Results 71 to 80 of about 19,188,680 (306)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Recombinant Activated Factor VII as a Second Line Treatment for Postpartum Hemorrhage [PDF]

Korean Journal of Critical Care Medicine, 2017
Background Severe or massive postpartum hemorrhage (PPH) has remained a leading cause of maternal mortality for decades across the world and it results in critical obstetric complications.
Soon Chang Park, Seok Ran Yeom, Sang Kyoon Han, Young Mo Jo, Hyung Bin Kim   +4 more
doaj   +1 more source

Percent of individuals starting partially inactive second-line treatment due to acquired drug resistance during first-line treatment.

, 2012
Percent of individuals starting partially inactive second-line treatment due to acquired drug resistance during first-line treatment.
Valentina Cambiano (146513), Deenan Pillay (7888), Silvia Bertagnolio (57174), Michael R. Jordan (146520), Andrew N. Phillips (146556), Alec Miners (146534), Jens Lundgren (146550), Viktor von Wyl (146506)   +7 more
core   +1 more source

Clinical potential of nintedanib for the second-line treatment of advanced non-small-cell lung cancer: current evidence [PDF]

, 2014
Sacha I Rothschild Department of Internal Medicine, Medical Oncology, University Hospital Basel, Basel, Switzerland Abstract: The therapeutic landscape in non-small-cell lung cancer (NSCLC) is changing.
Rothschild SI
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Nitroimidazole - albendazole combination therapy, quinacrine use, and risk factors in nitroimidazole-refractory giardiasis: a prospective multicentre observational study

BMC Infectious Diseases
Background Nitroimidazole-refractory giardiasis is an increasing problem. We present data on efficacy of a treatment ladder and on clinical characteristics and assemblage types in nitroimidazole-refractory giardiasis.
Kristine Mørch, Peter Chiodini, Laura Nabarro, Raisa Hannula, Andreas Neumayr, Christel Gill Haanshuus, Christina Saghaug, Bjørn Blomberg, Frank Olav Dahler Pettersen, Helene Heitmann Sandnes, Kurt Hanevik, Nina Langeland   +11 more
doaj   +1 more source

Second-line treatment initiation within 6 mo, time to treatment, and site of treatment initiation by age, sex, HIV status, diagnostic facility, and diagnostic test (new rifampicin-resistant tuberculosis patients, 2013 cohort).

, 2017
Second-line treatment initiation within 6 mo, time to treatment, and site of treatment initiation by age, sex, HIV status, diagnostic facility, and diagnostic test (new rifampicin-resistant tuberculosis patients, 2013 cohort).
Norbert Ndjeka (3768898), Anja van’t Hoog (300467), Helen Cox (66086), Lindy Dickson-Hall (3768895), Alison Grant (790918), Frank Cobelens (109566), Mark Nicol (3498533), Wendy Stevens (62288)   +7 more
core   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Second-line systemic treatment for advanced cholangiocarcinoma.

, 2014
371 Background: Five-year survival for advanced cholangiocarcinoma (aCC) is reported at 5-10%. For advanced, unresectable patients, gemcitabine plus platinum (GEM-P) combination chemotherapy is common practice as first-line treatment with progression ...
Ahmed Omar Kaseb, Rachna T. Shroff, Lindsey Law, D. Van Nguyen, Jane Elizabeth Rogers, Wei Qiao, Milind M. Javle   +6 more
core   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source