Results 71 to 80 of about 360,391 (324)

A Scalable Model of Cerebellar Adaptive Timing and Sequencing: The Recurrent Slide and Latch (RSL) Model [PDF]

, 2000
From the dawn of modern neural network theory, the mammalian cerebellum has been a favored object of mathematical modeling studies. Early studies focused on the fan-out, convergence, thresholding, and learned weighting of perceptual-motor signals within ...
Bullock, Daniel, Rhodes, Bradley
core   +1 more source

Bimetallic Nanoreactor Activates cGAS‐STING Pathway via mtDNA Release for Cancer Metalloimmunotherapy

Advanced Functional Materials, EarlyView.
A bimetallic Mn–Ca nanoreactor (MCC) is developed as a non‐nucleotide STING nanoagonist for cancer metalloimmunotherapy. MCC induces Ca2+ overload and hydroxyl radical generation, resulting in mitochondrial damage and mtDNA release. The released mtDNA cooperates with Mn2+ to robustly activate cGAS–STING signaling.
Xin Wang Mo, Nguyen Thi Nguyen, LiLi Guo, Ngoc Man Phan, Hyunsu Shin, Tae‐il Kim, Yu Seok Youn, Jaeyun Kim   +7 more
wiley   +1 more source

Modeling Human Ad Hoc Coordination

, 2016
Whether in groups of humans or groups of computer agents, collaboration is most effective between individuals who have the ability to coordinate on a joint strategy for collective action.
Baker, Chris L., Krafft, Peter M., Pentland, Alex, Tenenbaum, Joshua B.   +3 more
core   +1 more source

Origin of symbol-using systems: speech, but not sign, without the semantic urge [PDF]

, 2014
Natural language—spoken and signed—is a multichannel phenomenon, involving facial and body expression, and voice and visual intonation that is often used in the service of a social urge to communicate meaning.
Alberts B, Baldwin JM, Darwin C, Darwin C, Deacon TW, Donald M, Fauconnier G, Gross CG, Hauser M, Jablonski NG, Jackendoff R, Judson HF, Kendon A, King BJ, Klima ES, Knight C, Langacker R, Martin I. Sereno, Merker B, Miller SL, Mithen S, Rubens AB, Sereno MI, Sereno MI, Sereno ML, Wills C, Woese CR, Yip M   +27 more
core   +2 more sources

High‐Resolution Characterization of Protein‐Conjugated, mRNA‐Loaded Lipid Nanoparticles by Analytical Ultracentrifugation

Advanced Functional Materials, EarlyView.
Lipid nanoparticles containing messenger RNA are characterized by sedimentation velocity analytical ultracentrifugation using UltraScan's new Custom Grid algorithm to provide multi‐dimensional distributions for partial specific volume (particle density), molar mass, sedimentation, diffusion, and hydrodynamic radius.
Sophia Bird, Connor Smith, Nahal Habibi, Samantha Rivera, Saeed Mortezazadeh, Reece Martin, Benjamin M. Geilich, Gilles Besin, Borries Demeler   +8 more
wiley   +1 more source

Seamless mobility with personal servers [PDF]

, 2003
We describe the concept and the taxonomy of personal servers, and their implications in seamless mobility. Personal servers could offer electronic services independently of network availability or quality, provide a greater flexibility in the choice of ...
Bylund, Markus, Segall, Zary
core   +1 more source

Type III CRISPR–Cas systems produce cyclic oligoadenylate second messengers [PDF]

Nature, 2017
In many prokaryotes, type III clustered regularly interspaced short palindromic repeat (CRISPR)-CRISPR-associated (Cas) systems detect and degrade invasive genetic elements by an RNA-guided, RNA-targeting multisubunit interference complex. The CRISPR-associated protein Csm6 additionally contributes to interference by functioning as a standalone RNase ...
Niewoehner, Ole, Garcia-Doval, Carmela, Rostøl, Jakob T, Berk, Christian, Schwede, Frank, Bigler, Laurent, Hall, Jonathan, Marraffini, Luciano A, Jinek, Martin   +8 more
openaire   +2 more sources

Enhancing Synaptic Plasticity and Multistate Retention of Organic Neuromorphic Devices Using Anion‐Excessive Gel Electrolyte

Advanced Functional Materials, EarlyView.
Anion‐excessive gel‐based organic synaptic transistors (AEG‐OSTs) that can maintain electrical neutrality are developed to enhance synaptic plasticity and multistate retention. Key improvement is attributed to the maintenance of electrical neutrality in the electrolyte even after electrochemical doping, which reduces the Coulombic force acting on ...
Yousang Won, Jeongwoo Lee, Hyunwook Kim, Joon Hak Oh   +3 more
wiley   +1 more source

Magnetic dipole moment of neutral particles from quantum corrections at two-loop order

, 2013
The tentative gamma-ray line in the Fermi data at ~135 GeV motivates a dark matter candidate that couples to photons through loops of charged messengers.
Tamarit, Carlos, Yavin, Itay
core   +1 more source

Event-based simulation of quantum physics experiments [PDF]

, 2014
We review an event-based simulation approach which reproduces the statistical distributions of wave theory not by requiring the knowledge of the solution of the wave equation of the whole system but by generating detection events one-by-one according to ...
De Raedt, Hans, Michielsen, Kristel
core   +1 more source