Results 41 to 50 of about 3,366 (180)

Leishmanicidal activity of the venoms of the Scorpions Brotheas amazonicus and Tityus metuendus [PDF]

Brazilian Journal of Biology, 2023
Leishmaniasis is a vector-transmitted zoonosis caused by different species of the genus Leishmania, with a wide clinical spectrum. It is a public health problem aggravated by a series of limitations regarding treatment.
D. B. Pereira, J. G. Martins, M. S. Oliveira, R. S. Lima-Júnior, L. C. Rocha, S. L. Andrade, R. E. L. Procópio   +6 more
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Chaperone-mediated native folding of a β-scorpion toxin in the periplasm of E.coli [PDF]

, 2014
Background: Animal neurotoxin peptides are valuable probes for investigating ion channel structure/function relationships and represent lead compounds for novel therapeutics and insecticides.
Cole, Ambrose R., Lampert, A., Wallace, Bonnie A., O'Reilly, A.O., O’Reilly, A.O., Wallace, B.A., Cole, A.R., Lopes, J.L.S.   +7 more
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Scorpion Toxins and Ion Channels: Potential Applications in Cancer Therapy [PDF]

, 2020
Apoptosis, a genetically directed process of cell death, has been studied for many years, and the biochemical mechanisms that surround it are well known and described.
Mariana S. Castro, Ana Carolina Martins Magalhães, Osmindo Rodrigues Pires, Wagner Fontes, Rosa Amalia Dueñas-Cuellar, Carlos José Correia Santana   +5 more
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Scorpion Venom Causes Apoptosis by Increasing Reactive Oxygen Species and Cell Cycle Arrest in MDA-MB-231 and HCT-8 Cancer Cell Lines

Journal of Evidence-Based Integrative Medicine, 2018
Objectives. The objective of this study was to examine the effect of scorpion venoms on cancer cell progression, apoptosis, and cell cycle arrest. Scorpion venoms are known to possess numerous bioactive compounds that act against cancer progression by ...
Abdulrahman Khazim Al-Asmari PhD, Anvarbatcha Riyasdeen PhD, Mozaffarul Islam PhD   +2 more
doaj   +1 more source

Scorpion venom peptides: Molecular diversity, structural characteristics, and therapeutic use from channelopathies to viral infections and cancers

Pharmacological Research, 2023
Animal venom is an important evolutionary innovation in nature. As one of the most representative animal venoms, scorpion venom contains an extremely diverse set of bioactive peptides.
Zhiqiang Xia, Dangui He, Yingliang Wu, Hang Fai Kwok, Zhijian Cao   +4 more
doaj   +1 more source

A non-lethal method for studying scorpion venom gland transcriptomes, with a review of potentially suitable taxa to which it can be applied.

PLoS ONE, 2021
Scorpion venoms are mixtures of proteins, peptides and small molecular compounds with high specificity for ion channels and are therefore considered to be promising candidates in the venoms-to-drugs pipeline.
Freek J Vonk, Mátyás A Bittenbinder, Harald M I Kerkkamp, Dwin G B Grashof, John P Archer, Sandra Afonso, Michael K Richardson, Jeroen Kool, Arie van der Meijden   +8 more
doaj   +2 more sources

Antigenic and Substrate Preference Differences between Scorpion and Spider Dermonecrotic Toxins, a Comparative Investigation [PDF]

, 2020
The Hemiscorpius lepturus scorpion and brown spider Loxosceles intermedia represent a public health problem in Asia and America, respectively. Although distinct, these organisms contain similar toxins responsible for the principal clinical signs of ...
Liza Felicori, Kamran Pooshang Bagheri, Rafaela Salgado Ferreira, Lucianna Helene Santos, Raoudha Fadhloun, Elham Torabi, Camila F. B. Oliveira, Delavar Shahbazzadeh, Ramla Ben Yekhlef, Lamia Borchani   +9 more
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Characterizing the biological and biochemical profile of six different scorpion venoms from the Buthidae and Scorpionidae family [PDF]

, 2017
Artículo cientificoThe objective of this study was to characterize six different scorpion venoms using biological and biochemical methods, including a preliminary MS/MS and a post-translational modifications analysis.
Van der Meijden, Arie, Lyz Gomez-Rave, Vargas Muñoz, Leidy Johana, Leidy Johana Vargas-Muñoz, Sebastian Estrada-Gómez, Arie van der Meijden, Estrada Gómez, Sebastián, Gómez Rave, Lyz   +7 more
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Scorpion envenomation in Brazil: an update

Infectio, 2021
Accidents caused by scorpions represent a major health problem on planet, both in individual terms and in the public health sphere. Morbid events can occur in different manifestations, and different clinical conditions must be differentiated for adequate
Arthur Fernandes Barbosa Parrela
doaj   +1 more source

Cross-Reactivity and Neutralization Capacity of Polyspecific Antivenom Produced by Razi Institute against Three Species of Buthidea Family Scorpions [PDF]

Asia Pacific Journal of Medical Toxicology, 2019
Background: Scorpion sting is a significant health problem in southern provinces of Iran. Many thousands of people are stung by different species of scorpions annually. More than 60 scorpion species have been reported to be present in Iran. However, Razi
Bahzad Masihipour, Abbas Zare Mirakabadi, mehdi kheirollahpour, Hadi Rabiei, Ali Hedayat   +4 more
doaj   +1 more source