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Modification of Closed-State Inactivation in Voltage-Gated Sodium Channel Na<sub>v</sub>1.7 by Two Novel Arachnid Toxins. [PDF]
Toxins (Basel)Johnson JW, Rikli HG, Johnson SR.
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Comptes rendus des seances de la Societe de biologie et de ses filiales, 1997
Scorpion are known to use a cocktail of toxins to immobilize their prey. So, their venoms constitute a complex mixture of polypeptides exhibiting different pharmacological activities. These polypeptides are small (between 30 and 70 amino acids long), basic and highly reticulated (3 or 4 disulfide bridges).
André Menez, Marc Dauplais
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Scorpion are known to use a cocktail of toxins to immobilize their prey. So, their venoms constitute a complex mixture of polypeptides exhibiting different pharmacological activities. These polypeptides are small (between 30 and 70 amino acids long), basic and highly reticulated (3 or 4 disulfide bridges).
André Menez, Marc Dauplais
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SCORPION, a molecular database of scorpion toxins
Toxicon, 2002Increasing interest in the studies of toxins and the requirements for better structural and functional annotations have created a need for improved data management in the field of toxins. The molecular database, SCORPION, contains more than 200 entries of fully referenced scorpion toxin data including primary sequences, three-dimensional structures ...
Srinivasan, K.N. +8 more
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Scorpion toxins prefer salt solutions
Journal of Molecular Modeling, 2015There is a wide variety of ion channel types with various types of blockers, making research in this field very complicated. To reduce this complexity, it is essential to study ion channels and their blockers independently. Scorpion toxins, a major class of blockers, are charged short peptides with high affinities for potassium channels.
Azadeh, Nikouee +2 more
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Conformational variations amongst scorpion toxins
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1986Circular dichroism spectra were obtained for ten scorpion neurotoxins (representing five species of scorpion) in order to provide an understanding of their relative conformations in solution. Despite a high degree of amino acid sequence homology, the toxins clearly differ from each other in terms of CD-detectable structure.
M J, Dufton, A F, Drake, H, Rochat
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Radioiodination of scorpion and snake toxins
Analytical Biochemistry, 1977Abstract Several scorpion and snake toxins were radioiodinated using the lactoperoxydase method of [125I]iodide oxidation. Two techniques of labeling were set up: (i) Using carrier-free Na125I and 5 μg of toxin, about one iodine atom was incorporated per mole of protein without loss of toxicity.
H, Rochat +3 more
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1997
Abstract α-Toxins can be considered as the cause of the scorpion venom toxicity for mammals and particularly human beings, in the ‘Old World’ (Miranda et al. 1970). For example, 90 per cent of the toxicity for the mouse in the venom of Androctonus australis from North Africa is due to only 2 per cent of the weight of the crude venom. The
M -F Martin-Eauclaire, P E Bougis
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Abstract α-Toxins can be considered as the cause of the scorpion venom toxicity for mammals and particularly human beings, in the ‘Old World’ (Miranda et al. 1970). For example, 90 per cent of the toxicity for the mouse in the venom of Androctonus australis from North Africa is due to only 2 per cent of the weight of the crude venom. The
M -F Martin-Eauclaire, P E Bougis
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The insecticidal potential of scorpion β-toxins
Toxicon, 2007Voltage-gated sodium channels are a major target for toxins and insecticides due to their central role in excitability, but due to the conservation of these channels in Animalia most insecticides do not distinguish between those of insects and mammals, thereby imposing risks to humans and livestock.
Gurevitz, M. +9 more
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Adaptive Evolution of Scorpion Sodium Channel Toxins
Journal of Molecular Evolution, 2004Gene duplication followed by positive Darwinian selection is an important evolutionary event at the molecular level, by which a gene can gain new functions. Such an event might have occurred in the evolution of scorpion sodium channel toxin genes (alpha- and beta-groups).
Zhu, Shunyi, Bosmans, Frank, Tytgat, Jan
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Scorpion Toxins Affecting Insects
1992Publisher Summary This chapter provides an overview of the scorpion toxins affecting insects. The scorpion toxins specific for insects are divided into two different categories—contraction-inducing toxins, which causes rapid excitatory contraction paralysis in Sarcophaga argyrostoma fly larvae, and depressant toxins, which induces a slow depressant ...
Erwann P. Loret +4 more
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