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Reaper is regulated by IAP-mediated ubiquitination [PDF]

, 2003
In most cases, apoptotic cell death culminates in the activation of the caspase family of cysteine proteases, leading to the orderly dismantling and elimination of the cell.
Hay, Bruce A. +5 more
core

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura +2 more
wiley +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar +4 more
wiley +1 more source

Identificación de proteínas extrínsecas en jamones cocidos por SDS-PAGE: Nivel de detección en sistemas modelo</a> </p><span class="r_subtitle"><img src="/img/openaccess.ico" alt="open access: yes" title="open access: yes" width="16" height="16"><i>Archivos Latinoamericanos de Nutrición</i>, 2006 </span><br><span class="r_content">El Código Alimentario Argentino establece que el jamón cocido, la paleta cocida y el lomo de cerdo cocido no pueden contener proteínas agregadas ni otros extensores, permitiendo el agregado de proteínas de soja según el límite para chacinados (2% de ...</span><br><span class="r_sub"><i>Laura Beatríz López<span id="ma_4" style="display:none">, Carola Beatríz Greco, Patricia Ronayne de Ferrer, Mirta Eva Valencia</span> <small><a href="#" style="color:#808080;" onClick="return toggle_div(this, 'ma_4')">+3 more</a></small></i></span><br><small><a href="https://doaj.org/article/79ce2b201b544b1db39dfd56c846699e" target="_blank" rel="nofollow" title="doaj.org/article/79ce2b201b544b1db39dfd56c846699e">doaj</a> </small> <br></div><div class="r"><p class="r_title"><a href="https://doi.org/10.1002/acn3.70272" target="_blank" rel="nofollow">Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease</a> </p><span class="r_subtitle"><img src="/img/openaccess.ico" alt="open access: yes" title="open access: yes" width="16" height="16"><i>Annals of Clinical and Translational Neurology, EarlyView.</i></span><br><span class="r_content">ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and </span><br><span class="r_sub"><i>Daniel Chelsky<span id="ma_5" style="display:none">, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen</span> <small><a href="#" style="color:#808080;" onClick="return toggle_div(this, 'ma_5')">+8 more</a></small></i></span><br><small><a href="https://onlinelibrary.wiley.com/doi/10.1002/acn3.70272?mi=2or9o2m&af=R&AllField=sds-page&ConceptID=15941&content=articlesChapters&target=default" target="_blank" rel="nofollow" title="wiley.com/doi/10.1002/acn3.70272?mi=2or9o2m&af=R&AllField=sds-page&ConceptID=15941&content=articlesChapters&target=default">wiley</a> </small> <div id="more_5" style="display:none"><a href="/sci_redir.php?doi=10.1002%2Facn3.70272" target="_blank" rel="nofollow">openaccessbutton.org (pdf)</a><br><a href="javascript:navigator.clipboard.writeText('10.1002/acn3.70272'); alert('Copied the doi');">copy doi</a> <small>(10.1002/acn3.70272)</small><br></div><small><a href="#" onClick="return toggle_div(this, 'more_5')">+1 more source</a></small><br></div><div class="r"><p class="r_title"><a href="https://doi.org/10.1002/acn3.70372" target="_blank" rel="nofollow">ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression</a> </p><span class="r_subtitle"><img src="/img/openaccess.ico" alt="open access: yes" title="open access: yes" width="16" height="16"><i>Annals of Clinical and Translational Neurology, EarlyView.</i></span><br><span class="r_content">ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.