Results 31 to 40 of about 2,790 (169)
Exon Shuffling and Origin of Scorpion Venom Biodiversity
Toxins, 2016 Scorpion venom is a complex combinatorial library of peptides and proteins with multiple biological functions. A combination of transcriptomic and proteomic techniques has revealed its enormous molecular diversity, as identified by the presence of a ...
Xueli Wang, Bin Gao, Shunyi Zhu
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A simple protocol for venom peptide barcoding in scorpions
EuPA Open Proteomics, 2014 AbstractScorpion venoms contain many species-specific peptides which target ion channels in cell membranes. Without harming the scorpions, these peptides can easily be extracted and detected by MALDI-TOF mass spectrometry. So far, only few studies compared the venom of different species solely for taxonomic purposes.
Schaffrath, Stephan, Predel, Reinhard
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Anticoagulant Activity of Low-Molecular Weight Compounds from Heterometrus laoticus Scorpion Venom
Toxins, 2017 Scorpion venoms are complex polypeptide mixtures, the ion channel blockers and antimicrobial peptides being the best studied components. The coagulopathic properties of scorpion venoms are poorly studied and the data about substances exhibiting these ...
Thien Vu Tran +8 more
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Evolution Stings: The Origin and Diversification of Scorpion Toxin Peptide Scaffolds
Toxins, 2013 The episodic nature of natural selection and the accumulation of extreme sequence divergence in venom-encoding genes over long periods of evolutionary time can obscure the signature of positive Darwinian selection.
Kartik Sunagar +6 more
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Drug design, development and therapy, 2020 To date, the success of conventional chemotherapy, radiotherapy, and targeted biological therapies in cancer treatment is not satisfactory. The main reasons for such outcomes rely on low target selectivity, primarily in chemo- and radiotherapy, ineffectiveness to metastatic disease, drug resistance, and severe side effects.
Mikaelian,Arthur G +6 more
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Toxins, 2019 Various bioactive peptides have been identified in scorpion venom, but there are many scorpion species whose venom has not been investigated. In this study, we characterized venom components of the North African scorpion, Buthacus leptochelys, by mass ...
Yusuke Yoshimoto +5 more
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ToxinsMore recently, short peptides in scorpion venom have received much attention because of their potential for drug discovery. Although various biological effects of these short peptides have been found, their studies have been hindered by the lack of ...
Ling Zeng +8 more
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The Enzymatic Core of Scorpion Venoms
Toxins, 2022 Enzymes are an integral part of animal venoms. Unlike snakes, in which enzymes play a primary role in envenomation, in scorpions, their function appears to be ancillary in most species.
Gustavo Delgado-Prudencio +5 more
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Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, Volume 20, Issue 6, Page 1398-1419, June 2026.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Mass fingerprinting of the venom and transcriptome of venom gland of scorpion Centruroides tecomanus. [PDF]
PLoS ONE, 2013 Centruroides tecomanus is a Mexican scorpion endemic of the State of Colima, that causes human fatalities. This communication describes a proteome analysis obtained from milked venom and a transcriptome analysis from a cDNA library constructed from two ...
Laura L Valdez-Velázquez +4 more
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