Evaluation of seasonal malaria chemoprevention implementation in the Upper East region of Northern Ghana. [PDF]
Ghana adopted the WHO-recommended Seasonal Malaria Chemoprevention (SMC) in 2016 following a pilot study as a vital strategy for malaria control. SMC is the intermittent administration of a preventive and curative dose of anti-malarial medicine (Sulfadoxine-Pyrimetamine + Amodiaquine) during four months of the malaria season.
Ayamba EY+8 more
europepmc +5 more sources
Seasonal Malaria Vaccination with or without Seasonal Malaria Chemoprevention [PDF]
Malaria control remains a challenge in many parts of the Sahel and sub-Sahel regions of Africa.We conducted an individually randomized, controlled trial to assess whether seasonal vaccination with RTS,S/AS01E was noninferior to chemoprevention in preventing uncomplicated malaria and whether the two interventions combined were superior to either one ...
Daniel Chandramohan+29 more
openalex +5 more sources
Evaluating the effectiveness and cost-effectiveness of integrating mass drug administration for helminth control with seasonal malaria chemoprevention in Ghanaian children: Protocol for a cluster randomised controlled trial. [PDF]
Abstract Objectives To evaluate the effectiveness and cost‐effectiveness of integrating seasonal malaria chemoprevention (SMC) with mass drug administration for helminth control among school‐aged children living in communities where the burden of malaria and helminths is high in Ghana, West Africa.
Afolabi MO+6 more
europepmc +3 more sources
Predictors of caregiver adherence to administration of amodiaquine during delivery of seasonal malaria chemoprevention in Nigeria, Burkina Faso, Chad, and Togo [PDF]
Background Malaria is the leading cause of morbidity and mortality among infants and children under-five in sub-Saharan Africa. In the Sahel, seasonal malaria chemoprevention (SMC) is delivered door-to-door in monthly cycles.
Taiwo Ibinaiye+6 more
doaj +2 more sources
Evidence that seasonal malaria chemoprevention with SPAQ influences blood and pre-erythrocytic stage antibody responses of Plasmodium falciparum infections in Niger [PDF]
Background In endemic areas, children develop slowly and naturally anti-Plasmodium antibodies and become semi-immune. Seasonal Malaria Chemoprevention (SMC) with sulfadoxine-pyrimethamine + amodiaquine (SPAQ) is a new strategy to reduce malaria morbidity
Lamine Mahaman Moustapha+7 more
doaj +2 more sources
Cost-effectiveness of seasonal malaria chemoprevention in upper west region of Ghana [PDF]
In Ghana, malaria is endemic and perennial (with significant seasonal variations in the three Northern Regions), accounting for 33 % of all deaths among children under 5 years old, with prevalence rates in children under-five ranging from 11 % in Greater Accra to 40 % in Northern Region.
Justice Nonvignon+8 more
openalex +4 more sources
Systematic review on the cost of seasonal malaria chemoprevention (SMC). [PDF]
Implemented in 17 countries to date, seasonal malaria chemoprevention (SMC) is a recommended strategy to prevent childhood malaria in areas with seasonal transmission of P. falciparum through monthly administration of antimalarial medicines. Understanding the costs and resource requirements of SMC delivery is necessary for effective planning and ...
Ruisch A+7 more
europepmc +4 more sources
Seasonal Malaria Chemoprevention: An Evolving Research Paradigm. [PDF]
Robert W. Snow discusses the importance of empirical evidence, such as that provided in the trial published this week by Milligan and colleagues, in guiding malaria control in Africa.
Robert W Snow
doaj +4 more sources
Seasonal malaria chemoprevention (SMC) is a new strategy recommended by WHO in areas of highly seasonal transmission in March 2012. Although randomized controlled trials (RCTs) have shown SMC to be highly effective, evidence and experience from routine implementation of SMC are limited.A non-randomized pragmatic trial with pre-post design was used ...
Fatou Diawara+14 more
openalex +6 more sources
Seasonal malaria chemoprevention in Africa and China's upgraded role as a contributor: a scoping review. [PDF]
Abstract Background Children under five are the vulnerable population most at risk of being infected with Plasmodium parasites, especially in the Sahel region. Seasonal malaria chemoprevention (SMC) recommended by World Health Organization (WHO), has proven to be a highly effective intervention to prevent malaria.
Xu M+10 more
europepmc +4 more sources