Results 81 to 90 of about 3,294 (199)

MiR‐30a‐5p mediates epileptogenesis in epilepsy models by targeting SOX4 to regulate the Wnt/β‐catenin pathway

open access: yesEpilepsia Open, Volume 11, Issue 3, Page 983-1002, June 2026.
Abstract Objective The pathogenesis of epilepsy is closely associated with neuronal synaptic plasticity. MicroRNAs (miRNAs) can regulate various biological processes by binding to specific sequences on target genes. This study employs bioinformatics, molecular dynamics, and experimental approaches to investigate the mechanism by which MiR‐30a‐5p treats
Zhenlin Yang   +4 more
wiley   +1 more source

Protective Role of Ashwagandha Leaf Extract and Its Component Withanone on Scopolamine-Induced Changes in the Brain and Brain-Derived Cells

open access: yesPLoS ONE, 2011
Scopolamine is a well-known cholinergic antagonist that causes amnesia in human and animal models. Scopolamine-induced amnesia in rodent models has been widely used to understand the molecular, biochemical, behavioral changes, and to delineate therapeutic targets of memory impairment. Although this has been linked to the decrease in central cholinergic
Arpita Konar   +6 more
openaire   +4 more sources

Istraživanje termoodskočnog efekta u N’-2-Propiliden-4-hidroksibenzohidrazidu i derivatima oksitropium bromida

open access: yes, 2023
Thermosalient materials, or more colloquially called jumping crystals, are a class of materials that exhibit mechanical motion as a response to the thermal stimulus.
Klaser, Teodoro
core  

Synergistic Enhancement: Whole Wheat Substrate Improves Memory in Mice by Optimizing Folate Metabolism and Systemic Antioxidant Capacity

open access: yesFood Bioengineering, Volume 5, Issue 2, Page 244-258, June 2026.
ABSTRACT This study rigorously assessed the impact of folic acid‐fortified whole wheat products on mitigating mild liver injury caused by prolonged excessive folic acid consumption, improving folic acid bioavailability, and enhancing spatial cognitive functions in mice over a 48‐day intervention period.
Yan Qi   +3 more
wiley   +1 more source

Status Epilepticus Alters the Function of Brain‐Derived Extracellular Vesicles

open access: yesJournal of Extracellular Vesicles, Volume 15, Issue 6, June 2026.
ABSTRACT Epilepsy is a neurological disorder characterised by recurrent spontaneous seizures. Approximately 30% of patients are unable to achieve adequate seizure control with available medications, highlighting the need to better understand disease mechanisms and develop improved treatments.
Samantha L. Reed   +6 more
wiley   +1 more source

Neurophysiological correlates of visually induced motion sickness severity: A scoping review of the impact of experimental settings on EEG spectral power

open access: yesJournal of Intelligent Medicine, Volume 3, Issue 2, Page 152-168, June 2026.
This review synthesizes EEG findings from 28 VIMS studies across four inducing scenarios (abstract cues, virtual videos, vehicle driving, and game scenes) and two display types (HMD and monitor). While Delta/Theta enhancement consistently reflects sensory conflict, Alpha activity shows context dependency: predominantly increasing during passive viewing
Yanru Bai   +5 more
wiley   +1 more source

Asymmetric Synthesis of 1,3-Amino Alcohols and Tropinone Derivatives From Enantiopure Sulfinimines

open access: yes, 2011
Heterocycles that contain nitrogen, such as piperidine, pyrrolidine and tropane, are widespread as natural product alkaloids and serve as templates for many bioactive drugs and drug candidates.
Gaspari, Paul
core   +1 more source

The prognostic role of magnetic resonance enterography at diagnosis in paediatric isolated ileocaecal Crohn's disease

open access: yesJournal of Pediatric Gastroenterology and Nutrition, Volume 82, Issue 6, Page 1451-1457, June 2026.
Abstract Objectives We aimed at identifying magnetic resonance enterography (MRE) predictors of surgical intervention and anti‐tumor necrosis factor alpha (TNF‐α) initiation in a paediatric cohort of patients newly diagnosed with isolated ileocaecal (L1) Crohn's disease (CD).
Saverio Pochesci   +8 more
wiley   +1 more source

The mechanism of pharmacological activity of D2AAK1 and its derivatives

open access: yes
D2AAK1, discovered by our group, has emerged as a promising candidate for the treatment of neurodegenerative diseases due to its cytoprotective, antioxidant, and procognitive properties. This study aimed to further elucidate the mechanisms underlying the
Kaczor, Agnieszka
core   +1 more source

Fascaplysin Derivatives Are Potent Multitarget Agents against Alzheimer’s Disease: in Vitro and in Vivo Evidence

open access: yes, 2019
Alzheimer’s disease (AD) is characterized by progressive neurodegeneration and impaired cognitive functions. Fascaplysin is a β-carboline alkaloid isolated from marine sponge Fascaplysinopsis bergquist in 1988.
Haixing Wang (2457058)   +17 more
core   +1 more source

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