Results 81 to 90 of about 3,636 (228)

Seasonal Malaria Chemoprevention in Guinea in 2020: coverage survey results [PDF]

, 2021
In 2020 SMC was implemented in 17 out of 33 prefectures, which include 50% of the population outside the city of Conakry. The COVID-19 pandemic, and the presidential elections in Guinea, could potentially have affected SMC campaigns in 2020, it was therefore important to evaluate coverage of SMC given these challenges and the increased area of ...
Loua, Kovana Marcel, Milligan, Paul
openaire   +2 more sources

Drug resistance mediating Plasmodium falciparum polymorphisms and clinical presentations of parasitaemic children in Uganda. [PDF]

, 2017
BackgroundPlasmodium falciparum genetic polymorphisms that mediate altered drug sensitivity may impact upon virulence. In a cross-sectional study, Ugandan children with infections mutant at pfcrt K76T, pfmdr1 N86Y, or pfmdr1 D1246Y had about one-fourth ...
Arinaitwe, Emmanuel, Conrad, Melissa, Dorsey, Grant, Greenhouse, Bryan, Kamya, Moses R, Nsobya, Samuel L, Rosenthal, Philip J, Tukwasibwe, Stephen, Tumwebaze, Patrick   +8 more
core   +1 more source

Mass campaigns combining antimalarial drugs and anti-infective vaccines as seasonal interventions for malaria control, elimination and prevention of resurgence: a modelling study

BMC Infectious Diseases, 2019
Background The only licensed malaria vaccine, RTS,S/AS01, has been developed for morbidity-control in young children. The potential impact on transmission of deploying such anti-infective vaccines to wider age ranges, possibly with co-administration of ...
Flavia Camponovo, Chris F. Ockenhouse, Cynthia Lee, Melissa A. Penny   +3 more
doaj   +1 more source

A Randomized Trial to Compare the Safety, Tolerability, and Effectiveness of 3 Antimalarial Regimens for the Prevention of Malaria in Nigerian Patients With Sickle Cell Disease. [PDF]

, 2015
BACKGROUND: Malaria prophylaxis is recommended for persons with sickle cell disease (SCD), but the value of this has been questioned. The aim of this study was to find out whether intermittent preventive treatment (IPT) with a fixed-dose combination of ...
Affara, Muna, Bello, Surajudeen, Bojang, Kalifa, Ernest, Kolade, Greenwood, Brian, Ibrahim, Olayinka, Kiechel, Jean-René, Lambe, Tosin, Milligan, Paul, Mokuolu, Olugbenga, Murtala, Rukayat, Nwakanma, Davis, Ogunkunle, Taofik, Ojuawo, Ayotade, Olagunju, Tope, Olaosebikan, Rasaq, Olorunsola, Benedict, Omefe, Peter, Rehman, Andrea M   +18 more
core   +2 more sources

Effect of Seasonal Malaria Chemoprevention on Immune Markers of Exhaustion and Regulation [PDF]

The Journal of Infectious Diseases, 2019
Abstract Background Seasonal malaria chemoprevention (SMC) is a novel strategy to reduce malaria infections in children. Infection with Plasmodium falciparum results in immune dysfunction characterized by elevated expression of markers associated with exhaustion, such as PD1 and LAG3, and regulatory ...
Patrick E. Duffy, Sekouba Keita, Jennifer Kwan, Adama B. Dembele, Oumar Attaher, Almahamoudou Mahamar, Alassane Dicko, Mamoudou B Samassekou, Michal Fried, Barou Coulibaly, Sibiri Sissoko, Moussa B. Kanoute, Bacary S. Diarra, Djibrilla Issiaka, Amadou Barry, Kadidia B. Cisse, Kalifa Diarra, Tiangoua Traore, Irfan Zaidi   +18 more
openaire   +3 more sources

Intermittent preventive treatment with dihydroartemisinin-piperaquine in Ugandan schoolchildren selects for Plasmodium falciparum transporter polymorphisms that modify drug sensitivity. [PDF]

, 2016
Dihydroartemisinin-piperaquine (DP) offers prolonged protection against malaria, but its impact on Plasmodium falciparum drug sensitivity is uncertain. In a trial of intermittent preventive treatment in schoolchildren in Tororo, Uganda, in 2011 to 2012 ...
Brooker, SJ, Conrad, MD, Dorsey, G, Kamya, MR, Legac, J, Nankabirwa, JI, Nsobya, SL, Rosenthal, PJ, Staedke, SG, Tukwasibwe, S, Tumwebaze, P, Wandera, B   +11 more
core   +3 more sources

Sub-national tailoring of seasonal malaria chemoprevention in Mali based on malaria surveillance and rainfall data

Parasites & Vectors, 2022
Abstract Background In malaria endemic countries, seasonal malaria chemoprevention (SMC) interventions are performed during the high malaria transmission in accordance with epidemiological surveillance data. In this study we propose a predictive approach for tailoring the timing and number of cycles of SMC in all health ...
Cissoko, Mady, Sagara, Issaka, Landier, Jordi, Guindo, Abdoulaye, Sanogo, Vincent, Coulibaly, Oumou, Dembélé, Pascal, Dieng, Sokhna, Bationo, Cedric, Diarra, Issa, Magassa, Mahamadou, Berthé, Ibrahima, Katilé, Abdoulaye, Traoré, Diahara, Dessay, Nadine, Gaudart, Jean   +15 more
openaire   +4 more sources

Delivery strategies for malaria vaccination in areas with seasonal malaria transmission

BMJ Global Health, 2023
Background Seasonal vaccination with the RTS,S/AS01E malaria vaccine given alongside seasonal malaria chemoprevention (SMC) substantially reduces malaria in young children.
Jayne Webster, Brian Greenwood, Daniel Chandramohan, Alassane Dicko, Issaka Sagara, Halimatou Diawara, Fatoumata Koita, Seydou Traoré, Jane Grant, Jessica Myers   +9 more
doaj   +1 more source

Independent origin of plasmodium falciparum antifolate super-resistance, Uganda, Tanzania, and Ethiopia. [PDF]

, 2014
Super-resistant Plasmodium falciparum threatens the effectiveness of sulfadoxine-pyrimethamine in intermittent preventive treatment for malaria during pregnancy. It is characterized by the A581G Pfdhps mutation on a background of the double-mutant Pfdhps
Alifrangis, Michael, Cox, Jonathan, Dejene, Seyoum, Ishengoma, Deus, Kavishe, Reginald A, Lemnge, Martha M, Lusingu, John, Lynch, Caroline, Minja, Daniel TR, Nag, Sidsel, Ord, Rosalynn, Pearce, Richard, Pota, Hirva, Roper, Cally, Rwakimari, John, Schousboe, Mette L   +15 more
core   +3 more sources

Implementation strategies for the introduction of the RTS,S/AS01 (RTS,S) malaria vaccine in countries with areas of highly seasonal transmission: workshop meeting report

Malaria Journal, 2023
A workshop on implementation strategies for the introduction of the RTS,S/AS01 (RTS,S) malaria vaccine in countries with areas of highly seasonal transmission, was held as a hybrid meeting in Dakar, Senegal, and online, 23–25 January 2023. Delegates from
Corinne S. Merle, RTSS-SMC working group
doaj   +1 more source