Results 51 to 60 of about 2,790 (169)

A Cell‐Penetrating Scorpion Venom Peptide Disrupts the HSP90β‐PPARα Interaction to Ameliorate Metabolic Dysfunction‐Associated Steatotic Liver Disease

iMetaMed, Volume 1, Issue 2, December 2025.
In MASLD, increased HSP90β interacts with PPARα, thereby inhibiting PPARα activation via the inhibition of its nuclear translocation. BmK Tx‐2, a cell‐penetrating peptide from Buthus martensii Karsch scorpion venom, enters hepatocytes via macropinocytosis and escapes endosomes to bind HSP90β.
Erjin Xu, Wuguang Lu, Yonggen Chen, Ming Sang, Jiao Chen, Xueting Cai, Wenhao Xu, Yuxin Zhang, Zhiheng Wang, Feng Zhang, Peng Cao   +10 more
wiley   +1 more source

Mass spectrometry‐based top‐down and bottom‐up approaches for proteomic analysis of the Moroccan Buthus occitanus scorpion venom

FEBS Open Bio, 2021
Buthus occitanus (B. occitanus) is one of the most dangerous scorpions in the world. Despite the involvement of B. occitanus scorpion in severe cases of envenomation in Morocco, no study has focused yet on the proteomic composition of the Moroccan B ...
Khadija Daoudi, Christian Malosse, Ayoub Lafnoune, Bouchra Darkaoui, Salma Chakir, Jean‐Marc Sabatier, Julia Chamot‐Rooke, Rachida Cadi, Naoual Oukkache   +8 more
doaj   +1 more source

Intervertebral Disc Proteoglycans: Multifunctional Tissue Stabilizing and Instructional Cell Regulatory Proteins That Control Tissue Homeostasis

JOR SPINE, Volume 8, Issue 4, December 2025.
Matrix and cell‐associated proteoglycans are important tissue‐stabilizing, weight‐bearing, and tension‐resisting proteins in the intervertebral disc. Their glycosaminoglycan components have growth factor binding and cell‐instructive properties that allow cells to regulate tissue composition and function.
James Melrose
wiley   +1 more source

Structural similarities reveal an expansive conotoxin family with a two‐finger toxin fold

Protein Science, Volume 34, Issue 11, November 2025.
Abstract Venomous animals have evolved a diverse repertoire of toxins with considerable pharmaceutical potential. The rapid evolution of peptide toxins, such as the conotoxins produced by venomous marine cone snails, often complicates efforts to infer their evolutionary relationships based solely on sequence information.
Muhammad Saad Khilji, Celeste M. Hackney, Thomas L. Koch, Arik J. Hone, Aymeric Rogalski, Maren Watkins, Jortan Tun, J. Michael McIntosh, Baldomero Olivera, Helena Safavi‐Hemami, Kaare Teilum, Lars Ellgaard   +11 more
wiley   +1 more source

Antibacterial Activity and Mechanism of a Scorpion Venom Peptide Derivative In Vitro and In Vivo

PLoS ONE, 2012
BmKn2 is an antimicrobial peptide (AMP) characterized from the venom of scorpion Mesobuthus martensii Karsch by our group. In this study, Kn2-7 was derived from BmKn2 to improve the antibacterial activity and decrease hemolytic activity. Kn2-7 showed increased inhibitory activity against both gram-positive bacteria and gram-negative bacteria. Moreover,
Luyang Cao, Chao Dai, Zhongjie Li, Zheng Fan, Yu Song, Yingliang Wu, Zhijian Cao, Wenxin Li   +7 more
openaire   +4 more sources

Unveiling the Evolutionary History of European Vipers and Their Venoms From a Multi‐Omic Approach

Molecular Ecology, Volume 34, Issue 21, November 2025.
ABSTRACT Snake genomes attract significant attention from multiple disciplines, including medicine, drug bioprospection, and evolutionary biology. However, genomic research within the Viperidae family has mostly focused on the subfamily Crotalinae, while the true vipers (Viperinae) have largely been overlooked.
Adrián Talavera, Marc Palmada‐Flores, Fernando Martínez‐Freiría, Gabriel Mochales‐Riaño, Bernat Burriel‐Carranza, Maria Estarellas, Daniel Fernández‐Guiberteau, Álvaro Camina, Sylvain Ursenbacher, Judit Vörös, Bálint Halpern, Davinia Pla, Juan José Calvete, Alexander S. Mikheyev, Tomàs Marquès‐Bonet, Salvador Carranza   +15 more
wiley   +1 more source

Transcriptomic and Proteomic Analyses Reveal the Diversity of Venom Components from the Vaejovid Scorpion Serradigitus gertschi

Toxins, 2018
To understand the diversity of scorpion venom, RNA from venomous glands from a sawfinger scorpion, Serradigitus gertschi, of the family Vaejovidae, was extracted and used for transcriptomic analysis.
Maria Teresa Romero-Gutiérrez, Carlos Eduardo Santibáñez-López, Juana María Jiménez-Vargas, Cesar Vicente Ferreira Batista, Ernesto Ortiz, Lourival Domingos Possani   +5 more
doaj   +1 more source

rBmαTX14 Increases the Life Span and Promotes the Locomotion of Caenorhabditis Elegans. [PDF]

PLoS ONE, 2016
The scorpion has been extensively used in various pharmacological profiles or as food supplies. The exploration of scorpion venom has been reported due to the presence of recombinant peptides. rBmαTX14 is an α-neurotoxin extracted from the venom gland of
Lan Chen, Ju Zhang, Jie Xu, Lu Wan, Kaixuan Teng, Jin Xiang, Rui Zhang, Zebo Huang, Yongmei Liu, Wenhua Li, Xin Liu   +10 more
doaj   +1 more source

Pantinin‐Derived Peptides against Veterinary Herpesviruses: Activity and Structural Characterization

ChemMedChem, Volume 20, Issue 19, October 6, 2025.
Pantinin‐1 and pantinin‐2, scorpion venom–derived peptides, show potent antiviral activity against caprine and bovine herpesviruses. Acting via virucidal action and inhibition of viral entry/fusion, they adopt α‐helical structures in membrane‐mimetic environments. These structure–activity insights highlight their potential as therapeutic agents against
Rosa Giugliano, Carla Zannella, Annalisa Chianese, Clementina Acconcia, Alessandra Monti, Roberta Della Marca, Ugo Pagnini, Serena Montagnaro, Nunzianna Doti, Carla Isernia, Massimiliano Galdiero, Filomena Fiorito, Luigi Russo, Valentina Iovane, Anna De Filippis   +14 more
wiley   +1 more source

A Deeper Examination of Thorellius atrox Scorpion Venom Components with Omic Technologies

Toxins, 2017
This communication reports a further examination of venom gland transcripts and venom composition of the Mexican scorpion Thorellius atrox using RNA-seq and tandem mass spectrometry.
Teresa Romero-Gutierrez, Esteban Peguero-Sanchez, Miguel A. Cevallos, Cesar V. F. Batista, Ernesto Ortiz, Lourival D. Possani   +5 more
doaj   +1 more source