Results 81 to 90 of about 5,985 (143)

Gametocyte carriage after seasonal malaria chemoprevention in Plasmodium falciparum infected asymptomatic children [PDF]

Malaria Journal, 2020
Abstract Background Treatment of clinical Plasmodium falciparum malaria with sulfadoxine-pyrimethamine (SP) and amodiaquine (AQ) is associated with increased post-treatment gametocyte carriage. The effect of seasonal malaria chemoprevention (SMC) with SP and AQ on gametocyte carriage was assessed in asymptomatic P ...
Abdullahi Ahmad, Abdullahi Ahmad, Mamadou Ousmane Ndiath, John S. Bradley, Jean-Pierre Van Geertruyden, Teun Bousema, Jane Achan, Mamadou Bah, Aurelia Prom, Umberto D'Alessandro, Blessed Etoketim, Chris Drakeley   +11 more
openaire   +8 more sources

Pharmacokinetics of a Novel Piperaquine Dispersible Granules Formulation Under Fasting and Various Fed Conditions Versus Piperaquine Tablets When Fasted in Healthy Tanzanian Adults: A Randomized, Phase I Study

Clinical and Translational Science, Volume 18, Issue 2, February 2025.
ABSTRACT Piperaquine tetraphosphate (PQP), a long‐acting antimalarial, is being considered in a combination for chemoprevention. Dihydroartemisinin‐piperaquine tablets (hard and dispersible) approved for the treatment of acute uncomplicated malaria should be administered in a fasted state, as PQP bioavailability increases with food.
Florence A. Milando, Said Jongo, Salim Abdulla, Gloria Nyaulingo, Anneth‐Mwasi Tumbo, Sarah Mswata, Juliether Tiago, Beatus S. Bongole, Ashura Mirambo, Kamaka Kassimu, Hussein Mbarak, Mohammed A. Rashid, Ali Hamad, Michael Mihayo, Tunu Ndanzi, Omary Zuberi, Naima Saadia, Mariam Somboka, Mariam Yamba‐Yamba, Theresia Ngonyani, Amina Nditi, Margaret Msuya, Bakari Mwalimu, Hajirani M. Msuya, Khamis Awadh, Ali Ali, Anne Claire Marrast, Denis Gossen, Alice Neequaye, Myriam El‐Gaaloul, Hanu Ramachandruni, Isabelle Borghini‐Fuhrer   +31 more
wiley   +1 more source

Optimizing the role of ‘lead mothers’ in seasonal malaria chemoprevention (SMC) campaigns: formative research in Kano State, northern Nigeria

Malaria Journal, 2023
Background Seasonal malaria chemoprevention (SMC) is a safe and effective intervention for preventing malaria in children under 5 years of age. Lead mothers are community health volunteers that help caregivers comply with monthly administration of anti ...
E. Okereke, Helen Smith, Chibuzo Oguoma, Olusola Oresanya, K. Maxwell, Chinedu Anikwe, Lawrence Chijioke Osuji, Obianuju Ogazi, J. Musa, Ashiru Rajab, E. Shekarau, Festus Okoh, Erica Viganò, L. Donovan, Charlotte Ward, K. Baker   +15 more
semanticscholar   +1 more source

A LC‐MS/MS Assay for Quantification of Amodiaquine and Desethylamodiaquine in Dried Blood Spots on Filter Paper

International Journal of Analytical Chemistry, Volume 2025, Issue 1, 2025.
Artesunate–amodiaquine (ARS–AQ) is a first‐line antimalarial treatment recommended by the World Health Organization. AQ is the long acting partner drug in this combination, and therapeutic success is correlated with the terminal exposure to AQ. Dried blood spot (DBS) sampling for AQ is a convenient and minimally invasive technique, especially suitable ...
Natpapat Kaewkhao, Joel Tarning, Daniel Blessborn, Daipayan Roy   +3 more
wiley   +1 more source

