Results 11 to 20 of about 11,109 (115)

Effect of incineration, co-incineration and combustion on TSE hazards in category 1 animal by-products. [PDF]

EFSA J
Abstract The European Commission requested EFSA to assess the effect of incineration, co‐incineration and combustion of Category 1 animal by‐products (ABP) on the BSE/TSE hazards in ash resulting from these treatments. The presence of residual TSE hazards is assessed by detection of prion infectivity or seeding activity.
EFSA Panel on Biological Hazards (BIOHAZ), Allende A, Alvarez-Ordóñez A, Bortolaia V, Bover-Cid S, De Cesare A, Dohmen W, Guillier L, Herman LM, Jacxsens L, Mughini-Gras L, Nauta M, Ottoson J, Peixe L, Perez-Rodriguez F, Skandamis P, Suffredini E, Andreoletti O, Béringue V, Griffin J, Simmons M, Kryemadhi K, Lanfranchi B, Ortiz-Pelaez A, Nonno R.   +24 more
europepmc   +2 more sources

Breaking the Mould: How the First Structure of a Deer Prion Suggests the Framework for Interspecies Strain Diversity and Transmission Barriers. [PDF]

J Neurochem
The normal prion protein (PrPC) fold is shared among mammals; however, it can undergo misfolding in various ways, giving rise to distinct infectious prion (PrPSc) strains. This review describes independent misfolding subdomains within PrP, recognised through new structural alignments and comparisons with the novel deer chronic wasting disease (CWD ...
Manka SW.
europepmc   +2 more sources

Anti-Prion Systems in Saccharomyces cerevisiae. [PDF]

J Neurochem
Yeast pathogenic prions have the same in‐register parallel folded β‐sheet architecture as infectious amyloids of human transmissible spongiform encephalopathy, Alzheimer's disease, Parkinson's disease, and type 2 diabetes. Six anti‐prion systems in yeast (identified by their gene names) together lower the load of prions detected ~5000‐fold by blocking ...
Wickner RB, Hayashi Y, Edskes HK.
europepmc   +2 more sources

Prion Protein Endoproteolysis: Cleavage Sites, Mechanisms and Connections to Prion Disease. [PDF]

J Neurochem
Endoproteolytic cleavage events affect the ability of the cellular prion protein (PrPC) to serve as a substrate for template‐mediated conversion into a misfolded isoform denoted PrPSc, a process integral to the pathogenesis of the fatal neurodegenerative disorders either known as transmissible spongiform encephalopathies or as prion diseases.
Castle AR, Westaway D.
europepmc   +2 more sources

Advances in Single‐Cell Sequencing for Infectious Diseases: Progress and Perspectives

Advanced Science, EarlyView.
Single‐cell sequencing technologies uncover novel, unknown, and emergent features of many diseases. This review describes recent progress of single‐cell sequencing technologies and their applications in infectious diseases, summarizes the underlying commonalities of different infections and discusses future research directions, facilitating the ...
Mengyuan Lyu, Yang Liu, Jian Zhou, Hongli Lai, Hongxia Ruan, Dongsheng Wu, Shun Zhu, Xudong Zhou, Wananqi Ma, Yuchen Huang, Shuting Lei, Han Luo, Jie Chen, Binwu Ying   +13 more
wiley   +1 more source

A Drosophila model of prion disease and its metabolic changes in the brain

Animal Models and Experimental Medicine, EarlyView.
We developed a Drosophila model for prion disease, and flies were capable of expressing the hamster prion protein (HaPrP) under the control of the GAL4/UAS system. The model exhibited some characteristics of the disease in mammals and displayed alterations in protein, sphingolipid, and carbohydrate metabolism. Preliminary applications have demonstrated
Dongdong Wang, Zhixin Sun, Pei Wen, Mengyang Zhao, Yuheng He, Fengting Gou, Jingjing Wang, Qing Fan, Xueyuan Li, Tianying Ma, Xiaoyu Wang, Wen Li, Sen Chen, Deming Zhao, Lifeng Yang   +14 more
wiley   +1 more source

Physics of Protein Aggregation in Normal and Accelerated Brain Aging

BioEssays, EarlyView.
Soluble monomeric proteins precipitate via nucleation into insoluble amyloids in response to age‐related exposures (e.g., microbes, nanoparticles). Persistent soluble‐to‐insoluble phase transition depletes the functional proteins. In normal aging, replacement matches loss; in accelerated aging, it does not.
Alberto J. Espay, Andrea Sturchio, Alberto Imarisio, Emily J. Hill, Brady Williamson, Kora Montemagno, Christian Hoffmann, Hugo Le Roy, Dragomir Milovanovic, Fredric P. Manfredsson   +9 more
wiley   +1 more source

Lessons learned and lingering uncertainties after seven years of chronic wasting disease management in Norway

Wildlife Biology, EarlyView.
Chronic wasting disease (CWD) is well known among cervids in North America. Nevertheless, management faced different types and degrees of uncertainty when CWD was first detected in reindeer Rangifer tarandus in Nordfjella, Norway in 2016. We present a timeline of the efforts to control CWD, and identify how the process, measurement, environmental, and ...
Atle Mysterud, Michael A. Tranulis, Olav Strand, Christer M. Rolandsen   +3 more
wiley   +1 more source

Optimising the Use of Cryopreserved Genetic Resources for the Selection and Conservation of Animal Populations

Journal of Animal Breeding and Genetics, EarlyView.
ABSTRACT Genetic diversity is essential for the sustainability and adaptability of populations, and is thus a central pillar of the agro‐ecological transition. However, within a population, it is inevitable that some amount of genetic variability is lost, and efforts must be made to limit this as much as possible.
Alicia Jacques, Michèle Tixier‐Boichard, Gwendal Restoux   +2 more
wiley   +1 more source

Comparison of Dysautonomia Across Species: Current Knowledge and Future Research Opportunities

Journal of Veterinary Internal Medicine, Volume 39, Issue 4, July/August 2025.
ABSTRACT Primary dysautonomia is a complex and often fatal autonomic nervous system disease. This literature review consolidates information on dysautonomia across species. Electronic databases (PubMed, Google Scholar and the Equine Grass Sickness Fund website) were systematically searched for veterinary and human medical literature on the topic.
Callum N. Atkins, Caroline N. Hahn, Bruce C. McGorum   +2 more
wiley   +1 more source