Results 51 to 60 of about 3,158 (154)

Applications of Bioinorganic Nano‐Based Delivery Systems—Diagnostics and Therapeutics

Drug Development Research, Volume 87, Issue 5, August 2026.
ABSTRACT Nanotechnology has emerged as a promising avenue for producing nanomedicines as alternatives to conventional drugs. Many organic nanoparticles, such as liposomes used in formulations like Doxil, Onivyde, and Marqibo, are approved by the Food and Drug Administration (FDA) and instrumental in treating various types of cancers.
Frank Ssengooba, Jubilee Andrew, Donald Fernandes   +2 more
wiley   +1 more source

Effects of Exogenous Monosodium Glutamate on GABA Accumulation and Volatile/Nonvolatile Metabolites in Black Highland Barley

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
Overview of MSG‐assisted GABA enrichment and associated changes in amino acid, fatty acid, and volatile metabolite profiles in germinated black highland barley. ABSTRACT γ‐Aminobutyric acid (GABA) is a functional amino acid with multiple health benefits; however, the mechanism of its enrichment in black highland barley, particularly through precursor ...
Xiaohang Lu, Nana Ma, Yuan Wang
wiley   +1 more source

Behavioral and Biochemical Effects of an Arylhydrazone Derivative of 5-Methoxyindole-2-Carboxylic Acid in a Scopolamine-Induced Model of Alzheimer’s Type Dementia in Rats

Molecules
Alzheimer’s disease (AD) has long proven to be a complex neurodegenerative disorder, with cholinergic dysfunction, oxidative stress, and neuroinflammation being just a few of its pathological features.
Polina Petkova-Kirova, Neda Anastassova, Borislav Minchev, Diamara Uzunova, Valya Grigorova, Elina Tsvetanova, Almira Georgieva, Albena Alexandrova, Miroslava Stefanova, Denitsa Yancheva, Reni Kalfin, Lyubka Tancheva   +11 more
doaj   +1 more source

Brain-derived neurotrophic factor modulation in response to oxidative stress and corticosterone: role of scopolamine and mirtazapine

Life Sciences
Major Depressive Disorder (MDD) is a very complex disease, challenging to study and manage. The complexities of MDD require extensive research of its mechanisms to develop more effective therapeutic approaches. Crucial in the context of this disease is the role of brain-derived neurotrophic factor (BDNF) signaling pathway.This manuscript aims to ...
Correia, Ana Salomé, Torrado, Marília, Costa-Coelho, Tiago, Carvalho, Eva Daniela, Inteiro-Oliveira, Sara, Diógenes, Maria José, Pêgo, Ana Paula, Santos, Sofia Duque, Sebastião, Ana M, Vale, Nuno   +9 more
openaire   +3 more sources

Volumetric Absorptive Microsampling During Spaceflight for Analysis of Acetaminophen Pharmacokinetics in Whole Blood

The Journal of Clinical Pharmacology, Volume 66, Issue 8, August 2026.
Abstract Spaceflight induces altered physiology that has the potential to alter medication pharmacokinetics due to factors including gastrointestinal motility, fluid balance, circulatory dynamics, hormonal changes, and metabolic alterations. Here, we report the first pharmacokinetic analysis using blood samples during spaceflight.
David Mampre, Robert Guttendorf, Jennifer Zimmer, Brooke Whitson, James Huggins, Chad Christianson, Erik Burns, Nicolas Heft, Marissa Rosenberg, Amran Asadi, Jaime Mateus, James Rudge, Takako Mizuno, John Donehoo   +13 more
wiley   +1 more source

Attenuation of neurological deficit by a novel ethanolamine derivative in rats after brain trauma

Journal of Experimental Pharmacology, 2019
Yuriy Igorevich Sysoev,1,2 Bright Chukwunwike Uzuegbunam,1 Sergey Vladimirovich Okovityi11Department of Pharmacology and Clinical Pharmacology, Saint-Petersburg State Chemical-Pharmaceutical University, St. Petersburg, Russia; 2Institute of Translational
Sysoev YI, Uzuegbunam BC, Okovityi SV
doaj  

The Impact of Aprepitant on Post‐Operative Nausea and Vomiting in Endoscopic Skull Base Surgery

Laryngoscope Investigative Otolaryngology, Volume 11, Issue 4, August 2026.
ABSTRACT Objective Post‐operative nausea and vomiting (PONV) is common following endoscopic skull base surgery despite multimodal prophylaxis and carries a risk of post‐operative bleeding and cerebrospinal fluid (CSF) leakage. This study aims to investigate if pre‐operative administration of the neurokinin‐1 (NK‐1) antagonist, aprepitant, reduces PONV ...
Anuj U. Patel, Cynthia Sun, Hewitt Chang, Jared Clouse, Kiarash Shahlaie, E. Bradley Strong, Toby Steele   +6 more
wiley   +1 more source

In Vivo Evaluation of Psoralen in a Copper Sulfate–Induced Chick (Gallus gallus domesticus) Emesis Model and In Silico Analysis of Its Interaction With D2, 5‐HT3A, and Muscarinic Receptors

ChemistryOpen, Volume 15, Issue 8, August 2026.
Psoralen (PSN) demonstrates significant dose‐dependent antiemetic activity in a copper sulfate–induced chick emesis model. Integrated in vivo and in silico analyses reveal reduced retching frequency, prolonged latency, and favorable multi‐receptor interactions with D2, 5‐HT3A, and muscarinic receptors, highlighting PSN as a promising multi‐target ...
Kishor Chandra, Sharif Uddin Bahar, Khadija Akter, Mst Muslima Khatun, Samiran Sadhukhan, Progna Saha Puja, Fazley Rohan, Md Shimul Bhuia, Mohammed Alfaifi, Faisal H. Altemani, Faisal Alsenani, Salehin Sheikh, Muhammad Torequl Islam   +12 more
wiley   +1 more source

Oral Health Care Services, Barriers and Enablers to Maintaining Good Oral Health in Motor Neurone Disease: A Scoping Review

Community Dentistry and Oral Epidemiology, Volume 54, Issue 4, Page 447-461, August 2026.
ABSTRACT Objectives The objective of this scoping review was to map existing literature on oral health and related care in individuals with Motor Neurone Disease (MND). Specifically, the review aimed to identify barriers and facilitators to maintaining oral hygiene, summarise available clinical guidelines and patient‐facing resources, and examine how ...
Mariam A. Khokhar, Lucy A. O'Malley, Anne‐Marie Glenny, Xiaohui Chen   +3 more
wiley   +1 more source

Metabolomics analysis of differential metabolites in the fruit pulp of‘Tubtim Siam Red Ruby Pummelo'(Citrus grandis)

Guoshu xuebao
【Objective】Tubtim Siam Red Ruby Pummelo originated from a Thailand's southern city, and fruit flesh was ruby-like, so it got the name for granted. It is currently one of the major cultivars of excellent pummelo in southern China. It is mainly eaten fresh,
LIU Chenglang, YANG Fan, ZHOU Xianyan, GAO Junyan, ZHAO Dongxing, GU Jinlou, WANG Shaohua, GUO Lina, BI Guanglin, ZHAO Aiqiu, YUE Jianqiang, DONG Meichao   +11 more
doaj   +1 more source