Results 121 to 130 of about 403,562 (281)

The mechanism linking the variability of the Antarctic sea ice extent in the Indian Ocean sector to Indian summer monsoon rainfall. [PDF]

Clim Dyn, 2023
Azhar SSA, Chenoli SN, Samah AA, Kim SJ, Murukesh N.   +4 more
europepmc   +1 more source

Sea Ice Prediction Has Easy and Difficult Years [PDF]

, 2014
Arctic sea ice follows an annual cycle, reaching its low point in September each year. The extent of sea ice remaining at this low point has been trending downwards for decades as the Arctic warms.
Bitz, Cecilia M., Blanchard-Wrigglesworth, Edward, Cutler, Matthew, Hamilton, Lawrence C., Kay, Jennifer, Meier, Walter N., Stroeve, Julienne, Wiggins, Helen   +7 more
core   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Ice type matters: impacts of landfast and drift ice on body condition in a high Arctic seabird community

Frontiers in Marine Science
Sea ice, a central component of polar ecosystems, is undergoing profound changes due to climate change. In particular, the Arctic is experiencing unprecedented warming at quicker rates than other regions.
Christophe Sauser, Pierre Blévin, Olivier Chastel, Geir Wing Gabrielsen, Sveinn Are Hanssen, Erlend Lorentzen, Børge Moe, Sebastien Moreau, Kjetil Sagerup, Sebastien Descamps   +9 more
doaj   +1 more source

Decline in plankton diversity and carbon flux with reduced sea ice extent along the Western Antarctic Peninsula. [PDF]

Nat Commun, 2021
Lin Y, Moreno C, Marchetti A, Ducklow H, Schofield O, Delage E, Meredith M, Li Z, Eveillard D, Chaffron S, Cassar N.   +10 more
europepmc   +1 more source

Dynamic Preconditioning of the Minimum September Sea-Ice Extent

Journal of Climate, 2016
Abstract There has been an increased interest in seasonal forecasting of the Arctic sea ice extent in recent years, in particular the minimum sea ice extent. Here, a dynamical mechanism, based on winter preconditioning, is found to explain a significant fraction of the variance in the anomaly of the September sea ice extent from the long-
Bruno Tremblay, James Williams, Robert Newton, Richard Allard   +3 more
openaire   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Validation of the Satellite-Based Landfast Ice Mapping [PDF]

, 2011
Landfast sea ice is distinctive feature of Arctic and Antarctic coastal zones. It is contiguous with the shore and relatively immobile ice cover that has fastened along the coast or to the sea floor.
Selyuzhenok, Valeria
core