Plasmodium falciparum infection status in children less than 10 years old under seasonal malaria chemoprevention and risk of clinical malaria in the Koulikoro health district, Mali

Research Square
Introduction: Seasonal malaria chemoprevention (SMC) with Sulfadoxine pyrimethamine plus amodiaquine (SP + AQ) consist of a monthly administration of therapeutic dose to children under five years of age during the high risk of malaria in area where ...
Daouda Sanogo, Mahamoudou Touré, M. Keita, Fousseyni Kané, S. Keita, I. Sanogo, S. Diawara, Hamady Coulibaly, Sidibé M’Baye Thiam, Mahamadou Diakité, N. Sogoba, Seydou Doumbia   +11 more
semanticscholar   +1 more source

Determinants of Insecticide‐Treated Net Utilization for Malaria Prevention Among Under‐Five Children in The Gambia: Evidence From National Survey

Journal of Tropical Medicine, Volume 2025, Issue 1, 2025.
Background: Malaria is one of the deadliest mosquito‐borne diseases. Despite the demonstrated benefits of insecticide‐treated nets (ITNs) usage in children under 5 years of age, nonuse is linked to higher mortality and morbidity rates. This study examined how child‐, maternal‐, household‐, and community‐level determinants influence ITN utilization ...
Amadou Barrow, Bakary Kinteh, Mansour Badjie, Amadou Kongira, Ayodeji Matthew Adebayo, Rex A. Kuye, Edrisa Sanyang, Priya Gusain   +7 more
wiley   +1 more source

Climate change and resilience of the Senegalese health system in the face of the floods in Keur Massar

The International Journal of Health Planning and Management, Volume 39, Issue 6, Page 1840-1859, November 2024.
Abstract This article is based on the observation that the affected populations perceive existing community‐based adaptation strategies to the health effects of floods differently. We explore the resilience of the local health system to climate change (CC) in Keur Massar (Senegal) using a monographic approach based on a qualitative survey of flooded ...
Abdoulaye Moussa Diallo, Valery Ridde
wiley   +1 more source

Cross‐disciplinary mathematical modelling to benefit healthcare – could clinical pharmacology play an enabling role?

British Journal of Clinical Pharmacology, Volume 90, Issue 10, Page 2509-2516, October 2024.
Abstract Clinical pharmacology is often the nexus in any cross‐disciplinary team that is seeking solutions for human healthcare issues. The use and application of real‐world data and artificial intelligence to better understand our ecosystem has influenced our view at the world and how we do things.
Tirhani Maluleke, Rohan Benecke, Sunday Oladejo, Georg Feulner, Steve Kern, Johanna Lister, Gabriel McClelland, Miriam Njoki, Patrick Noack, Francesco Petruccione, Kanshukan Rajaratnam, Catriona Waitt, Bernd Rosenkranz, Goonaseela Pillai   +13 more
wiley   +1 more source

Seasonal malaria chemoprevention in an area of extended seasonal transmission in Ashanti, Ghana: an individually randomised clinical trial [PDF]

Tropical Medicine & International Health, 2015
AbstractObjectiveTo investigate the effectiveness of seasonal malaria chemoprevention (SMC) and community case management with long‐acting artemisinin‐based combination therapies (ACTs) for the control of malaria in areas of extended seasonal malaria transmission.MethodIndividually randomised, placebo‐controlled trial in the Ashanti Region of Ghana.
Daniel Chandramohan, Princess Ruhama Acheampong, Constance Bart Plange, Harry Tagbor, Gifty Antwi, Matthew Cairns   +5 more
openaire   +4 more sources

Using systems thinking to understand the scale-up and sustainability of health innovation: a case study of seasonal malaria chemoprevention processes in Burkina Faso

BMC Public Health, 2023
Background Scale-up and sustainability are often studied separately, with few studies examining the interdependencies between these two processes and the implementation contexts of innovations towards malaria prevention and control.
M. Niang, Marie-Pierre Gagnon, Sophie Dupéré   +2 more
semanticscholar   +1 more source