Results 11 to 20 of about 2,867 (139)

Secoisolariciresinol Diglucoside of Flaxseed and Its Metabolites: Biosynthesis and Potential for Nutraceuticals [PDF]

Frontiers in Genetics, 2018
Secoisolariciresinol diglucoside (SDG), found mainly in flaxseed, is one of the essential lignans. SDG, as well as the beneficial fatty acid composition and high fiber content, has made flaxseed an important source of functional food or nutraceutical ...
Parfait Kezimana, Parfait Kezimana, Alexey A. Dmitriev, Anna V. Kudryavtseva, Elena V. Romanova, Nataliya V. Melnikova   +5 more
doaj   +5 more sources

Synthetic Secoisolariciresinol Diglucoside Attenuates Established Pain, Oxidative Stress and Neuroinflammation in a Rodent Model of Painful Radiculopathy [PDF]

Antioxidants, 2020
Painful cervical radiculopathy is characterized by chronic neuroinflammation that lowers endogenous antioxidant responses leading to the development of oxidative stress and pain after neural trauma.
Sonia Kartha, Christine L. Weisshaar, Ralph A. Pietrofesa, Melpo Christofidou-Solomidou, Beth A. Winkelstein   +4 more
doaj   +3 more sources

Secoisolariciresinol diglucoside abrogates oxidative stress-induced damage in cardiac iron overload condition. [PDF]

PLoS ONE, 2015
Cardiac iron overload is directly associated with cardiac dysfunction and can ultimately lead to heart failure. This study examined the effect of secoisolariciresinol diglucoside (SDG), a component of flaxseed, on iron overload induced cardiac damage by ...
Stephanie Puukila, Sean Bryan, Anna Laakso, Jessica Abdel-Malak, Carli Gurney, Adrian Agostino, Adriane Belló-Klein, Kailash Prasad, Neelam Khaper   +8 more
doaj   +4 more sources

Network pharmacology uncovers that secoisolariciresinol diglucoside ameliorate premature ovarian insufficiency via PI3K/Akt pathway [PDF]

Scientific Reports
As one of the essential lignan derivative found in traditional Chinese medicinal herbs, secoisolariciresinol diglucoside (SDG) was proved to promote women’s health through its phytoestrogenic properties.
Yiqing Zhang, Xialu Liu, Zitong Zheng, Haiqiang Huang, Yurou Wang, Shuqin Wu, Yuan Shu, Yuxin Yang, Yufei Zhong, Pengfei Liao, Yongsong Wang, Zezheng Pan   +11 more
doaj   +3 more sources

Secoisolariciresinol diglucoside is a blood-brain barrier protective and anti-inflammatory agent: implications for neuroinflammation [PDF]

Journal of Neuroinflammation, 2018
Background Secoisolariciresinol diglucoside (SDG), the main lignan in flaxseed, is known for its beneficial effects in inflammation, oxidative stress, heart disease, tumor progression, atherosclerosis, and diabetes.
Slava Rom, Viviana Zuluaga-Ramirez, Nancy L. Reichenbach, Michelle A. Erickson, Malika Winfield, Sachin Gajghate, Melpo Christofidou-Solomidou, Kelly L. Jordan-Sciutto, Yuri Persidsky   +8 more
doaj   +3 more sources

Synthetic Lignan Secoisolariciresinol Diglucoside (LGM2605) Reduces Asbestos-Induced Cytotoxicity in an Nrf2-Dependent and -Independent Manner [PDF]

Antioxidants, 2018
Asbestos exposure triggers inflammatory processes associated with oxidative stress and tissue damage linked to malignancy. LGM2605 is the synthetic lignan secoisolariciresinol diglucoside (SDG) with free radical scavenging, antioxidant, and anti ...
Ralph A. Pietrofesa, Shampa Chatterjee, Kyewon Park, Evguenia Arguiri, Steven M. Albelda, Melpo Christofidou-Solomidou   +5 more
doaj   +3 more sources

Protective role of flaxseed lignan secoisolariciresinol diglucoside against lead-acetate-induced oxidative-stress-mediated nephrotoxicity in rats

Phytomedicine Plus, 2021
Background: Lead (Pb) is a toxic heavy metal that causes kidney injury and oxidative tissue damage. Current drugs to treat nephrotoxicity have multiple side-effects. Therefore, the development of novel therapeutic approaches is urgently required. Purpose:
Tareq Aqeel, Sunil Chikkalakshmipura Gurumallu, Ashwini Bhaskar, Saeed Mujahid Hashimi, Nisha Chiriapanda Lohith, Rajesh Javaraiah   +5 more
doaj   +2 more sources

Secoisolariciresinol diglucoside alleviates inflammatory injury in osteoarthritis chondrocytes through ERBB2-associated JAK2/STAT3 signaling: network pharmacology and experimental validation [PDF]

Frontiers in Immunology
BackgroundCartilage injury is a hallmark of osteoarthritis (OA). erb-B2 receptor tyrosine kinase 2 (ERBB2) has been reported to be involved in mediating the therapeutic effects of polyphenols in orthopedic diseases.
Haibei Hu, Gaoshan Li, Yangxu Wang, Suyu Xie, Feng Cao, Huanyu Li, Xubin Gao   +6 more
doaj   +2 more sources

Secoisolariciresinol Diglucoside Alleviates LPS‐Induced Acute Lung Injury by Inhibiting the NF‐κB/NLRP3 Signaling Pathway [PDF]

Drug Development Research, Volume 87, Issue 3, May 2026.
ABSTRACT Acute lung injury (ALI) and its more severe form, acute respiratory distress syndrome (ARDS), are life‐threatening pulmonary disorders with high mortality rates, and effective treatments are currently lacking. Secoisolariciresinol diglucoside (SDG), a plant lignan derived from flaxseed, possesses anti‐inflammatory and antioxidative activities.
Yuanyuan Zhong, Yang Zou, Zhen Qu, Kai Zhou, Huijuan Liu, Jiali Yang, Chengzhong Tang, Yuqiang Xu, Zhen Wang   +8 more
wiley   +2 more sources

Data on mammary gland microRNAs expression, their predicted gene targets and corresponding pathway analysis in female mice receiving flaxseed or its oil and secoisolariciresinol diglucoside components [PDF]

Data in Brief, 2022
Dietary flaxseed may act via microRNAs (miRNAs) to affect the health of the mammary gland. These data are in support of the article entitled “Effects of flaxseed and its components on mammary gland miRNome: identification of potential biomarkers to ...
Diana Wu, Amel Taibi, Zhen Lin, Lilian U. Thompson, Elena M. Comelli   +4 more
doaj   +2 more sources