Results 61 to 70 of about 356,030 (194)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, Volume 20, Issue 6, Page 1398-1419, June 2026.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Characterization of two different peptides from the venom of the scorpion Buthus sindicus [PDF]

FEBS Letters, 1989
Two disulfide‐rich, low‐molecular mass peptides (~3 kDa and ~4 kDa) have been isolated from Buthus sindicus venom using ion‐exchange and reverse‐phase HPLC. Peptide I has 35 residues with 8 half‐cystine residues and is clearly related to four‐disulfide core proteins of the neurophysin type and to toxins of other scorpion species (55–63% residue ...
Fazal, Annul, Beg, Obaid U., Shafqat, Jawed, Zaidi, Zafar H., Jörnvall, Hans   +4 more
openaire   +2 more sources

Emerging cures for cancer: peptides from scorpion and spider venom

Highlights in Science, Engineering and Technology, 2022
Animal toxins have shown applicability in treatments of various diseases, here some investigations of scorpion and spider venom peptides as cancer treatments have been presented. Scorpion peptides are believed to have antitumor and analgesic effects and may present the potential to be applied in human medicine as a drug for cancer.
Jiayi He, Yedong Xue
openaire   +1 more source

Conkazal‐M1 from the MKAVA family of conotoxins: A dual‐function protease inhibitor and neuroactive peptide

Protein Science, Volume 35, Issue 5, May 2026.
Abstract Marine cone snails produce a diverse array of bioactive peptides, known as conotoxins, in their venom. Given their high target potency and specificity, conotoxins are attractive compounds for the development of precision research tools and pharmacological agents.
Celeste M. Hackney, Thomas Lund Koch, Nicklas Lund Ryding, Aymeric Rogalski, Kevin Chase, Matías Leonel Giglio, Samuel S. Espino, Zildjian G. Acyatan, Maren Watkins, Baldomero M. Olivera, Helena Safavi‐Hemami, Kaare Teilum, Lars Ellgaard   +12 more
wiley   +1 more source

The effect of lysine substitutions in the biological activities of the scorpion venom peptide VmCT1

European Journal of Pharmaceutical Sciences, 2019
Antimicrobial peptides (AMPs) are biologically active molecules with a broad-spectrum activity against a myriad of microorganisms. Aside from their antimicrobial functions, AMPs present physicochemical and structural properties that allow them to exert activity against other kind of cells, such as cancer cells.
Cibele Nicolaski, Pedron, Cyntia Silva, de Oliveira, Adriana Farias, da Silva, Gislaine Patricia, Andrade, Maria Aparecida, da Silva Pinhal, Giselle, Cerchiaro, Pedro Ismael, da Silva Junior, Fernanda Dias, da Silva, Marcelo Der Torossian, Torres, Vani Xavier, Oliveira   +9 more
openaire   +2 more sources

Pharmacological and therapeutic applications of scorpion venom peptides: A Review [PDF]

Introduction: In recent years, scorpion venom and its peptide compounds have attracted growing scientific interest. A remarkable biological diversity and strong therapeutic potential characterize these compounds.
Abdessamad, Elmourid, KHADRA, Ahmed, BOUIMEJA, Btissam, Namiq, Siham, TOULOUN, Oulaid   +4 more
core   +1 more source

Protective Role of Holothuria leucospilota Extract Against Amyloid‐β Toxicity via Autophagy and Antioxidant Mechanisms in Caenorhabditis elegans Model

Oxidative Medicine and Cellular Longevity, Volume 2026, Issue 1, 2026.
Alzheimer’s disease (AD) is a major global health challenge characterized by cognitive decline and neuronal degeneration driven by amyloid‐β (Aβ) aggregation and oxidative stress. Given the limited efficacy and adverse effects of current pharmacological therapies, food‐derived bioactive compounds have gained increasing attention as potential preventive
Chanathip Kamonnat, Salinthip Thongdechsri, Pichnaree Kraokaew, Nakorn Niamnont, Prasert Sobhon, Krai Meemon, Lidija Milkovic   +6 more
wiley   +1 more source

Polysaccharide Adjuvants as Innate Immune Trainers: Bridging Pattern Recognition Receptor (PRR) Activation and Metabolic Reprogramming for Synthetic Vaccine Design

Advanced Science, Volume 12, Issue 48, December 29, 2025.
Polysaccharides modulate immune responses by engaging pattern recognition receptors (PRRs) to induce T‐cell activation. In vaccine design, their particle size critically influences lymph node targeting and activation mechanisms. By engineering structural complexity and multivalent PRR engagement, polysaccharides enable precise modulation of immune ...
Jeong Hyun Moon, May Thazin Phoo, Yubin Kim, Jinsung Ahn, April Kim, Jutaek Nam, Soo‐Hong Lee, James J. Moon, Sejin Son   +8 more
wiley   +1 more source

Venom Gland Transcriptomic and Proteomic Analyses of the Enigmatic Scorpion Superstitionia donensis (Scorpiones: Superstitioniidae), with Insights on the Evolution of Its Venom Components

Toxins, 2016
Venom gland transcriptomic and proteomic analyses have improved our knowledge on the diversity of the heterogeneous components present in scorpion venoms. However, most of these studies have focused on species from the family Buthidae.
Carlos E. Santibáñez-López, Jimena I. Cid-Uribe, Cesar V. F. Batista, Ernesto Ortiz, Lourival D. Possani   +4 more
doaj   +1 more source

Pond frog as a predator of hornet workers: High tolerance to venomous stings

Ecosphere, Volume 16, Issue 12, December 2025.
Abstract Some animals use stingers to repel attackers, and some predators have evolved tolerance to such stings, enabling them to consume venomous prey. For example, social wasps, such as hornets, use modified ovipositors as venomous stingers to inject venom, which can cause intense pain in humans.
Shinji Sugiura
wiley   +1 more source