Results 81 to 90 of about 19,188,680 (306)

Systemic treatment in EGFR-ALK NSCLC patients: second line therapy and beyond

Cancer Biology & Medicine, 2014
Lung cancer is the most frequently diagnosed cancer and a leading cause of cancer mortality worldwide, with adenocarcinoma being the most common histological subtype.
Niki Karachaliou, Rafael Rosell
doaj   +1 more source

Quality of Life in Second-Line Treatment of Metastatic Castration-Resistant Prostate Cancer Using Cabazitaxel or Other Therapies After Previous Docetaxel Chemotherapy: Swiss Observational Treatment Registry. [PDF]

, 2017
BACKGROUND The aim was to evaluate quality of life (QoL), pain, and fatigue in patients with metastatic castration-resistant prostate cancer (mCRPC) treated with different regimens after first-line docetaxel, as well as disease progression ...
Frank Stenner, Rudolf Morant, Caspar, Clemens, Clemens Caspar, Urs Huber, Reinhard Zenhäusern, Richard Cathomas, Rauch, Daniel, Cathomas, Richard, Morant, Rudolf, Daniel Rauch, Rentsch, Cyrill, Razvan Popescu, Cyrill Rentsch, Betticher, Daniel, Sacha I. Rothschild, Daniel Betticher, Rothschild, Sacha I, Zenhäusern, Reinhard, Popescu, Razvan, Huber, Urs, Stenner, Frank, Rothschild SI, Zenhäusern R, Morant R, Huber U, Stenner F, Popescu R, Betticher D, Rentsch C, Rauch D, Caspar C, Cathomas R   +32 more
core   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Characteristics of the 687 patients at the time of switch to second-line treatment.

, 2021
Characteristics of the 687 patients at the time of switch to second-line treatment.
Theonestina Byakuzana (11840844), Fiona Vanobberghen (2735740), Tracy Renée Glass (9384553), Daniel Henry Paris (8087936), Fabian Franzeck (11840835), Manuel Battegay (88668), Elizabeth Senkoro (11840841), Herry Mapesi (4255984), James Okuma (703631), Robert Ndege (5009420), Maja Weisser (659648), Herieth Ismael Wilson (11840838)   +11 more
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

HIV drug resistance, early treatment outcomes and impact of guidelines compliance after protease inhibitor‐based second‐line failure in a dedicated resistance clinic in western Kenya: a retrospective cohort study

Journal of the International AIDS Society
Introduction Data on drug resistance, viral outcomes and guidelines compliance following protease inhibitor (PI)‐based second‐line failure in low‐ and middle‐income countries are limited, particularly in the era of dolutegravir‐containing antiretroviral ...
John M. Humphrey, Shamim M. Ali, Allison DeLong, Vlad Novitsky, Edwin Sang, Bilal Jawed, Emmanuel Kemboi, Celia Ngetich, Suzanne Goodrich, Adrian Gardner, Joseph W. Hogan, Rami Kantor   +11 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Clinical use of alprostadil topical cream in patients with erectile dysfunction: a review

Research and Reports in Urology, 2016
James Anaissie, Wayne JG Hellstrom Department of Urology, Tulane University School of Medicine, New Orleans, LA, USA Abstract: Erectile dysfunction (ED) is a common and debilitating disorder seen in over 50% of men older than 70 years.
Anaissie J, Hellstrom WJG
doaj  

MDR-TB treatment outcomes by previous treatment with second-line drugs

, 2013
MDR-TB treatment outcomes by previous treatment with second-line ...
Sholpan Allamuratova (66088), Helen S. Cox (80991), Yared Kebede (66087), Stobdan Kalon (80992), Hamraev A. Karimovich (80995), Vinciane Sizaire (80993), Zinaida N. Tigay (80994), Sabine Rüsch-Gerdes (62811), Clair Mills (75046)   +8 more
core   +1 more source