Results 121 to 130 of about 6,568,873 (280)
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande +11 more
wiley +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Effect of coffee (caffeine) against human cataract blindness
Clinical Ophthalmology, 2016 Shambhu D VarmaDepartment of Ophthalmology and Visual Sciences, Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, USAAbstract: Previous biochemical and morphological studies with animal experiments have ...
Varma SD
doaj
, 2022 Zu Beginn des Zweiten Weltkriegs legte der »Reichsführer SS« Heinrich Himmler den Sicherheitsdienst und die Sicherheitspolizei zum Reichssicherheitshauptamt (RSHA) zusammen, es war eines der »Hauptämter« der SS. Leiter war Reinhard Heydrich, nach dessen Tod 1941 und einer halbjährigen Leitung durch Himmler übernahm der Österreicher Ernst Kaltenbrunner ...
Straub, Wolfgang +2 more
openaire +1 more source
Screening for lung cancer: A systematic review of overdiagnosis and its implications
Molecular Oncology, EarlyView.Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece +18 more
wiley +1 more source
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
Effects of GnRH and PGF2 Injection on Progesterone Profile of Postpartum Dairy Cow
Animal Production: Indonesian Journal of Animal Production, 2008 A research of progesterone profile on postpartum dairy cows after GnRH and PGF2a treatment had been conducted to determine the skim milk progesterone profiles, which enhance ovarian activity in postpartum dairy cows.
SD Rasad
doaj
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source