Results 11 to 20 of about 356,030 (194)
Antimicrobial Potential of Scorpion-Venom-Derived Peptides
MoleculesThe frequent and irrational use of antibiotics by humans has led to the escalating rise of antimicrobial resistance (AMR) with a high rate of morbidity-mortality worldwide, which poses a challenge to the development of effective treatments.
Zhiqiang Xia +5 more
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Functional evolution of scorpion venom peptides with an inhibitor cystine knot fold [PDF]
Bioscience Reports, 2013 The ICK (inhibitor cystine knot) defines a large superfamily of polypeptides with high structural stability and functional diversity. Here, we describe a new scorpion venom-derived K+ channel toxin (named λ-MeuKTx-1) with an ICK fold through gene ...
Bin Gao +5 more
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Partial purification of peptides present in the Tityus macrochirus (Buthidae) scorpion venom and preliminary assessment of their cytotoxicity [PDF]
Biomédica: revista del Instituto Nacional de Salud, 2017 Introduction: Scorpion venom contains peptides with neurotoxic action primarily active on ion channels in the nervous system of insects and mammals. They are also characterized as cytolytic and anticancer, biological characteristics that have not yet ...
Clara Andrea Rincón-Cortés +2 more
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Antibiotics, 2021 Scorpion venom is a mixture of bioactive peptides, among which neurotoxins and antimicrobial peptides serve especially vital functions. Scorpion venom peptides in Buthidae species have been well described, but toxic peptides from non-Buthidae species ...
Dangui He +3 more
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Scorpion Venom: Detriments and Benefits
Biomedicines, 2020 Scorpion venom may cause severe medical complications and untimely death if injected into the human body. Neurotoxins are the main components of scorpion venom that are known to be responsible for the pathological manifestations of envenoming.
Shirin Ahmadi +8 more
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ToxinsMore recently, short peptides in scorpion venom have received much attention because of their potential for drug discovery. Although various biological effects of these short peptides have been found, their studies have been hindered by the lack of ...
Ling Zeng +8 more
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Exon Shuffling and Origin of Scorpion Venom Biodiversity
Toxins, 2016 Scorpion venom is a complex combinatorial library of peptides and proteins with multiple biological functions. A combination of transcriptomic and proteomic techniques has revealed its enormous molecular diversity, as identified by the presence of a ...
Xueli Wang, Bin Gao, Shunyi Zhu
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FEBS Open Bio, 2021 Buthus occitanus (B. occitanus) is one of the most dangerous scorpions in the world. Despite the involvement of B. occitanus scorpion in severe cases of envenomation in Morocco, no study has focused yet on the proteomic composition of the Moroccan B ...
Khadija Daoudi +8 more
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Short-Chained Linear Scorpion Peptides: A Pool for Novel Antimicrobials
AntibioticsScorpion venom peptides are generally classified into two main groups: the disulfide bridged peptides (DBPs), which usually target membrane-associated ion channels, and the non-disulfide bridged peptides (NDBPs), a smaller group with multifunctional ...
Tolis Panayi +5 more
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Mass fingerprinting of the venom and transcriptome of venom gland of scorpion Centruroides tecomanus. [PDF]
PLoS ONE, 2013 Centruroides tecomanus is a Mexican scorpion endemic of the State of Colima, that causes human fatalities. This communication describes a proteome analysis obtained from milked venom and a transcriptome analysis from a cDNA library constructed from two ...
Laura L Valdez-Velázquez +4 more
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