</span><br><span class="r_sub"><i>Kaixin Yan<span id="ma_6" style="display:none">, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu</span> <small><a href="#" style="color:#808080;" onClick="return toggle_div(this, 'ma_6')">+9 more</a></small></i></span><br><small><a href="https://onlinelibrary.wiley.com/doi/10.1002/acn3.70372?mi=2or9o2m&af=R&AllField=sds-page&ConceptID=15941&content=articlesChapters&target=default" target="_blank" rel="nofollow" title="wiley.com/doi/10.1002/acn3.70372?mi=2or9o2m&af=R&AllField=sds-page&ConceptID=15941&content=articlesChapters&target=default">wiley</a> </small> <div id="more_6" style="display:none"><a href="/sci_redir.php?doi=10.1002%2Facn3.70372" target="_blank" rel="nofollow">openaccessbutton.org (pdf)</a><br><a href="javascript:navigator.clipboard.writeText('10.1002/acn3.70372'); alert('Copied the doi');">copy doi</a> <small>(10.1002/acn3.70372)</small><br></div><small><a href="#" onClick="return toggle_div(this, 'more_6')">+1 more source</a></small><br></div><div class="r"><p class="r_title"><a href="https://explore.openaire.eu/search/publication?articleId=jairo_______%3A%3A4d07298ff89378eb46ff71b3993ecab0" target="_blank" rel="nofollow">SDS-PAGE</a> </p><span class="r_subtitle"><img src="/img/openaccess.ico" alt="open access: yes" title="open access: yes" width="16" height="16"><i>SDS-PAGE</i></span><br><span class="r_content">3章単離・精製・活性測定 6. タンパク質 a 調製した生体試料のタンパク質組成を解析する際などに，最初に行われる最も基礎的な実験のひとつがSDS-PAGEであろう．近年のプロテオミクス解析に於いて広く用いられる等電点二次元電気泳動でも，二次元目にはSDS-PAGEが行われるのが一般的である．比較的容易に行うことができるSDS-PAGEであるが，手元の生体試料に含まれているタンパク質群の中にある重要なタンパク質を見落とさないために留意しておくと良いことがある．本稿では，4種類のSDS-PAGE系を比較しながら，それぞれの実験方法を簡単に記述する． SDS-PAGE is one of the very basic techniques for the protein analysis.</span><br><small><a href="https://explore.openaire.eu/search/publication?articleId=jairo_______%3A%3A4d07298ff89378eb46ff71b3993ecab0" target="_blank" rel="nofollow" title="openaire.eu/search/publication?articleId=jairo_______%3A%3A4d07298ff89378eb46ff71b3993ecab0">openaire</a> </small> <br></div><div class="r"><p class="r_title"><a href="https://doi.org/10.17504/protocols.io.erpbd5n" target="_blank" rel="nofollow">SDS-PAGE Cracking Buffer v1</a> </p><span class="r_subtitle"><img src="/img/openaccess.ico" alt="open access: yes" title="open access: yes" width="16" height="16">, 2016 </span><br><span class="r_content">Recipe to make 10ml of 2x stock </span><br><small><a href="https://explore.openaire.eu/search/publication?pid=10.17504%2Fprotocols.io.erpbd5n" target="_blank" rel="nofollow" title="openaire.eu/search/publication?pid=10.17504%2Fprotocols.io.erpbd5n">openaire</a> </small> <div id="more_8" style="display:none"><a href="/sci_redir.php?doi=10.17504%2Fprotocols.io.erpbd5n" target="_blank" rel="nofollow">openaccessbutton.org (pdf)</a><br><a href="javascript:navigator.clipboard.writeText('10.17504/protocols.io.erpbd5n'); alert('Copied the doi');">copy doi</a> <small>(10.17504/protocols.io.erpbd5n)</small><br></div><small><a href="#" onClick="return toggle_div(this, 'more_8')">+1 more source</a></small><br></div><div class="r"><p class="r_title"><a href="https://doi.org/10.1002/acn3.70384" target="_blank" rel="nofollow">A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility</a> </p><span class="r_subtitle"><img src="/img/openaccess.ico" alt="open access: yes" title="open access: yes" width="16" height="16"><i>Annals of Clinical and Translational Neurology, EarlyView.</i></span><br><span class="r_content">ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.</span><br><span class="r_sub"><i>Manuela Amaral‐do‐Nascimento<span id="ma_9" style="display:none">, Daniela F. Santos, Tuane C. R. G. Vieira, Tiago F. Outeiro</span> <small><a href="#" style="color:#808080;" onClick="return toggle_div(this, 'ma_9')">+3 more</a></small></i></span><br><small><a href="https://onlinelibrary.wiley.com/doi/10.1002/acn3.70384?mi=2or9o2m&af=R&AllField=sds-page&ConceptID=15941&content=articlesChapters&target=default" target="_blank" rel="nofollow" title="wiley.com/doi/10.1002/acn3.70384?mi=2or9o2m&af=R&AllField=sds-page&ConceptID=15941&content=articlesChapters&target=default">wiley</a> </small> <div id="more_9" style="display:none"><a href="/sci_redir.php?doi=10.1002%2Facn3.70384" target="_blank" rel="nofollow">openaccessbutton.org (pdf)</a><br><a href="javascript:navigator.clipboard.writeText('10.1002/acn3.70384'); alert('Copied the doi');">copy doi</a> <small>(10.1002/acn3.70384)</small><br></div><small><a href="#" onClick="return toggle_div(this, 'more_9')">+1 more source</a></small><br></div><div class="r"><p class="r_title"><a href="https://doi.org/10.1002/acr.70016" target="_blank" rel="nofollow">Evaluation of a Novel Electric Health Record Sidecar Application to Display Rheumatoid Arthritis Clinical Outcomes During Clinic Visits: Results of a Stepped‐Wedge Cluster Randomized Pragmatic Trial</a> </p><span class="r_subtitle"><img src="/img/openaccess.ico" alt="open access: yes" title="open access: yes" width="16" height="16"><i>Arthritis Care &Research, EarlyView.