Results 81 to 90 of about 12,072 (259)

Cost-effectiveness of district-wide seasonal malaria chemoprevention when implemented through routine malaria control programme in Kita, Mali using fixed point distribution [PDF]

, 2021
Background Seasonal malaria chemoprevention (SMC) is a strategy for malaria control recommended by the World Health Organization (WHO) since 2012 for Sahelian countries.
Cairns, Matt, Conteh, Lesong, Diawara, Fatou, Diawara, Halimatou, Dicko, Alassane, Duval, Laeticia, Eckert, Erin, Kamate, Beh, Mihigo, Jules, Sadou, Aboubacar, Sagara, Issaka, Sicuri, Elisa, Steinhardt, Laura C., Walker, Patrick   +13 more
core   +3 more sources

Cardiovascular concentration–effect relationships of amodiaquine and its metabolite desethylamodiaquine: Clinical and preclinical studies

British Journal of Clinical Pharmacology, Volume 89, Issue 3, Page 1176-1186, March 2023., 2023
Aims Amodiaquine is a 4‐aminoquinoline used extensively for the treatment and prevention of malaria. Orally administered amodiaquine is largely converted to the active metabolite desethylamodiaquine. Amodiaquine can cause bradycardia, hypotension, and electrocardiograph QT interval prolongation, but the relationship of these changes to drug ...
Xin Hui S. Chan, Palang Chotsiri, Rebecca A. Capel, James Pike, Borimas Hanboonkunupakarn, Sue J. Lee, Maryam Hanafiah, Yan Naung Win, Maegan A. Cremer, Jean‐René Kiechel, Bernhards Ogutu, Walter R. J. Taylor, Rebecca‐Ann B. Burton, Joel Tarning, Nicholas J. White   +14 more
wiley   +1 more source

Pharmacokinetic considerations in seasonal malaria chemoprevention

Trends in Parasitology, 2022
Los niños africanos menores de 5 años soportan la principal carga de la mortalidad mundial por malaria. La quimioprevención estacional de la malaria (SMC) con sulfadoxina-pirimetamina (SP) más amodiaquina (AQ) administrada mensualmente durante la temporada de lluvias es una intervención altamente efectiva contra la malaria para niños de entre 3 meses y
Chotsiri, P, White, NJ, Tarning, J
openaire   +2 more sources

Clinical and Biological Characteristics of Severe Malaria in Children under 5 Years Old in Benin

Canadian Journal of Infectious Diseases and Medical Microbiology, Volume 2023, Issue 1, 2023., 2023
Background. Malaria is a global public health concern, mainly occurring in sub‐Saharan Africa. Children infected with malaria are more likely to develop severe disease, which can be fatal. During COVID‐19 in 2020, diagnosing and treating malaria became difficult. We analyzed the clinical characteristics and laboratory indicators of children with severe
Xiao Ma, Xin Fan, Kora Chabi Youssaou, Junfei Zhang, Xingyi Wang, Guoqiang Zheng, Shuping Tian, Yujing Gao, Marco Di Luca   +8 more
wiley   +1 more source

Effectiveness of Seasonal Malaria Chemoprevention in children under 10 years of age in Senegal: a stepped-wedge cluster-randomized trial [PDF]

, 2016
This study was done to determine the effectiveness of Seasonal Malaria Chemoprevention in Senegalese children up to 10 years of age using a stepped-wedge design.
Milligan, Paul
core   +2 more sources

7H‐Pyrrolo[2,3‐d]pyrimidine‐4‐amines as Potential Inhibitors of Plasmodium falciparum Calcium‐Dependent Protein Kinases

ChemMedChem, Volume 17, Issue 22, November 18, 2022., 2022
Hitting malaria where it hurts: Pyrrolo[2,3‐d]pyrimidines have been designed as potential inhibitors targeting Plasmodium falciparum calcium‐dependent protein kinase 4 (PfCDPK4) using molecular modelling. Compounds displaying good binding interactions in silico were synthesised and assessed for inhibitory activity against PfCDPK4 and PfCDPK1, with ...
Tswene D. Seanego, Hlamulo E. Chavalala, Hendrik H. Henning, Charles B. de Koning, Heinrich C. Hoppe, Kayode K. Ojo, Amanda L. Rousseau   +6 more
wiley   +1 more source

Near-term climate change impacts on sub-national malaria transmission [PDF]

, 2021
The role of climate change on global malaria is often highlighted in World Health Organisation reports. We modelled a Zambian socio-environmental dataset from 2000 to 2016, against malaria trends and investigated the relationship of near-term ...
Bi, Yaxin, Busiku, Hamainza, Haque, Ubydul, Lubinda, Jailos, Moore, AJ   +4 more
core   +1 more source

Evaluation of direct and indirect effects of seasonal malaria chemoprevention in Mali [PDF]

Scientific Reports, 2018
AbstractRandomized controlled trials have established that seasonal malaria chemoprevention (SMC) in children is a promising strategy to reduce malaria transmission in Sahelian West Africa. This strategy was recently introduced in a dozen countries, and about 12 million children received SMC in 2016. However, evidence on SMC effectiveness under routine
Thomas Druetz, Thomas Druetz
openaire   +3 more sources

A two-strain reaction-diffusion malaria model with seasonality and vector-bias [PDF]

, 2022
To investigate the combined effects of drug resistance, seasonality and vector-bias, we formulate a periodic two-strain reaction-diffusion model. It is a competitive system for resistant and sensitive strains, but the single-strain subsystem is cooperative.
arxiv   +1 more source

Ivermectin as a novel complementary malaria control tool to reduce incidence and prevalence: a modelling study [PDF]

, 2019
BACKGROUND: Ivermectin is a potential new vector control tool to reduce malaria transmission. Mosquitoes feeding on a bloodmeal containing ivermectin have a reduced lifespan, meaning they are less likely to live long enough to complete sporogony and ...
Aljayyoussi, G, Alout, H, Bousema, T, Burrows, J, Chaccour, C, D'Alessandro, U, Foy, BD, Ghani, AC, Hellewell, J, Kobylinski, K, Slater, HC, Smit, MR, Ter Kuile, FO, Walker, PGT, Watson, OJ   +14 more
core   +4 more sources