Results 11 to 20 of about 2,790 (169)

Animal Venom Pharmacological Resources: Exploiting Bioactive Peptides to Target Multi-Drug-Resistant Bacteria. [PDF]

Biochem Res Int
Background The escalating rise of multi–drug‐resistant (MDR) bacterial strains significantly threatens global health, creating a “silent pandemic” prompted by natural selection, gene mutation, and horizontal gene transfer. This crisis is worsened by the deficit in the development of new treatments, necessitating the innovative discovery of new potent ...
Jaber R, Mattei C, Accary C, Roufayel R, Abi Khattar Z, Fajloun Z.   +5 more
europepmc   +2 more sources

Animal Venoms as Peptide Libraries for the Discovery of Antiglioblastoma Agents. [PDF]

Biochem Res Int
Glioblastoma is one of the most aggressive and widely recognized types of brain tumors, characterized by significant cellular and molecular diversity and an inherently aggressive nature. The treatment remains highly challenging, with limited effectiveness and persistently low survival rates.
Santiago LR, Pinos Tamayo EA, Moreira Dos Santos D, Kim B, Almeida JR, Ribeiro RIMA.   +5 more
europepmc   +2 more sources

Oral Acute Toxicity and Genotoxicity of Heteroctenus junceus Scorpion Venom. [PDF]

Vet Med Sci
The Heteroctenus junceus scorpion venom is a very popular natural extract used in traditional medicine in Cuba. In clinically relevant experimental settings, scorpion venom does not induce general toxicity or an increase in the frequency of micronucleus formation in erythrocytes.
Díaz-García A, Ruiz-Fuentes JL, Mejias Medina S, Zapata Guajardo N, Ross Skarneo C.   +4 more
europepmc   +2 more sources

TanP: A Multifunctional Anionic Peptide From Tityus stigmurus Scorpion Venom [PDF]

Frontiers in Molecular Biosciences, 2022
Anionic peptides of scorpions are molecules rich in aspartic and/or glutamic acid residues and correspond to a class of peptides without disulfide bonds that are still little explored. TanP is a linear anionic peptide (50 amino acid residues and net charge −20) present in the venom gland of the scorpion, Tityus stigmurus, with chelating properties for ...
Menilla Maria Alves de Melo, Verônica da Silva Oliveira, Moacir Fernandes de Queiroz Neto, Weslley de Souza Paiva, Manoela Torres-Rêgo, Manoela Torres-Rêgo, Sérgio Ruschi Bergamachi Silva, Daniel de Lima Pontes, Hugo Alexandre Oliveira Rocha, Miguel Ângelo Fonseca de Souza, Arnóbio Antônio da Silva-Júnior, Matheus de Freitas Fernandes-Pedrosa   +11 more
openaire   +3 more sources

Mass-Spectrometry-Based Lipidome and Proteome Profiling of Hottentotta saulcyi (Scorpiones: Buthidae) Venom

Toxins, 2022
Scorpion venom is a complex secretory mixture of components with potential biological and physiological properties that attracted many researchers due to promising applications from clinical and pharmacological perspectives.
Parviz Ghezellou, Kevin Jakob, Javad Atashi, Alireza Ghassempour, Bernhard Spengler   +4 more
doaj   +1 more source

Acetylcholinesterase inhibitory potential of scorpion venom in Aedes aegypti (Diptera: Culicidae) [PDF]

Brazilian Journal of Biology, 2022
Scorpion venom contains a variety of neurotoxins which interact with ion channels and affect their activities. The present study was designed to evaluate the potential of scorpion venom as acetylcholinesterase (AChE) inhibitor by using Aedes aegypti as ...
N. Riaz, F. Zubair, N. Amjad, S. Ashraf, S. Asghar, M. Z. Awan, S. Javaid   +6 more
doaj   +1 more source

Comparative venom gland transcriptome analysis of the scorpion Lychas mucronatus reveals intraspecific toxic gene diversity and new venomous components

BMC Genomics, 2010
Background Lychas mucronatus is one scorpion species widely distributed in Southeast Asia and southern China. Anything is hardly known about its venom components, despite the fact that it can often cause human accidents.
Zhijian Cao, Yingliang Wu, Zhiyong Di, Yawen He, Yibao Ma, Ruiming Zhao, Wenxin Li   +6 more
doaj   +1 more source

Antimicrobial peptides from scorpion venoms

Toxicon, 2014
The need for new antimicrobial agents is becoming one of the most urgent requirements in modern medicine. The venoms of many different species are rich sources of biologically active components and various therapeutic agents have been characterized including antimicrobial peptides (AMPs).
Harrison, Patrick L., Abdel-Rahman, Mohamed A., Miller, Keith, Strong, Peter N.   +3 more
openaire   +2 more sources

Scorpion Venom Heat-Resistant Peptide Attenuates Microglia Activation and Neuroinflammation [PDF]

Frontiers in Pharmacology, 2021
Background: Intervention of neuroinflammation in central nervous system (CNS) represents a potential therapeutic strategy for a host of brain disorders. The scorpion Buthus martensii Karsch (BmK) and its venom have long been used in the Orient to treat inflammation-related diseases such as rhumatoid arthritis and chronic pain.
Xue-Fei Wu, Xue-Fei Wu, Chun Li, Guang Yang, Ying-Zi Wang, Yan Peng, Dan-Dan Zhu, Ao-Ran Sui, Qiong Wu, Qi-Fa Li, Bin Wang, Na Li, Yue Zhang, Bi-Ying Ge, Jie Zhao, Shao Li, Shao Li   +16 more
openaire   +3 more sources

Scorpion Venom: Detriments and Benefits

Biomedicines, 2020
Scorpion venom may cause severe medical complications and untimely death if injected into the human body. Neurotoxins are the main components of scorpion venom that are known to be responsible for the pathological manifestations of envenoming.
Shirin Ahmadi, Julius M. Knerr, Lídia Argemi, Karla C. F. Bordon, Manuela B. Pucca, Felipe A. Cerni, Eliane C. Arantes, Figen Çalışkan, Andreas H. Laustsen   +8 more
doaj   +1 more source