</i></span><br><span class="r_content">Objective We developed a novel electronic health record sidecar application to visualize key rheumatoid arthritis (RA) outcomes, including disease activity, physical function, and pain, via a patient‐facing graphical interface designed for use during outpatient visits (“RA PRO dashboard”).</span><br><span class="r_sub"><i>Gabriela Schmajuk<span id="ma_10" style="display:none">, Jing Li, Cathy Nasrallah, Cherish Wilson, Alicia Hamblin, Christine Hariz, Cammie Young, Stephen Shiboski, Emma Kersey, Mary Nakamura, Judith F. Ashouri, Mehrdad Matloubian, Andrew J. Gross, Jennifer Barton, Beth Berrean, Jonathan Prugh, Jinoos Yazdany</span> <small><a href="#" style="color:#808080;" onClick="return toggle_div(this, 'ma_10')">+16 more</a></small></i></span><br><small><a href="https://onlinelibrary.wiley.com/doi/10.1002/acr.70016?mi=2or9o2m&af=R&AllField=sds-page&ConceptID=15941&content=articlesChapters&target=default" target="_blank" rel="nofollow" title="wiley.com/doi/10.1002/acr.70016?mi=2or9o2m&af=R&AllField=sds-page&ConceptID=15941&content=articlesChapters&target=default">wiley</a> </small> <div id="more_10" style="display:none"><a href="/sci_redir.php?doi=10.1002%2Facr.70016" target="_blank" rel="nofollow">openaccessbutton.org (pdf)</a><br><a href="javascript:navigator.clipboard.writeText('10.1002/acr.70016'); alert('Copied the doi');">copy doi</a> <small>(10.1002/acr.70016)</small><br></div><small><a href="#" onClick="return toggle_div(this, 'more_10')">+1 more source</a></small><br></div><div class="r"><div style="margin-bottom:2px;overflow:hidden"><div style="display: inline-block; float: left; font-size: small; padding-right: 16px; margin-top: -1px; padding-bottom: 1px;"><a href="/q-proteins/" class="suggestion"onclick="show_loader();"><b>proteins</b></a><br/><a href="/q-electrophoresis%2C_polyacrylamide_gel/" class="suggestion"onclick="show_loader();"><b>electrophoresis, polyacrylamide gel</b></a><br/><a href="/q-3._good_health/" class="suggestion"onclick="show_loader();"><b>3. good health</b></a><br/></div><div style="display: inline-block; float: left; font-size: small; padding-right: 16px; margin-top: -1px; padding-bottom: 1px;"><a href="/q-electrophoresis/" class="suggestion"onclick="show_loader();"><b>electrophoresis</b></a><br/><a href="/q-glycine/" class="suggestion"onclick="show_loader();"><b>glycine</b></a><br/><a href="/q-biology_general/" class="suggestion"onclick="show_loader();"><b>biology general</b></a><br/></div><div style="display: inline-block; float: left; font-size: small; padding-right: 16px; margin-top: -1px; padding-bottom: 1px;"><a href="/q-protein/" class="suggestion"onclick="show_loader();"><b>protein</b></a><br/></div></div></div><div class="pagenav"><a href="/q-sds-page/p-16/" rel="nofollow"><b>previous</b></a> <a href="/q-sds-page/p-15/" rel="nofollow">15</a> <a href="/q-sds-page/p-16/" rel="nofollow">16</a> <b>17</b> <a href="/q-sds-page/p-18/" rel="nofollow">18</a> <a href="/q-sds-page/p-19/" rel="nofollow">19</a> <a href="/q-sds-page/p-18/" id="next" rel="nofollow"><b>next</b></a> </div><br></div> </div> <script>document.getElementById('loadingGif').style.display='none';</script><div style="width: 100%; height: 40px; bottom: 0px; background-color: #f5f5f5;"><div style="padding-left: 15px; padding-top: 10px"> <a href="/" rel="nofollow">Home</a> - <a href="/page-about/" rel="nofollow">About</a> - <a href="/page-disclaimer/" rel="nofollow">Disclaimer</a> - <a href="/page-privacy/" rel="nofollow">Privacy</a> </div></div> <link rel="stylesheet" href="//ajax.googleapis.com/ajax/libs/jqueryui/1.11.4/themes/smoothness/jquery-ui.min.css"/> </body> </html>