Results 1 to 10 of about 2,790 (169)
Scorpion Venom Peptides: From Structural Scaffolds to Therapeutic Applications—A Focus on Antioxidant Mechanisms and Translational Perspectives [PDF]
AntioxidantsScorpion venom peptides, with their stable disulfide backbone, compact structural framework, and highly selective regulation of ion channels, have long been regarded as important molecular probes in neuropharmacology.
Man Wang +6 more
doaj +2 more sources
Antimicrobial Potential of Scorpion-Venom-Derived Peptides
MoleculesThe frequent and irrational use of antibiotics by humans has led to the escalating rise of antimicrobial resistance (AMR) with a high rate of morbidity-mortality worldwide, which poses a challenge to the development of effective treatments.
Zhiqiang Xia +5 more
doaj +3 more sources
Scorpion Venom Neurotoxins: Molecular Diversity, Mechanisms, and Drug Scaffolds [PDF]
ToxinsVenom is a key evolutionary innovation of venomous organisms in the long-term process of survival adaptation. As one of the oldest arthropods, scorpions produce venom rich in bioactive peptides that also constitute a valuable pharmacological resource ...
Yun Huang +4 more
doaj +2 more sources
Functional evolution of scorpion venom peptides with an inhibitor cystine knot fold [PDF]
Bioscience Reports, 2013 The ICK (inhibitor cystine knot) defines a large superfamily of polypeptides with high structural stability and functional diversity. Here, we describe a new scorpion venom-derived K+ channel toxin (named λ-MeuKTx-1) with an ICK fold through gene ...
Bin Gao +5 more
doaj +6 more sources
Beta Toxins Isolated from the Scorpion Centruroides hirsutipalpus (Scorpiones; Buthidae) Affect the Function of Sodium Channels of Mammals [PDF]
ToxinsScorpion venom toxins are important peptides being studied for their clinical significance. These peptides act by binding to ion channels in the membrane of nerve cells, causing the symptoms associated with scorpion stings (scorpionism). They principally
Laura L. Valdez-Velazquez +8 more
doaj +2 more sources
European Journal of Medicinal Chemistry Reports, 2022 Venom of scorpions is very expensive and lethal, yet with innumerable and exciting potential as a source for the development of biotherapeutics. One of the chief components of scorpion venom is the ‘peptides’ which have shown diverse array of biological ...
R. Suhas
doaj +3 more sources
Microbiota discovered in scorpion venom. [PDF]
PLoS ONEWith low nutrient availability and presence of numerous antimicrobial peptides, animal venoms have been traditionally considered to be harsh sterile environments that lack bacteria.
Barbara Murdoch +3 more
doaj +2 more sources
Pharmacological Research, 2023 Animal venom is an important evolutionary innovation in nature. As one of the most representative animal venoms, scorpion venom contains an extremely diverse set of bioactive peptides.
Zhiqiang Xia +4 more
doaj +1 more source
Antimicrobial Activity Developed by Scorpion Venoms and Its Peptide Component
Toxins, 2022 Microbial infections represent a problem of great importance at the public health level, with a high rate of morbidity-mortality worldwide. However, treating the different diseases generated by microorganisms requires a gradual increase in acquired resistance when applying or using them against various antibiotic therapies.
Clara Andrea Rincón-Cortés +3 more
openaire +4 more sources
SdPI, the first functionally characterized Kunitz-type trypsin inhibitor from scorpion venom. [PDF]
PLoS ONE, 2011 BACKGROUND: Kunitz-type venom peptides have been isolated from a wide variety of venomous animals. They usually have protease inhibitory activity or potassium channel blocking activity, which by virtue of the effects on predator animals are essential for
Ruiming Zhao +9 more
doaj +1 more source