Results 51 to 60 of about 11,648 (223)

Scorpion venomics: a 2019 overview

Expert Review of Proteomics, 2019
Introduction: A few scorpions are dangerous to humans. Their medical relevance was the initial driving force for venom research. By classical biochemistry and molecular cloning, several venom peptides and their coding transcripts were characterized, mainly those related to toxins.
Jimena I, Cid-Uribe, José Ignacio, Veytia-Bucheli, Teresa, Romero-Gutierrez, Ernesto, Ortiz, Lourival D, Possani   +4 more
openaire   +2 more sources

Animal suicide: An account worth giving? Commentary on Peña-Guzmán on Animal Suicide [PDF]

, 2018
Peña-Guzmán (2017) argues that empirical evidence and evolutionary theory compel us to treat the phenomenon of suicide as continuous in the animal kingdom.
Mikhalevich, Irina
core  

Antiviral activity of animal venom peptides and related compounds [PDF]

, 2017
Viruses exhibit rapid mutational capacity to trick and infect host cells, sometimes assisted through virus-coded peptides that counteract host cellular immune defense.
Mata, Élida Cleyse Gomes da Mata, Mourão, Caroline Barbosa Farias, Rangel, Marisa, Schwartz, Elisabeth Nogueira Ferroni   +3 more
core   +2 more sources

Animal Venoms as Peptide Libraries for the Discovery of Antiglioblastoma Agents

Biochemistry Research International, Volume 2026, Issue 1, 2026.
Glioblastoma is one of the most aggressive and widely recognized types of brain tumors, characterized by significant cellular and molecular diversity and an inherently aggressive nature. The treatment remains highly challenging, with limited effectiveness and persistently low survival rates.
Livia Ramos Santiago, Edgar Alejandro Pinos Tamayo, Daniel Moreira dos Santos, Bonglee Kim, José R. Almeida, Rosy Iara Maciel de Azambuja Ribeiro, Marco Eigenfeld   +6 more
wiley   +1 more source

Polysaccharide Adjuvants as Innate Immune Trainers: Bridging Pattern Recognition Receptor (PRR) Activation and Metabolic Reprogramming for Synthetic Vaccine Design

Advanced Science, Volume 12, Issue 48, December 29, 2025.
Polysaccharides modulate immune responses by engaging pattern recognition receptors (PRRs) to induce T‐cell activation. In vaccine design, their particle size critically influences lymph node targeting and activation mechanisms. By engineering structural complexity and multivalent PRR engagement, polysaccharides enable precise modulation of immune ...
Jeong Hyun Moon, May Thazin Phoo, Yubin Kim, Jinsung Ahn, April Kim, Jutaek Nam, Soo‐Hong Lee, James J. Moon, Sejin Son   +8 more
wiley   +1 more source

Pond frog as a predator of hornet workers: High tolerance to venomous stings

Ecosphere, Volume 16, Issue 12, December 2025.
Abstract Some animals use stingers to repel attackers, and some predators have evolved tolerance to such stings, enabling them to consume venomous prey. For example, social wasps, such as hornets, use modified ovipositors as venomous stingers to inject venom, which can cause intense pain in humans.
Shinji Sugiura
wiley   +1 more source

Functional Properties and Toxin Pharmacology of a Dorsal Root Ganglion Sodium Channel Viewed through its Voltage Sensors [PDF]

, 2013
The voltage-activated sodium (Nav) channel Nav1.9 is expressed in dorsal root ganglion (DRG) neurons where it is believed to play an important role in nociception.
Bean, Bruce Palmer, Bosmans, Frank, Martin-Eauclaire, Marie-France, Puopolo, Michelino, Swartz, Kenton J.   +4 more
core   +1 more source

A Cell‐Penetrating Scorpion Venom Peptide Disrupts the HSP90β‐PPARα Interaction to Ameliorate Metabolic Dysfunction‐Associated Steatotic Liver Disease

iMetaMed, Volume 1, Issue 2, December 2025.
In MASLD, increased HSP90β interacts with PPARα, thereby inhibiting PPARα activation via the inhibition of its nuclear translocation. BmK Tx‐2, a cell‐penetrating peptide from Buthus martensii Karsch scorpion venom, enters hepatocytes via macropinocytosis and escapes endosomes to bind HSP90β.
Erjin Xu, Wuguang Lu, Yonggen Chen, Ming Sang, Jiao Chen, Xueting Cai, Wenhao Xu, Yuxin Zhang, Zhiheng Wang, Feng Zhang, Peng Cao   +10 more
wiley   +1 more source

Venomics of the scorpion Tityus ocelote (Scorpiones, Buthidae): Understanding venom evolution in the subgenus Archaeotityus

International Journal of Peptide Research and Therapeutics, 2022
AbstractThe subgenusTityus (Archaeotityus)includes small variegated species considered until recently, a basal group withinTityus, one of the most diverse and medically relevant genera of scorpions in the New World.Archaeotityusspecies are distributed in the humid forests of Lower Central America and the Choco, Guiana Shield, and Amazon regions. Due to
Díaz Oreiro, Cecilia, Chang Castillo, Arturo, Lomonte, Bruno, Bonilla Murillo, Fabián, Víquez, Carlos, Alfaro Chinchilla, Adriana, Triana Ricón, Felipe, Sasa Marín, Mahmood   +7 more
openaire   +2 more sources

Intervertebral Disc Proteoglycans: Multifunctional Tissue Stabilizing and Instructional Cell Regulatory Proteins That Control Tissue Homeostasis

JOR SPINE, Volume 8, Issue 4, December 2025.
Matrix and cell‐associated proteoglycans are important tissue‐stabilizing, weight‐bearing, and tension‐resisting proteins in the intervertebral disc. Their glycosaminoglycan components have growth factor binding and cell‐instructive properties that allow cells to regulate tissue composition and function.
James Melrose
wiley   +1 more source