Results 101 to 110 of about 1,896 (179)

Lingering challenges in malaria elimination efforts in sub‐Saharan Africa: Insights and potential solutions

Health Science Reports, Volume 7, Issue 6, June 2024.
Abstract Introduction Between 2000 and 2015, significant gains were recorded in reducing the global burden of malaria due to enhanced global collaboration and increased funding. However, progress has stagnated post‐2015, and the COVID‐19 pandemic seems to have reversed some of these gains, necessitating a critical reevaluation of interventions.
Lukman Lawal, Ahmad Oyindamola Buhari, Tawakalitu Abdulateef Jaji, Abdulrahman Salaudeen Alatare, Abdulmalik Opeyemi Adeyemo, Aishat Oluwakemi Olumoh, Yusuff Adesoji Yusuff, Gabriel Osborn, Abdulazeez Biodun Mogaji, Bello Hussein Adoto, Nafisa Gbemisola Ibrahim, Waliyullahi Oluwafemi Saliu, Toufik Abdul‐Rahman   +12 more
wiley   +1 more source

Seasonal Malaria Chemoprevention Coverage Survey Guinea, 2018

, 2019
The 2018 SMC coverage survey in Guinea was conducted by the University Gamal Abdel Nasser, Conakry and the London School of Hygiene & Tropical Medicine, in collaboration with the National Malaria Control Programme and Catholic Relief Services ...
Loua, Kovana Marcel, Milligan, Paul
openaire   +2 more sources

Medication adherence framework: A population‐based pharmacokinetic approach and its application in antimalarial treatment assessments

CPT: Pharmacometrics &Systems Pharmacology, Volume 13, Issue 5, Page 795-811, May 2024.
Abstract We reported here on the development of a pharmacometric framework to assess patient adherence, by using two population‐based approaches – the percentile and the Bayesian method. Three different dosing strategies were investigated in patients prescribed a total of three doses; (1) non‐observed therapy, (2) directly observed administration of ...
Junjie Ding, Richard M. Hoglund, Joel Tarning   +2 more
wiley   +1 more source

Is it time for Africa to adopt primaquine in the era of malaria control and elimination?

Tropical Medicine and Health, 2022
Keypoints Sub-Saharan Africa contributes about 95% of global malaria cases and related deaths. Despite safety concerns adoption of SLD primaquine is needed to further reduce malaria transmission, an essential prerequisite for the elimination of the ...
Richard O. Mwaiswelo, Hamis Kabuga, Eliningaya J. Kweka, Vito Baraka   +3 more
doaj   +1 more source

Estimation of trajectory of protective efficacy in infectious disease prevention trials using recurrent event times

Statistics in Medicine, Volume 43, Issue 9, Page 1759-1773, 30 April 2024.
In studies of infectious disease prevention, the level of protective efficacy of medicinal products such as vaccines and prophylactic drugs tends to vary over time. Many products require administration of multiple doses at scheduled times, as opposed to one‐off or continual intervention. Accurate information on the trajectory of the level of protective
Yin Bun Cheung, Xiangmei Ma, K. F. Lam, Chee Fu Yung, Paul Milligan   +4 more
wiley   +1 more source

Malaria Prevention Strategies in South Sudan

South Sudan Medical Journal, 2020
The whole of South Sudan is endemic for malaria, with high transmission in the country throughout the year. Malaria is the leading cause of illness and death in children under five years. In 2019, the malaria incidence (all ages) was estimated at 246 per
Harriet Akello Pasquale
doaj  

Assessment of the Feasibility, Acceptability, and Impact of Implementing Seasonal Malaria Chemoprevention in Nampula Province, Mozambique: Protocol for a Hybrid Effectiveness-Implementation Study (Preprint) [PDF]

, 2021
Alexandra Wharton–Smith, K. Scott Baker, Arantxa Roca‐Feltrer, Maria Rodrigues, Sol Richardson, Craig Bonnington, Christian Rassi, Madeleine Marasciulo, Sónia Enosse, Francisco Saúte, Pedro Aíde, Eusébio Macete, Baltazar Candrinho   +12 more
openalex   +1 more source

Randomized, placebo‐controlled, double‐blind phase I trial of co‐administered pyronaridine and piperaquine in healthy adults of sub‐Saharan origin

Clinical and Translational Science, Volume 17, Issue 4, April 2024.
Abstract Drug resistance to sulfadoxine‐pyrimethamine and amodiaquine threatens the efficacy of malaria chemoprevention interventions in children and pregnant women. Combining pyronaridine (PYR) and piperaquine (PQP), both components of approved antimalarial therapies, has the potential to protect vulnerable populations from severe malaria.
Andrea Kuemmerle, Denis Gossen, Annick Janin, Andrew Stokes, Nada Abla, Maja Szramowska, Ulrike Lorch, Myriam El Gaaloul, Isabelle Borghini‐Fuhrer, Stephan Chalon   +9 more
wiley   +1 more source

Beninese Plant Extracts with Antiplasmodial Activity Select New Allele Variants Msp1 and Msp2 in Plasmodium falciparum

Journal of Parasitology Research, Volume 2024, Issue 1, 2024.
Background. Natural medicinal products are commonly used as a remedy against malaria infections in African populations and have become a major source of information for the screening of new and more effective antiplasmodial molecules. Therefore, in vitro studies are needed to validate the efficacy of these medicinal products and to explore the ...
Hamirath O. Lagnika, Adandé A. Medjigbodo, Oswald Y. Djihinto, Helga M. Saïzonou, Wassiyath A. Mousse, Romaric Akoton, Laurette Djossou, Doris N. Vodounkpe, Latifou Lagnika, Luc S. Djogbénou, Bernard Marchand   +10 more
wiley   +1 more source

Risk of Plasmodium falciparum infection in south-west Burkina Faso: potential impact of expanding eligibility for seasonal malaria chemoprevention [PDF]

, 2022
Jean Baptiste Yaro, Alfred B. Tiono, Alphonse Ouédraogo, Ben Lambert, Z Amidou Ouedraogo, Amidou Diarra, Adama Traoré, Malik Lankouande, Issiaka Soulama, Antoine Sanou, Eve Worrall, Efundem Agboraw, N’Falé Sagnon, Hilary Ranson, Thomas S. Churcher, Steve W. Lindsay, Anne L. Wilson   +16 more
openalex   +1 more source