Results 21 to 30 of about 559 (86)

Biosynthesis of kratom opioids

New Phytologist, Volume 240, Issue 2, Page 757-769, October 2023., 2023
Summary Mitragynine, an analgesic alkaloid from the plant Mitragyna speciosa (kratom), offers a safer alternative to clinical opioids such as morphine, owing to its more favorable side effect profile. Although kratom has been traditionally used for stimulation and pain management in Southeast Asia, the mitragynine biosynthesis pathway has remained ...
Kyunghee Kim, Mohammadamin Shahsavarani, Jorge Jonathan Oswaldo Garza‐García, Jack Edward Carlisle, Jun Guo, Vincenzo De Luca, Yang Qu   +6 more
wiley   +1 more source

Indole Synthesis via Allenyl Ester; Enantioselective Total Synthesis of Geissoschizoline

ChemistryEurope, Volume 3, Issue 5, September 18, 2025.
An indole synthesis via an allenyl ester intermediate at ambient temperature has been developed. The mild reaction conditions allow the use of a broad range of substrates. Notably, the utility of this approach is demonstrated through the asymmetric total synthesis of geissoschizoline, a Strychnos‐type monoterpenoid indole alkaloid.
Sohsuke Moriue, Honami Nishioka, Yuto Fukuda, Hiromitsu Takayama, Mariko Kitajima, Hayato Ishikawa   +5 more
wiley   +1 more source

Integration of cell differentiation and initiation of monoterpenoid indole alkaloid metabolism in seed germination of Catharanthus roseus

New Phytologist, Volume 242, Issue 3, Page 1156-1171, May 2024.
Summary In Catharanthus roseus, monoterpenoid indole alkaloids (MIAs) are produced through the cooperation of four cell types, with final products accumulating in specialized cells known as idioblasts and laticifers. To explore the relationship between cellular differentiation and cell type‐specific MIA metabolism, we analyzed the expression of MIA ...
Mai Uzaki, Tetsuya Mori, Mayuko Sato, Mayumi Wakazaki, Noriko Takeda‐Kamiya, Kotaro Yamamoto, Akio Murakami, Delia Ayled Serna Guerrero, Chizuko Shichijo, Miwa Ohnishi, Kimitsune Ishizaki, Hidehiro Fukaki, Sarah E. O'Connor, Kiminori Toyooka, Tetsuro Mimura, Masami Yokota Hirai   +15 more
wiley   +1 more source

Engineering yeast for sustainable bioproduction of tryptophan-derived aromatic compounds. [PDF]

FEMS Yeast Res
Sun B, Xie X, González A, McCubbin T, Marcellin E, Peng H.   +5 more
europepmc   +1 more source

Directed Biosynthesis of Mitragynine Stereoisomers. [PDF]

J Am Chem Soc, 2023
Schotte C, Jiang Y, Grzech D, Dang TT, Laforest LC, León F, Mottinelli M, Nadakuduti SS, McCurdy CR, O'Connor SE.   +9 more
europepmc   +1 more source

The genome of the medicinal plant Uncaria rhynchophylla provides new insights into monoterpenoid indole alkaloid metabolism and its molecular regulatory mechanism. [PDF]

Mol Hortic
Mu D, Wan L, Shao Y, Pan L, Liu X, Wilson IW, Qing Z, Zhou Y, Lu Y, He Y, Zhu L, Fu J, Wei S, Ma X, Song C, Qiu D, Tang Q.   +16 more
europepmc   +1 more source

A chromosome-level Mitragyna parvifolia genome unveils spirooxindole alkaloid diversification and mitraphylline biosynthesis. [PDF]

Plant Cell
Laforest LC, Nguyen TM, Matsumoto GO, Ramachandria P, Chanderbali A, Kanumuri SRR, Sharma A, McCurdy CR, Dang TT, Nadakuduti SS.   +9 more
europepmc   +1 more source

Profiles of Metabolic Genes in Uncaria rhynchophylla and Characterization of the Critical Enzyme Involved in the Biosynthesis of Bioactive Compounds-(iso)Rhynchophylline. [PDF]

Biomolecules, 2022
Yang M, Yao B, Lin R.
europepmc   +1 more source

Elevated 7-Hydroxymitragynine Levels Found in Products Misbranded as Kratom. [PDF]

J AOAC Int
Brown PN, Chan M, Zhang X, Brendler T.
europepmc   +1 more source

Predicting precursors of plant specialized metabolites using DeepMol automated machine learning. [PDF]

J Integr Bioinform
Capela J, Cheixo J, de Ridder D, Dias O, Rocha M.   +4 more
europepmc   +1 more source