Results 31 to 40 of about 356,030 (194)

Antibacterial Activity and Toxicity of Analogs of Scorpion Venom IsCT Peptides [PDF]

Antibiotics, 2017
Seven analogs of the natural, α-helix peptides IsCT1 and IsCT2—found in the venom of scorpion Opithancatus Madagascariensis—have been synthesized and tested to compare their antibacterial and hemolytic activity against natural peptides. In general, results show that increasing hydrophobicity by substituting positions 5 and 9 of the sequences with ...
Bea, Roberto De la Salud, Petraglia, Adam, Ascuitto, Michael, Buck, Quentin   +3 more
openaire   +2 more sources

Chaperone-mediated native folding of a β-scorpion toxin in the periplasm of E.coli [PDF]

, 2014
Background: Animal neurotoxin peptides are valuable probes for investigating ion channel structure/function relationships and represent lead compounds for novel therapeutics and insecticides.
Cole, Ambrose R., Lampert, A., Wallace, Bonnie A., O’Reilly, A.O., Lopes, J.L.S.   +4 more
core   +1 more source

Venom chemistry and ecology of Australian scorpions [PDF]

, 2022
Edward Evans studied multiple Australian scorpion species, focusing on poorly understood aspects of scorpion venom chemistry and ecological drivers of venom variation. Novel peptides were characterised, and small molecules identified from scorpion venoms.
Evans, Edward Robert Jonathan
core   +1 more source

TanP: A Multifunctional Anionic Peptide From Tityus stigmurus Scorpion Venom [PDF]

Frontiers in Molecular Biosciences, 2022
Anionic peptides of scorpions are molecules rich in aspartic and/or glutamic acid residues and correspond to a class of peptides without disulfide bonds that are still little explored. TanP is a linear anionic peptide (50 amino acid residues and net charge −20) present in the venom gland of the scorpion, Tityus stigmurus, with chelating properties for ...
Menilla Maria Alves de Melo, Verônica da Silva Oliveira, Moacir Fernandes de Queiroz Neto, Weslley de Souza Paiva, Manoela Torres-Rêgo, Manoela Torres-Rêgo, Sérgio Ruschi Bergamachi Silva, Daniel de Lima Pontes, Hugo Alexandre Oliveira Rocha, Miguel Ângelo Fonseca de Souza, Arnóbio Antônio da Silva-Júnior, Matheus de Freitas Fernandes-Pedrosa   +11 more
openaire   +3 more sources

Scorpion Venom Heat-Resistant Peptide Attenuates Microglia Activation and Neuroinflammation [PDF]

Frontiers in Pharmacology, 2021
Background: Intervention of neuroinflammation in central nervous system (CNS) represents a potential therapeutic strategy for a host of brain disorders. The scorpion Buthus martensii Karsch (BmK) and its venom have long been used in the Orient to treat inflammation-related diseases such as rhumatoid arthritis and chronic pain.
Xue-Fei Wu, Xue-Fei Wu, Chun Li, Guang Yang, Ying-Zi Wang, Yan Peng, Dan-Dan Zhu, Ao-Ran Sui, Qiong Wu, Qi-Fa Li, Bin Wang, Na Li, Yue Zhang, Bi-Ying Ge, Jie Zhao, Shao Li, Shao Li   +16 more
openaire   +3 more sources

BmK-YA, an Enkephalin-Like Peptide in Scorpion Venom

PLoS ONE, 2012
By screening extracts of venom from the Asian scorpion Buthus martensii Karsch (BmK) for their abilities to activate opioid receptors, we have identified BmK-YA, an amidated peptide containing an enkephalin-like sequence. BmK-YA is encoded by a precursor that displays a signal sequence and contains four copies of BmK-YA sequences and four of His(4)-BmK-
Zhang, Yan, Xu, Junyan, Wang, Zhiwei, Zhang, Xiuli, Liang, Xinmiao, Civelli, Olivier   +5 more
openaire   +5 more sources

Cysteine-free peptides in scorpion venom: geographical distribution, structure-function relationship and mode of action [PDF]

, 2010
Scorpion venoms are well known sources of Na+-channel, K+-channel, Cl--channel, Ca2+-channel and ryanodine channel selective peptides. In 1993, the first cysteine-free peptide was isolated from scorpionvenom.
Du Plessis, L, Du Plessis, J, Elgar, D
core   +1 more source

Scorpion Venom and Its Different Peptides Aid in Treatment Focusing on Cancer Disease with the Mechanism of Action

Trends in Pharmacy
Animal venoms, especially those from scorpions, have garnered interest for their potential therapeutic uses. Scorpion venom is a complex mixture of bioactive compounds, including neurotoxins, enzymes, enzyme inhibitors, and peptides. These peptides have
Radwa Abdallnasser Amen, Gamal Eldein Fathy Abd-Ellatef   +1 more
doaj   +5 more sources

Animal Venoms as Peptide Libraries for the Discovery of Antiglioblastoma Agents. [PDF]

Biochem Res Int
Glioblastoma is one of the most aggressive and widely recognized types of brain tumors, characterized by significant cellular and molecular diversity and an inherently aggressive nature. The treatment remains highly challenging, with limited effectiveness and persistently low survival rates.
Santiago LR, Pinos Tamayo EA, Moreira Dos Santos D, Kim B, Almeida JR, Ribeiro RIMA.   +5 more
europepmc   +2 more sources

Oral Acute Toxicity and Genotoxicity of Heteroctenus junceus Scorpion Venom. [PDF]

Vet Med Sci
The Heteroctenus junceus scorpion venom is a very popular natural extract used in traditional medicine in Cuba. In clinically relevant experimental settings, scorpion venom does not induce general toxicity or an increase in the frequency of micronucleus formation in erythrocytes.
Díaz-García A, Ruiz-Fuentes JL, Mejias Medina S, Zapata Guajardo N, Ross Skarneo C.   +4 more
europepmc   +2 more sources