Results 41 to 50 of about 2,790 (169)

Conkazal‐M1 from the MKAVA family of conotoxins: A dual‐function protease inhibitor and neuroactive peptide

Protein Science, Volume 35, Issue 5, May 2026.
Abstract Marine cone snails produce a diverse array of bioactive peptides, known as conotoxins, in their venom. Given their high target potency and specificity, conotoxins are attractive compounds for the development of precision research tools and pharmacological agents.
Celeste M. Hackney, Thomas Lund Koch, Nicklas Lund Ryding, Aymeric Rogalski, Kevin Chase, Matías Leonel Giglio, Samuel S. Espino, Zildjian G. Acyatan, Maren Watkins, Baldomero M. Olivera, Helena Safavi‐Hemami, Kaare Teilum, Lars Ellgaard   +12 more
wiley   +1 more source

Proteomic endorsed transcriptomic profiles of venom glands from Tityus obscurus and T. serrulatus scorpions. [PDF]

PLoS ONE, 2018
Except for the northern region, where the Amazonian black scorpion, T. obscurus, represents the predominant and most medically relevant scorpion species, Tityus serrulatus, the Brazilian yellow scorpion, is widely distributed throughout Brazil, causing ...
Ursula Castro de Oliveira, Milton Yutaka Nishiyama, Maria Beatriz Viana Dos Santos, Andria de Paula Santos-da-Silva, Hipócrates de Menezes Chalkidis, Andreia Souza-Imberg, Denise Maria Candido, Norma Yamanouye, Valquíria Abrão Coronado Dorce, Inácio de Loiola Meirelles Junqueira-de-Azevedo   +9 more
doaj   +1 more source

ScorpDb: A Novel Open-Access Database for Integrative Scorpion Toxinology

Toxins
Scorpion stings are a significant public health concern globally, particularly in tropical and subtropical regions. Scorpion venoms contain a diverse array of bioactive peptides, and different scorpion species around the world typically exhibit varying ...
Masoumeh Baradaran, Fatemeh Salabi, Masoud Mahdavinia, Elaheh Mohammadi, Babak Vazirianzadeh, Ignazio Avella, Seyed Mahdi Kazemi, Tim Lüddecke   +7 more
doaj   +1 more source

Short Peptides from Asian Scorpions: Bioactive Molecules with Promising Therapeutic Potential

Toxins
Scorpion venom peptides, particularly those derived from Asian species, have garnered significant attention, offering therapeutic potential in pain management, cancer, anticoagulation, and infectious diseases.
Kaiyun Xin, Ruize Sun, Wanyang Xiao, Weijie Lu, Chenhui Sun, Jietao Lou, Yanyan Xu, Tianbao Chen, Di Wu, Yitian Gao   +9 more
doaj   +1 more source

Polysaccharide Adjuvants as Innate Immune Trainers: Bridging Pattern Recognition Receptor (PRR) Activation and Metabolic Reprogramming for Synthetic Vaccine Design

Advanced Science, Volume 12, Issue 48, December 29, 2025.
Polysaccharides modulate immune responses by engaging pattern recognition receptors (PRRs) to induce T‐cell activation. In vaccine design, their particle size critically influences lymph node targeting and activation mechanisms. By engineering structural complexity and multivalent PRR engagement, polysaccharides enable precise modulation of immune ...
Jeong Hyun Moon, May Thazin Phoo, Yubin Kim, Jinsung Ahn, April Kim, Jutaek Nam, Soo‐Hong Lee, James J. Moon, Sejin Son   +8 more
wiley   +1 more source

Hyperpolarization Modulation of the T‐Type hCav3.2 Channel by Human Synenkephalin [1–53], a Shrew Neurotoxin Analogue without Paralytic Effects

Angewandte Chemie, Volume 137, Issue 27, July 1, 2025.
Human synenkephalin [1–53] (hSYN), an analogue peptide of shrew saliva neurotoxins, was synthesized and its structural characteristics studied. Synthetic hSYN potently activated the T‐type voltage‐gated Ca channel hCav3.2 but did not paralyze mealworms. These findings offer new insight into neurological disorder treatment and evolutionary mechanisms of
Ryo Fukuoka, Yusuke Yano, Nozomi Hara, Chihiro Sadamoto, Andres D. Maturana, Masaki Kita   +5 more
wiley   +2 more sources

A Combinational Strategy upon RNA Sequencing and Peptidomics Unravels a Set of Novel Toxin Peptides in Scorpion Mesobuthus martensii

Toxins, 2016
Scorpion venom is deemed to contain many toxic peptides as an important source of natural compounds. Out of the two hundred proteins identified in Mesobuthus martensii (M. martensii), only a few peptide toxins have been found so far.
Ning Luan, Wang Shen, Jie Liu, Bo Wen, Zhilong Lin, Shilong Yang, Ren Lai, Siqi Liu, Mingqiang Rong   +8 more
doaj   +1 more source

Pond frog as a predator of hornet workers: High tolerance to venomous stings

Ecosphere, Volume 16, Issue 12, December 2025.
Abstract Some animals use stingers to repel attackers, and some predators have evolved tolerance to such stings, enabling them to consume venomous prey. For example, social wasps, such as hornets, use modified ovipositors as venomous stingers to inject venom, which can cause intense pain in humans.
Shinji Sugiura
wiley   +1 more source

Characterization of two different peptides from the venom of the scorpion Buthus sindicus [PDF]

FEBS Letters, 1989
Two disulfide‐rich, low‐molecular mass peptides (~3 kDa and ~4 kDa) have been isolated from Buthus sindicus venom using ion‐exchange and reverse‐phase HPLC. Peptide I has 35 residues with 8 half‐cystine residues and is clearly related to four‐disulfide core proteins of the neurophysin type and to toxins of other scorpion species (55–63% residue ...
Fazal, Annul, Beg, Obaid U., Shafqat, Jawed, Zaidi, Zafar H., Jörnvall, Hans   +4 more
openaire   +2 more sources

Emerging cures for cancer: peptides from scorpion and spider venom

Highlights in Science, Engineering and Technology, 2022
Animal toxins have shown applicability in treatments of various diseases, here some investigations of scorpion and spider venom peptides as cancer treatments have been presented. Scorpion peptides are believed to have antitumor and analgesic effects and may present the potential to be applied in human medicine as a drug for cancer.
Jiayi He, Yedong Xue
openaire   +1 more source