Results 1 to 10 of about 356,030 (194)

Scorpion Venom Neurotoxins: Molecular Diversity, Mechanisms, and Drug Scaffolds [PDF]

Toxins
Venom is a key evolutionary innovation of venomous organisms in the long-term process of survival adaptation. As one of the oldest arthropods, scorpions produce venom rich in bioactive peptides that also constitute a valuable pharmacological resource ...
Yun Huang, Peter Muiruri Kamau, Jiamin Wang, Mingyue Gao, Bowen Li   +4 more
doaj   +3 more sources

Scorpion Venom Peptides: From Structural Scaffolds to Therapeutic Applications—A Focus on Antioxidant Mechanisms and Translational Perspectives [PDF]

Antioxidants
Scorpion venom peptides, with their stable disulfide backbone, compact structural framework, and highly selective regulation of ion channels, have long been regarded as important molecular probes in neuropharmacology.
Man Wang, Haoqi Li, Sheng Li, Yanjie Guo, Yijin Xu, Jie Zhao, Lili Chen   +6 more
doaj   +2 more sources

SdPI, the first functionally characterized Kunitz-type trypsin inhibitor from scorpion venom. [PDF]

PLoS ONE, 2011
BACKGROUND: Kunitz-type venom peptides have been isolated from a wide variety of venomous animals. They usually have protease inhibitory activity or potassium channel blocking activity, which by virtue of the effects on predator animals are essential for
Ruiming Zhao, Hui Dai, Su Qiu, Tian Li, Yawen He, Yibao Ma, Zongyun Chen, Yingliang Wu, Wenxin Li, Zhijian Cao   +9 more
doaj   +2 more sources

Comparative venom gland transcriptome analysis of the scorpion Lychas mucronatus reveals intraspecific toxic gene diversity and new venomous components [PDF]

BMC Genomics, 2010
Background Lychas mucronatus is one scorpion species widely distributed in Southeast Asia and southern China. Anything is hardly known about its venom components, despite the fact that it can often cause human accidents.
Zhijian Cao, Yingliang Wu, Zhiyong Di, Yawen He, Yibao Ma, Ruiming Zhao, Wenxin Li   +6 more
doaj   +2 more sources

Identification and expression analysis of antibacterial peptides from venom of the scorpion Mesobuthus martensii [PDF]

Frontiers in Microbiology
IntroductionAs one kind of important component of animal innate immune system, many antibacterial peptides (ABPs) have been characterized from scorpion venoms.
Gaomin Liu, Jiaqi Xu, Yan Tan, Wenzhen Wang, Hua Ling, Zhijian Cao, Zhifeng Li   +6 more
doaj   +2 more sources

Scorpion venom as a source of new antimicrobial agents [PDF]

Frontiers in Microbiology
The escalating global threat of antimicrobial resistance necessitates urgent discovery of novel therapeutic agents. Scorpion venom, a complex cocktail of bioactive molecules, has emerged as a promising reservoir of antimicrobial peptides (AMPs) with ...
Yuanyuan Zhang, Rongqian Wu
doaj   +2 more sources

Scorpion venom peptides: Molecular diversity, structural characteristics, and therapeutic use from channelopathies to viral infections and cancers

Pharmacological Research, 2023
Animal venom is an important evolutionary innovation in nature. As one of the most representative animal venoms, scorpion venom contains an extremely diverse set of bioactive peptides.
Zhiqiang Xia, Dangui He, Yingliang Wu, Hang Fai Kwok, Zhijian Cao   +4 more
doaj   +1 more source

Mass-Spectrometry-Based Lipidome and Proteome Profiling of Hottentotta saulcyi (Scorpiones: Buthidae) Venom

Toxins, 2022
Scorpion venom is a complex secretory mixture of components with potential biological and physiological properties that attracted many researchers due to promising applications from clinical and pharmacological perspectives.
Parviz Ghezellou, Kevin Jakob, Javad Atashi, Alireza Ghassempour, Bernhard Spengler   +4 more
doaj   +1 more source

Acetylcholinesterase inhibitory potential of scorpion venom in Aedes aegypti (Diptera: Culicidae) [PDF]

Brazilian Journal of Biology, 2022
Scorpion venom contains a variety of neurotoxins which interact with ion channels and affect their activities. The present study was designed to evaluate the potential of scorpion venom as acetylcholinesterase (AChE) inhibitor by using Aedes aegypti as ...
N. Riaz, F. Zubair, N. Amjad, S. Ashraf, S. Asghar, M. Z. Awan, S. Javaid   +6 more
doaj   +1 more source

Transcriptome analysis of the venom gland of the scorpion Scorpiops jendeki: implication for the evolution of the scorpion venom arsenal

BMC Genomics, 2009
Background The family Euscorpiidae, which covers Europe, Asia, Africa, and America, is one of the most widely distributed scorpion groups. However, no studies have been conducted on the venom of a Euscorpiidae species yet.
Wu Yingliang, Liu Jun, Li Songryong, He Yawen, Zhao Ruiming, Ma Yibao, Cao Zhijian, Li Wenxin   +7 more
doaj   +1 more source