Results 81 to 90 of about 1,896 (179)

Effectiveness of seasonal malaria chemoprevention in reducing under-five malaria morbidity and mortality in the Savannah Region, Ghana

Ghana Medical Journal, 2022
Objective: To assess the effectiveness of seasonal malaria chemoprevention (SMC) in reducing under-five malaria morbidity and mortalityDesign: Under-five malaria data for confirmed episodes, deaths, and number of children dosed per cycle of SMC campaign were extracted from the District Health Information Management System (DHIMS-2) for 2018-2019.
R Adjei, Michael, Kubio, Chrysantus, Buamah, Marcel, Sarfo, Adjei, Suuri, Thomas, Ibrahim, Saeed, Sadiq, Abubakari, I Abubakari, Ihsan, V Baafi, Janet   +8 more
openaire   +3 more sources

Gametocyte carriage after seasonal malaria chemoprevention in Plasmodium falciparum infected asymptomatic children [PDF]

Malaria Journal, 2020
Abstract Background Treatment of clinical Plasmodium falciparum malaria with sulfadoxine-pyrimethamine (SP) and amodiaquine (AQ) is associated with increased post-treatment gametocyte carriage. The effect of seasonal malaria chemoprevention (SMC) with SP and AQ on gametocyte carriage was assessed in asymptomatic P ...
Abdullahi Ahmad, Abdullahi Ahmad, Mamadou Ousmane Ndiath, John S. Bradley, Jean-Pierre Van Geertruyden, Teun Bousema, Jane Achan, Mamadou Bah, Aurelia Prom, Umberto D'Alessandro, Blessed Etoketim, Chris Drakeley   +11 more
openaire   +8 more sources

Use of population pharmacokinetic‐pharmacodynamic modelling to inform antimalarial dose optimization in infants

British Journal of Clinical Pharmacology, Volume 91, Issue 4, Page 968-980, April 2025.
Infants bear a significant malaria burden but are usually excluded from participating in early dose optimization studies that inform dosing regimens of antimalarial therapy. Unlike older children, infants' exclusion from early‐phase trials has resulted in limited evidence to guide accurate dosing of antimalarial treatment for uncomplicated malaria or ...
Clifford G. Banda, Joel Tarning, Karen I. Barnes   +2 more
wiley   +1 more source

Extending seasonal malaria chemoprevention to five cycles: a pilot study of feasibility and acceptability in Mangodara district, Burkina Faso

BMC Public Health, 2022
Background Seasonal malaria chemoprevention (SMC) involves administering antimalarial drugs at monthly intervals during the high malaria transmission period to children aged 3 to 59 months as recommended by the World Health Organization.
Adama Traore, Laura Donovan, Benoit Sawadogo, Charlotte Ward, Helen Smith, Christian Rassi, Helen Counihan, Johanna Johansson, Sol Richardson, Justin Ragnessi Savadogo, Kevin Baker   +10 more
doaj   +1 more source

Pharmacokinetics of a Novel Piperaquine Dispersible Granules Formulation Under Fasting and Various Fed Conditions Versus Piperaquine Tablets When Fasted in Healthy Tanzanian Adults: A Randomized, Phase I Study

Clinical and Translational Science, Volume 18, Issue 2, February 2025.
ABSTRACT Piperaquine tetraphosphate (PQP), a long‐acting antimalarial, is being considered in a combination for chemoprevention. Dihydroartemisinin‐piperaquine tablets (hard and dispersible) approved for the treatment of acute uncomplicated malaria should be administered in a fasted state, as PQP bioavailability increases with food.
Florence A. Milando, Said Jongo, Salim Abdulla, Gloria Nyaulingo, Anneth‐Mwasi Tumbo, Sarah Mswata, Juliether Tiago, Beatus S. Bongole, Ashura Mirambo, Kamaka Kassimu, Hussein Mbarak, Mohammed A. Rashid, Ali Hamad, Michael Mihayo, Tunu Ndanzi, Omary Zuberi, Naima Saadia, Mariam Somboka, Mariam Yamba‐Yamba, Theresia Ngonyani, Amina Nditi, Margaret Msuya, Bakari Mwalimu, Hajirani M. Msuya, Khamis Awadh, Ali Ali, Anne Claire Marrast, Denis Gossen, Alice Neequaye, Myriam El‐Gaaloul, Hanu Ramachandruni, Isabelle Borghini‐Fuhrer   +31 more
wiley   +1 more source

Population impact of malaria control interventions in the health district of Kati, Mali.

PLoS ONE
BackgroundWHO and its partners have adopted alternative control interventions since the failure to eradicate malaria worldwide in the 1960s and 1970s.
Abdoulaye Katile, Issaka Sagara, Mady Cissoko, Cédric Stéphane Bationo, Mathias Dolo, Pascal Dembélé, Bourama Kamate, Ismaila Simaga, Mahamadou Soumana Sissoko, Jordi Landier, Jean Gaudart   +10 more
doaj   +1 more source

Prioritizing the scale-up of interventions for malaria control and elimination

Malaria Journal, 2019
Background A core set of intervention and treatment options are recommended by the World Health Organization for use against falciparum malaria. These are treatment, long-lasting insecticide-treated bed nets, indoor residual spraying, and chemoprevention
Peter Winskill, Patrick G. Walker, Richard E. Cibulskis, Azra C. Ghani   +3 more
doaj   +1 more source

A LC‐MS/MS Assay for Quantification of Amodiaquine and Desethylamodiaquine in Dried Blood Spots on Filter Paper

International Journal of Analytical Chemistry, Volume 2025, Issue 1, 2025.
Artesunate–amodiaquine (ARS–AQ) is a first‐line antimalarial treatment recommended by the World Health Organization. AQ is the long acting partner drug in this combination, and therapeutic success is correlated with the terminal exposure to AQ. Dried blood spot (DBS) sampling for AQ is a convenient and minimally invasive technique, especially suitable ...
Natpapat Kaewkhao, Joel Tarning, Daniel Blessborn, Daipayan Roy   +3 more
wiley   +1 more source

Making the most of malaria chemoprevention

Malaria Journal
Against a backdrop of stalled progress in malaria control, it is surprising that the various forms of malaria chemoprevention are not more widely used. The World Health Organization (WHO) has recommended several malaria chemoprevention strategies, some ...
Jasper Littmann, Dorothy Achu, Miriam K. Laufer, Corine Karema, David Schellenberg   +4 more
doaj   +1 more source

Determinants of Insecticide‐Treated Net Utilization for Malaria Prevention Among Under‐Five Children in The Gambia: Evidence From National Survey

Journal of Tropical Medicine, Volume 2025, Issue 1, 2025.
Background: Malaria is one of the deadliest mosquito‐borne diseases. Despite the demonstrated benefits of insecticide‐treated nets (ITNs) usage in children under 5 years of age, nonuse is linked to higher mortality and morbidity rates. This study examined how child‐, maternal‐, household‐, and community‐level determinants influence ITN utilization ...
Amadou Barrow, Bakary Kinteh, Mansour Badjie, Amadou Kongira, Ayodeji Matthew Adebayo, Rex A. Kuye, Edrisa Sanyang, Priya Gusain   +7 more
wiley   +1 more source