Results 71 to 80 of about 136,579 (306)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

The sensitivity of sea-ice brine fraction to the freezing temperature and orientation

Annals of Glaciology
The changing conditions in which sea ice forms and exists are likely to affect the properties of sea ice itself, and potential climate feedbacks need to be identified and understood to improve future projections.
Kial Douglas Stewart, William Palm, Callum James Shakespeare, Noa Kraitzman   +3 more
doaj   +1 more source

ICESHEET 1.0: a program to produce paleo-ice sheet reconstructions with minimal assumptions [PDF]

Geoscientific Model Development, 2016
We describe a program that produces paleo-ice sheet reconstructions using an assumption of steady-state, perfectly plastic ice flow behaviour. It incorporates three input parameters: ice margin, basal shear stress and basal topography.
E. J. Gowan, P. Tregoning, A. Purcell, J. Lea, O. J. Fransner, R. Noormets, J. A. Dowdeswell   +6 more
doaj   +1 more source

The Finite Element Sea Ice-Ocean Model (FESOM) v.1.4: formulation of an ocean general circulation model [PDF]

, 2014
The Finite Element Sea Ice-Ocean Model (FESOM) is the first global ocean general circulation model based on unstructured-mesh methods that has been developed for the purpose of climate research.
C. Wekerle, D. Sidorenko, J. Schröter, Q. Wang, R. Timmermann, S. Danilov, T. Jung, X. Wang   +7 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

High-resolution regional sea-ice model based on the discrete element method with boundary conditions from a large-scale model for ice drift

Annals of Glaciology
Understanding sea-ice dynamics at the floe scale is crucial to comprehend polar climate systems. While continuum models are commonly used to simulate large-scale sea-ice dynamics, they have limitations in accurately representing sea-ice behaviour at ...
Andrei Tsarau, Wenjun Lu, Raed Lubbad, Sveinung Løset, Yuan Zhang   +4 more
doaj   +1 more source

Estimating Arctic Sea Ice Thickness with CryoSat-2 Altimetry Data Using the Least Squares Adjustment Method

Sensors, 2020
Satellite altimeters can be used to derive long-term and large-scale sea ice thickness changes. Sea ice thickness retrieval is based on measurements of freeboard, and the conversion of freeboard to thickness requires knowledge of the snow depth and snow,
Feng Xiao, Fei Li, Shengkai Zhang, Jiaxing Li, Tong Geng, Yue Xuan   +5 more
doaj   +1 more source

Comparing sea ice, hydrography and circulation between NEMO3.6 LIM3 and LIM2 [PDF]

Geoscientific Model Development, 2017
A set of hindcast simulations with the new version 3.6 of the Nucleus for European Modelling of the Ocean (NEMO) ocean–ice model in the ORCA1 configuration and forced by the DRAKKAR Forcing Set version 5.2 (DFS5.2) atmospheric data was performed from ...
P. Uotila, D. Iovino, M. Vancoppenolle, M. Lensu, C. Rousset   +4 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Antarctic ice sheet discharge driven by atmosphere-ocean feedbacks at the Last Glacial Termination [PDF]

, 2016
Reconstructing the dynamic response of the Antarctic ice sheets to warming during the Last Glacial Termination (LGT; 18,000–11,650 yrs ago) allows us to disentangle ice-climate feedbacks that are key to improving future projections.
Baker, A., Bird, M.I., Cooper, A., Curran, M.A.J., Davies, S.M., Ellis, B., Etheridge, D.M., Fogwill, C.J., Golledge, N.R., Menviel, L., Millman, H., Moy, A.D., Munksgaard, N.C., Rivera, A., Rootes, C.M., Rubino, M., Thornton, D.P., Turney, C.S.M., van Ommen, T.D., Vohra, J., Weber, M.E., Winter, K., Woodward, J.   +22 more
core   +3 more sources