-curing and conventional curing methods on the aroma and chemical composition of K326 tobacco leaves, aiming to reveal the molecular mechanisms of aroma formation during open-fire flue-curing.
Kaiyuan Gu, Jialiang Li, Lu Zhao, Jiaen Su, Xu Wei, Xianglu Liu, Binbin Hu, Yonglei Jiang, Yi Chen   +8 more
doaj   +1 more source

Self‐Directed Mikoto Simulator Training for Colonoscopy in Gastroenterology Trainees: An International Multicenter Randomized Trial

Journal of Gastroenterology and Hepatology, Volume 41, Issue 10, Page 3118-3127, October 2026.
ABSTRACT Objectives Simulation‐based colonoscopy training may support early acquisition of insertion skills, but its clinical effect remains uncertain. We evaluated whether a self‐directed curriculum using the mikoto colonoscopy simulator improved insertion performance in gastroenterology trainees.
Daisuke Yamaguchi, Ryo Shimoda, Masashi Fujii, Tomohiko Richard Ohya, Han‐Mo Chiu, Naoyuki Tominaga, Hidenori Hidaka, Hiroharu Kawakubo, Yosuke Minoda, Kosuke Maehara, Hiroko Fukuda, Takuma Okamura, Kiwamu Tanaka, Masakuni Kobayashi, Tetsuhito Muranaka, Shuichi Miyamoto, Mitsuru Esaki, Ayako Takamori, Yuichiro Ikebuchi, Taro Akashi, Naoyuki Yamaguchi, Masaru Ueki, Hajime Isomoto, Motohiro Esaki   +23 more
wiley   +1 more source

Gastroparesis Phenotyping: Current Methods and Emerging Opportunities With Magnetic Resonance Imaging

Neurogastroenterology &Motility, Volume 38, Issue 10, October 2026.
Anatomical and dynamic MRI performed before and after ingestion of a natural test meal provide complementary assessments of gastric accommodation, emptying, and regional wall kinematics. This integrated, noninvasive examination supports mechanistic phenotyping of gastric motor dysfunction in gastroparesis. ABSTRACT Background Gastroparesis is a complex
Xiaokai Wang, Michael Camilleri, Zhongming Liu   +2 more
wiley   +1 more source